Protein Alignment Galphaq and Gna12

DIOPT Version :10

• Sequence 1: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_112296.1
• Gene: Gna12 / 81663
• RGDID: 71018
• Length: 379
• Species: Rattus norvegicus
• Alignment Length: 412
• Identity: 153/412 - (37%)
• Similarity: 224/412 - (54%)
• Gaps: 63/412 - (15%)

  Fly     3 CCLSEEA--------------KEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQM 53
            |.|..||              :|.:|.:::|:..|.|::|..||.:|:||||.||||||||:|||
  Rat    11 CLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQM 75

  Fly    54 RIIHGSGYSDEDKRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYET---- 114
            |||||..:..:....:...:|.||....:.::.|.|.|.|.:...|:.:....:|:.:.:.
  Rat    76 RIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPV 140

  Fly   115 -VTTFEDPYLNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRV 178
             ..||: .|:.|:..||.|:||:|.:.||.|:||.:|.||:|.:|||:.
  Rat   141 EPATFQ-LYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIG---------------- 188

  Fly   179 PTTGIIEYPFDLEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDV 243
                                       |.:|.|::||||.||..|.||:|:.|.:..|.|:||||
  Rat   189 ---------------------------QLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDV 226

  Fly   244 GGQRSERRKWIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVIL 308
            |||||:|:||..||:.:|||:|:|:.|||||:|.|....||:.||..:|.||:....|.|.|:||
  Rat   227 GGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIIL 291

  Fly   309 FLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPDSEKIIYSHFTCATDTEN 373
            ||||.|||.||:....:..:||::.|........:.::::.|.....:..|.::.|||.|.||||
  Rat   292 FLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRGKPLFHHFTTAIDTEN 356

  Fly   374 IKLVFCAVKDTIMQNALKEFNL 395
            |:.||.||||||:|..||:..|
  Rat   357 IRFVFHAVKDTILQENLKDIML 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	138/360 (38%)
Gna12	NP_112296.1	G_alpha	40..377	CDD:214595	146/380 (38%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	57..70		10/12 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	198..206		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	221..230		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	290..297		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	349..354		2/4 (50%)