DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17760 and GPA1

DIOPT Version :9

Sequence 1:	NP_001036539.1	Gene:	CG17760 / 36385	FlyBaseID:	FBgn0033756	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_011868.1	Gene:	GPA1 / 856394	SGDID:	S000001047	Length:	472	Species:	Saccharomyces cerevisiae

Alignment Length:	477	Identity:	145/477 - (30%)
Similarity:	226/477 - (47%)	Gaps:	129/477 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDCCLSDQA--------CEERRISREIDKFLKAEKKKARRELKLLVLGTGESGKTTFIKQMRIIH 57
            |.|.:|.|.        .:.:|.:..|::.|:.||::.:.|:|||:||.|||||:|.:||::::|
Yeast     1 MGCTVSTQTIGDESDPFLQNKRANDVIEQSLQLEKQRDKNEIKLLLLGAGESGKSTVLKQLKLLH 65

  Fly    58 GKGFLDKERKQFTKNVFQNIFMAIQSM----------------------------------ISAM 88
            ..||..:||.|:.:.::.:   |||||                                  ..|:
Yeast    66 QGGFSHQERLQYAQVIWAD---AIQSMKILIIQARKLGIQLDCDDPINNKDLFACKRILLKAKAL 127

  Fly    89 DTLR--------------IPYGQQ------------------EHSKLADLVKS---IDYKTVTRL 118
            |.:.              :.|.::                  |...::: |||   .|.:|||:.
Yeast   128 DYINASVAGGSDFLNDYVLKYSERYETRRRVQSTGRAKAAFDEDGNISN-VKSDTDRDAETVTQN 191

  Fly   119 EAPYLN----------------------------------------------AIKTLW-KDAGIK 136
            |....|                                              |||.|| .|.|||
Yeast   192 EDADRNNSSRINLQDICKDLNQEGDDQMFVRKTSREIQGQNRRNLIHEDIAKAIKQLWNNDKGIK 256

  Fly   137 ECYNRRREYQLTDSTEYFLNDIARIERSDYQATDQDILHVRAPTTNIVEYPFNLDGFLIRLVDVA 201
            :|:.|..|:||..|..|:.::|.:....:|..||:|||..|..||.|.|..||:.....:::|..
Yeast   257 QCFARSNEFQLEGSAAYYFDNIEKFASPNYVCTDEDILKGRIKTTGITETEFNIGSSKFKVLDAG 321

  Fly   202 GQRTERRKWIHCFSNVTSIMFLVAMSEFDLSLAESENDNRMKESKALFHNIISFSWFQHSSVILF 266
            |||:||:||||||..:|:::|::||||:|..|.|.|..|||.||..||..:::..||:.:..|||
Yeast   322 GQRSERKKWIHCFEGITAVLFVLAMSEYDQMLFEDERVNRMHESIMLFDTLLNSKWFKDTPFILF 386

  Fly   267 LNKEDLFKKKILSTHLADYFPEYNGPKKDAKAAREFILYMFTSVNPDPYKCIYPHFTVATNTENI 331
            |||.|||::|:.|..:..|||:|.|...||:|..::...:|.|:| ...|.||...|.||:|:.:
Yeast   387 LNKIDLFEEKVKSMPIRKYFPDYQGRVGDAEAGLKYFEKIFLSLN-KTNKPIYVKRTCATDTQTM 450

  Fly   332 KFVFTAVKDTILELHLSETNLL 353
            |||.:||.|.|::.:|.:..::
Yeast   451 KFVLSAVTDLIIQQNLKKIGII 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17760	NP_001036539.1	G_alpha	13..351	CDD:214595	141/453 (31%)
CG17760	NP_001036539.1	G-alpha	34..347	CDD:206639	134/428 (31%)
GPA1	NP_011868.1	G-alpha	42..466	CDD:206639	134/428 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
TreeFam	0	0.000	Not matched by this tool.
	6	5.750