DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17760 and Gnai1

DIOPT Version :9

Sequence 1:	NP_001036539.1	Gene:	CG17760 / 36385	FlyBaseID:	FBgn0033756	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_037277.1	Gene:	Gnai1 / 25686	RGDID:	2713	Length:	354	Species:	Rattus norvegicus

Alignment Length:	364	Identity:	163/364 - (44%)
Similarity:	228/364 - (62%)	Gaps:	23/364 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDCCLS--DQACEERRISREIDKFLKAEKKKARRELKLLVLGTGESGKTTFIKQMRIIHGKGFLD 63
            |.|.||  |:|..||  |:.||:.|:.:.:||.||:|||:||.|||||:|.:|||:|||..|:.:
  Rat     1 MGCTLSAEDKAAVER--SKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSE 63

  Fly    64 KERKQFTKNVFQNIFMAIQSMISAMDTLRIPYGQQEHSKLADLVKSIDYKTVTRL----EAPYLN 124
            :|.||:...|:.|...:|.::|.||..|:|.:|        |..::.|.:.:..|    |..::.
  Rat    64 EECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFG--------DAARADDARQLFVLAGAAEEGFMT 120

  Fly   125 A-----IKTLWKDAGIKECYNRRREYQLTDSTEYFLNDIARIERSDYQATDQDILHVRAPTTNIV 184
            |     ||.||||:|::.|:||.|||||.||..|:|||:.||.:.:|..|.||:|..|..||.||
  Rat   121 AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIV 185

  Fly   185 EYPFNLDGFLIRLVDVAGQRTERRKWIHCFSNVTSIMFLVAMSEFDLSLAESENDNRMKESKALF 249
            |..|.......::.||.|||:||:||||||..||:|:|.||:|::||.|||.|..|||.||..||
  Rat   186 ETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLF 250

  Fly   250 HNIISFSWFQHSSVILFLNKEDLFKKKILSTHLADYFPEYNGPKKDAKAAREFILYMFTSVNP-D 313
            .:|.:..||..:|:||||||:|||::||..:.|...:|||.|.....:|| .:|...|..:|. .
  Rat   251 DSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA-AYIQCQFEDLNKRK 314

  Fly   314 PYKCIYPHFTVATNTENIKFVFTAVKDTILELHLSETNL 352
            ..|.||.|||.||:|:|::|||.||.|.|::.:|.:..|
  Rat   315 DTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17760	NP_001036539.1	G_alpha	13..351	CDD:214595	155/347 (45%)
CG17760	NP_001036539.1	G-alpha	34..347	CDD:206639	145/322 (45%)
Gnai1	NP_037277.1	G-alpha	34..348	CDD:206639	145/322 (45%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		3/8 (38%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930