DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17760 and GNAZ

DIOPT Version :9

Sequence 1:	NP_001036539.1	Gene:	CG17760 / 36385	FlyBaseID:	FBgn0033756	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_002064.1	Gene:	GNAZ / 2781	HGNCID:	4395	Length:	355	Species:	Homo sapiens

Alignment Length:	363	Identity:	147/363 - (40%)
Similarity:	207/363 - (57%)	Gaps:	20/363 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDCCLSDQACEERRISREIDKFLKAEKKKARRELKLLVLGTGESGKTTFIKQMRIIHGKGFLDKE 65
            |.|..|.:..|..|.||.||:.|::|.::.|||:|||:|||..|||:|.:|||:|||..||..:.
Human     1 MGCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNSGKSTIVKQMKIIHSGGFNLEA 65

  Fly    66 RKQFTKNVFQNIFMAIQSMISAMDTLRIPYGQQEHSKLADLVKSIDYKTVTRLEAP--------- 121
            .|::...:..|...::..:|.|:..|||.:...:        ::.|...:..|..|
Human    66 CKEYKPLIIYNAIDSLTRIIRALAALRIDFHNPD--------RAYDAVQLFALTGPAESKGEITP 122

  Fly   122 -YLNAIKTLWKDAGIKECYNRRREYQLTDSTEYFLNDIARIERSDYQATDQDILHVRAPTTNIVE 185
             .|..::.||.|.|.:.|::|..||.|.|:..|:|||:.||..:||..|.:|||..|..||.|||
Human   123 ELLGVMRRLWADPGAQACFSRSSEYHLEDNAAYYLNDLERIAAADYIPTVEDILRSRDMTTGIVE 187

  Fly   186 YPFNLDGFLIRLVDVAGQRTERRKWIHCFSNVTSIMFLVAMSEFDLSLAESENDNRMKESKALFH 250
            ..|.......::|||.|||:||:||||||..||:|:|.|.:|.:||.|.|....:||.||..||.
Human   188 NKFTFKELTFKMVDVGGQRSERKKWIHCFEGVTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFD 252

  Fly   251 NIISFSWFQHSSVILFLNKEDLFKKKILSTHLADYFPEYNGPKKDAKAAREFILYMFTSVNPD-P 314
            :|.:.:||.::|:||||||:||..:||....|...||||.|.....:|| .:|...|..:|.: .
Human   253 SICNNNWFINTSLILFLNKKDLLAEKIRRIPLTICFPEYKGQNTYEEAA-VYIQRQFEDLNRNKE 316

  Fly   315 YKCIYPHFTVATNTENIKFVFTAVKDTILELHLSETNL 352
            .|.||.|||.||:|.||:|||.||.|.|::.:|....|
Human   317 TKEIYSHFTCATDTSNIQFVFDAVTDVIIQNNLKYIGL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17760	NP_001036539.1	G_alpha	13..351	CDD:214595	142/348 (41%)
CG17760	NP_001036539.1	G-alpha	34..347	CDD:206639	131/323 (41%)
GNAZ	NP_002064.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		10/24 (42%)
		G-alpha	34..349	CDD:206639	131/323 (41%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		9/12 (75%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		4/8 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760