DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17760 and Gnaq

DIOPT Version :9

Sequence 1:	NP_001036539.1	Gene:	CG17760 / 36385	FlyBaseID:	FBgn0033756	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_032165.3	Gene:	Gnaq / 14682	MGIID:	95776	Length:	359	Species:	Mus musculus

Alignment Length:	354	Identity:	227/354 - (64%)
Similarity:	291/354 - (82%)	Gaps:	2/354 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDCCLSDQACEERRISREIDKFLKAEKKKARRELKLLVLGTGESGKTTFIKQMRIIHGKGFLDKE 65
            |.||||::|.|.|||:.||::.|:.:|:.||||||||:||||||||:|||||||||||.|:.|::
Mouse     7 MACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 71

  Fly    66 RKQFTKNVFQNIFMAIQSMISAMDTLRIPYGQQEHSKL-ADLVKSIDYKTVTRLEAPYLNAIKTL 129
            ::.|||.|:||||.|:|:||.|||||:||| :.||:|. |.||:.:|.:.|:..|.||::|||:|
Mouse    72 KRGFTKLVYQNIFTAMQAMIRAMDTLKIPY-KYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSL 135

  Fly   130 WKDAGIKECYNRRREYQLTDSTEYFLNDIARIERSDYQATDQDILHVRAPTTNIVEYPFNLDGFL 194
            |.|.||:|||:|||||||:|||:|:|||:.|:....|..|.||:|.||.|||.|:||||:|...:
Mouse   136 WNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDLQSVI 200

  Fly   195 IRLVDVAGQRTERRKWIHCFSNVTSIMFLVAMSEFDLSLAESENDNRMKESKALFHNIISFSWFQ 259
            .|:|||.|||:|||||||||.||||||||||:||:|..|.||:|:|||:||||||..||::.|||
Mouse   201 FRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQ 265

  Fly   260 HSSVILFLNKEDLFKKKILSTHLADYFPEYNGPKKDAKAAREFILYMFTSVNPDPYKCIYPHFTV 324
            :|||||||||:||.::||:.:||.||||||:||::||:|||||||.||..:|||..|.||.|||.
Mouse   266 NSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTC 330

  Fly   325 ATNTENIKFVFTAVKDTILELHLSETNLL 353
            ||:||||:|||.|||||||:|:|.|.||:
Mouse   331 ATDTENIRFVFAAVKDTILQLNLKEYNLV 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17760	NP_001036539.1	G_alpha	13..351	CDD:214595	218/338 (64%)
CG17760	NP_001036539.1	G-alpha	34..347	CDD:206639	205/313 (65%)
Gnaq	NP_032165.3	G-alpha	40..353	CDD:206639	205/313 (65%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	41..54		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	178..186		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	201..210		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	329..334		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S445
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D373878at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10218
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.840