DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17760 and GNAI2

DIOPT Version :9

Sequence 1:	NP_001036539.1	Gene:	CG17760 / 36385	FlyBaseID:	FBgn0033756	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_002061.1	Gene:	GNAI2 / 2771	HGNCID:	4385	Length:	355	Species:	Homo sapiens

Alignment Length:	360	Identity:	161/360 - (44%)
Similarity:	222/360 - (61%)	Gaps:	14/360 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDCCLS--DQACEERRISREIDKFLKAEKKKARRELKLLVLGTGESGKTTFIKQMRIIHGKGFLD 63
            |.|.:|  |:|..||  |:.|||.|:.:.:||.||:|||:||.|||||:|.:|||:|||..|:.:
Human     1 MGCTVSAEDKAAAER--SKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSE 63

  Fly    64 KERKQFTKNVFQNIFMAIQSMISAMDTLRIPYGQQEHSKLADLVKSIDYKTVTRLEAPYL----- 123
            :|.:|:...|:.|...:|.:::.||..|:|.:.....   ||..:.:...:.|..|...|
Human    64 EECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSR---ADDARQLFALSCTAEEQGVLPDDLS 125

  Fly   124 NAIKTLWKDAGIKECYNRRREYQLTDSTEYFLNDIARIERSDYQATDQDILHVRAPTTNIVEYPF 188
            ..|:.||.|.|::.|:.|.|||||.||..|:|||:.||.:|||..|.||:|..|..||.|||..|
Human   126 GVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHF 190

  Fly   189 NLDGFLIRLVDVAGQRTERRKWIHCFSNVTSIMFLVAMSEFDLSLAESENDNRMKESKALFHNII 253
            .......::.||.|||:||:||||||..||:|:|.||:|.:||.|||.|..|||.||..||.:|.
Human   191 TFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSIC 255

  Fly   254 SFSWFQHSSVILFLNKEDLFKKKILSTHLADYFPEYNGPKKDAKAAREFILYMFTSVNP-DPYKC 317
            :..||..:|:||||||:|||::||..:.|...||||.|..|..:|| .:|...|..:|. ...|.
Human   256 NNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAA-SYIQSKFEDLNKRKDTKE 319

  Fly   318 IYPHFTVATNTENIKFVFTAVKDTILELHLSETNL 352
            ||.|||.||:|:|::|||.||.|.|::.:|.:..|
Human   320 IYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17760	NP_001036539.1	G_alpha	13..351	CDD:214595	154/343 (45%)
CG17760	NP_001036539.1	G-alpha	34..347	CDD:206639	143/318 (45%)
GNAI2	NP_002061.1	G-alpha	34..349	CDD:206639	143/318 (45%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		3/8 (38%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830