DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17760 and GNAO1

DIOPT Version :9

Sequence 1:	NP_001036539.1	Gene:	CG17760 / 36385	FlyBaseID:	FBgn0033756	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_066268.1	Gene:	GNAO1 / 2775	HGNCID:	4389	Length:	354	Species:	Homo sapiens

Alignment Length:	357	Identity:	167/357 - (46%)
Similarity:	225/357 - (63%)	Gaps:	19/357 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDCCLS--DQACEERRISREIDKFLKAEKKKARRELKLLVLGTGESGKTTFIKQMRIIHGKGFLD 63
            |.|.||  ::|..||  |:.|:|.||.:...|.:::|||:||.|||||:|.:|||:|||..||..
Human     1 MGCTLSAEERAALER--SKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSG 63

  Fly    64 KERKQFTKNVFQNIFMAIQSMISAMDTLRIPYGQQEHSKLADLVKSIDYKTVTRLE------APY 122
            ::.||:...|:.|...::.:::.|||||.|.||.:|....|.:|..:    |:|:|      |..
Human    64 EDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDV----VSRMEDTEPFSAEL 124

  Fly   123 LNAIKTLWKDAGIKECYNRRREYQLTDSTEYFLNDIARIERSDYQATDQDILHVRAPTTNIVEYP 187
            |:|:..||.|:||:||:||.|||||.||.:|:|:.:.||..:|||.|:||||..|..||.|||..
Human   125 LSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETH 189

  Fly   188 FNLDGFLIRLVDVAGQRTERRKWIHCFSNVTSIMFLVAMSEFDLSLAESENDNRMKESKALFHNI 252
            |.......||.||.|||:||:||||||.:||:|:|.||:|.:|..|.|.|..|||.||..||.:|
Human   190 FTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSI 254

  Fly   253 ISFSWFQHSSVILFLNKEDLFKKKILSTHLADYFPEYNGPK--KDAKAAREFILYMFTSVNPDPY 315
            .:..:|..:|:||||||:|||.:||..:.|...||||.||.  :||.|   :|...|.|.|..|.
Human   255 CNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAA---YIQAQFESKNRSPN 316

  Fly   316 KCIYPHFTVATNTENIKFVFTAVKDTILELHL 347
            |.||.|.|.||:|.||:.||.||.|.|:..:|
Human   317 KEIYCHMTCATDTNNIQVVFDAVTDIIIANNL 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17760	NP_001036539.1	G_alpha	13..351	CDD:214595	161/343 (47%)
CG17760	NP_001036539.1	G-alpha	34..347	CDD:206639	153/320 (48%)
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	153/320 (48%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830