DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17760 and GNAT2

DIOPT Version :9

Sequence 1:	NP_001036539.1	Gene:	CG17760 / 36385	FlyBaseID:	FBgn0033756	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_001364224.1	Gene:	GNAT2 / 2780	HGNCID:	4394	Length:	354	Species:	Homo sapiens

Alignment Length:	355	Identity:	143/355 - (40%)
Similarity:	216/355 - (60%)	Gaps:	12/355 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SDQACEERRI---SREIDKFLKAEKKKARRELKLLVLGTGESGKTTFIKQMRIIHGKGFLDKERK 67
            |..:.|::.:   |:|::|.|:.:..|..:.:|||:||.|||||:|.:|||:|||..|:..:|..
Human     3 SGASAEDKELAKRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDGYSPEECL 67

  Fly    68 QFTKNVFQNIFMAIQSMISAMDTLRIPYGQ----QEHSKLADLVKSIDYKTVTRLEAPYLNAIKT 128
            :|...::.|:..:|.::|.||.||.|.|.:    .:..:|.:|..||:..|   :....:..|:.
Human    68 EFKAIIYGNVLQSILAIIRAMTTLGIDYAEPSCADDGRQLNNLADSIEEGT---MPPELVEVIRR 129

  Fly   129 LWKDAGIKECYNRRREYQLTDSTEYFLNDIARIERSDYQATDQDILHVRAPTTNIVEYPFNLDGF 193
            ||||.|::.|:.|..||||.||..|:||.:.||...:|..::||:|..|..||.|:|..|::...
Human   130 LWKDGGVQACFERAAEYQLNDSASYYLNQLERITDPEYLPSEQDVLRSRVKTTGIIETKFSVKDL 194

  Fly   194 LIRLVDVAGQRTERRKWIHCFSNVTSIMFLVAMSEFDLSLAESENDNRMKESKALFHNIISFSWF 258
            ..|:.||.|||:||:||||||..||.|:|..|:|.:|:.|.|.:..|||.||..||::|.:..:|
Human   195 NFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKFF 259

  Fly   259 QHSSVILFLNKEDLFKKKILSTHLADYFPEYNGPKKDAKAAREFILYMFTSVN-PDPYKCIYPHF 322
            ..:|::|||||:|||::||...||:..||||:| ......|..:|...|..:| ....|.||.|.
Human   260 AATSIVLFLNKKDLFEEKIKKVHLSICFPEYDG-NNSYDDAGNYIKSQFLDLNMRKDVKEIYSHM 323

  Fly   323 TVATNTENIKFVFTAVKDTILELHLSETNL 352
            |.||:|:|:||||.||.|.|::.:|.:..|
Human   324 TCATDTQNVKFVFDAVTDIIIKENLKDCGL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17760	NP_001036539.1	G_alpha	13..351	CDD:214595	140/345 (41%)
CG17760	NP_001036539.1	G-alpha	34..347	CDD:206639	134/317 (42%)
GNAT2	NP_001364224.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		6/23 (26%)
		G-alpha	34..348	CDD:206639	134/317 (42%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		4/8 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830