DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17760 and Gna11

DIOPT Version :9

Sequence 1:	NP_001036539.1	Gene:	CG17760 / 36385	FlyBaseID:	FBgn0033756	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_112295.1	Gene:	Gna11 / 81662	RGDID:	619749	Length:	359	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	218/351 - (62%)
Similarity:	283/351 - (80%)	Gaps:	0/351 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CCLSDQACEERRISREIDKFLKAEKKKARRELKLLVLGTGESGKTTFIKQMRIIHGKGFLDKERK 67
            |||||:..|.:||:.||:|.|:.:|:.||||||||:||||||||:|||||||||||.|:.:::::
  Rat     9 CCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKR 73

  Fly    68 QFTKNVFQNIFMAIQSMISAMDTLRIPYGQQEHSKLADLVKSIDYKTVTRLEAPYLNAIKTLWKD 132
            .|||.|:||||.|:|:::.|||||:|.|..:::...|.|::.:|.:.||..|..|:|||||||.|
  Rat    74 GFTKLVYQNIFTAMQAVVRAMDTLKIRYKYEQNKANALLIREVDVEKVTTFEHQYVNAIKTLWSD 138

  Fly   133 AGIKECYNRRREYQLTDSTEYFLNDIARIERSDYQATDQDILHVRAPTTNIVEYPFNLDGFLIRL 197
            .|::|||:||||:||:||.:|:|.|:.||....|..|.||:|.||.|||.|:||||:|:..:.|:
  Rat   139 PGVQECYDRRREFQLSDSAKYYLTDVDRIATVGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRM 203

  Fly   198 VDVAGQRTERRKWIHCFSNVTSIMFLVAMSEFDLSLAESENDNRMKESKALFHNIISFSWFQHSS 262
            |||.|||:|||||||||.||||||||||:||:|..|.||:|:|||:||||||..||::.||||||
  Rat   204 VDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQHSS 268

  Fly   263 VILFLNKEDLFKKKILSTHLADYFPEYNGPKKDAKAAREFILYMFTSVNPDPYKCIYPHFTVATN 327
            |||||||:||.:.|||.:||.|||||::||::||:|||||||.||..:|||..|.||.|||.||:
  Rat   269 VILFLNKKDLLEDKILHSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATD 333

  Fly   328 TENIKFVFTAVKDTILELHLSETNLL 353
            ||||:|||.|||||||:|:|.|.||:
  Rat   334 TENIRFVFAAVKDTILQLNLKEYNLV 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17760	NP_001036539.1	G_alpha	13..351	CDD:214595	210/337 (62%)
CG17760	NP_001036539.1	G-alpha	34..347	CDD:206639	197/312 (63%)
Gna11	NP_112295.1	G_alpha	19..357	CDD:214595	210/337 (62%)
		G-alpha	40..353	CDD:206639	197/312 (63%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	41..54		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	178..186		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	201..210		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	329..334		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D373878at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.720