DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaq and GNA14

DIOPT Version :9

Sequence 1:	NP_725192.2	Gene:	Galphaq / 36384	FlyBaseID:	FBgn0004435	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_004288.1	Gene:	GNA14 / 9630	HGNCID:	4382	Length:	355	Species:	Homo sapiens

Alignment Length:	393	Identity:	260/393 - (66%)
Similarity:	304/393 - (77%)	Gaps:	43/393 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKR 67
            ||||.|.||.:||:.|||:||||||:|||||||||||||||||||||||||||||||||||||::
Human     5 CCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRK 69

  Fly    68 GYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFEDPYLNAIKTLWDD 132
            |:.|||:||||.|||:||:|||.|:|.|...::.|.|.::..::.:.|:......:.|||.||.|
Human    70 GFTKLVYQNIFTAMQAMIRAMDTLRIQYVCEQNKENAQIIREVEVDKVSMLSREQVEAIKQLWQD 134

  Fly   133 AGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLEEIRFSY 197
            .||||||||||||||:|||||||.|:||:|.|:::||:||:||||||||||||||||||
Human   135 PGIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLE------ 193

  Fly   198 LSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHCFENVTS 262
                                                 .|:|||||||||||||||||||||:|||
Human   194 -------------------------------------NIIFRMVDVGGQRSERRKWIHCFESVTS 221

  Fly   263 IIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVD 327
            ||||||||||||:|.|.|||||||||||||:||||||||.|||||||||||||||||||||||:.
Human   222 IIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLNSSVILFLNKKDLLEEKIMYSHLIS 286

  Fly   328 YFPEYDGPQRDAITAREFILRMFVDLNPDSEKIIYSHFTCATDTENIKLVFCAVKDTIMQNALKE 392
            |||||.||::|...||:|||:::.|.|||.||:|||||||||||:||:.||.||||||:|..|:|
Human   287 YFPEYTGPKQDVRAARDFILKLYQDQNPDKEKVIYSHFTCATDTDNIRFVFAAVKDTILQLNLRE 351

  Fly   393 FNL 395
            |||
Human   352 FNL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	232/355 (65%)
GNA14	NP_004288.1	G_alpha	16..353	CDD:214595	250/379 (66%)
		G-alpha	36..349	CDD:206639	232/355 (65%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	37..50		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		6/7 (86%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		8/8 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	530	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	562	1.000	Inparanoid score	I1089
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	1	1.000	-	-		otm41322
orthoMCL	1	0.900	-	-		OOG6_104168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.770