DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaq and GNAT3

DIOPT Version :9

Sequence 1:	NP_725192.2	Gene:	Galphaq / 36384	FlyBaseID:	FBgn0004435	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001095856.1	Gene:	GNAT3 / 346562	HGNCID:	22800	Length:	354	Species:	Homo sapiens

Alignment Length:	404	Identity:	177/404 - (43%)
Similarity:	230/404 - (56%)	Gaps:	68/404 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSEEAKEQKRINQEIEKQLRRD-KRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRG 68
            :|.|:||..:.::|:||:|:.| :||| |.:||||||.|||||||.:|||:|||.:|||:::...
Human     5 ISSESKESAKRSKELEKKLQEDAERDA-RTVKLLLLGAGESGKSTIVKQMKIIHKNGYSEQECME 68

  Fly    69 YIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSID----YETVTTFED----PYL-N 124
            :..:::.|...::.:::|||..|.|.|.....:|        |    |....|.||    |.| .
Human    69 FKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAE--------DQRQLYAMANTLEDGGMTPQLAE 125

  Fly   125 AIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFD 189
            .||.||.|.|||.|::|..||||.|||.|||.||||:....|:|.|||:|..||.||||||..|.
Human   126 VIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVKTTGIIETQFS 190

  Fly   190 LEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWI 254
            .:::.                                           |||.|||||||||:|||
Human   191 FKDLH-------------------------------------------FRMFDVGGQRSERKKWI 212

  Fly   255 HCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEK 319
            ||||.||.|||..|||.||.:|.|.:..|||.||..||.:|..:.:|..:|::|||||||:.:||
Human   213 HCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEK 277

  Fly   320 IMYSHLVDYFPEYDGPQ--RDAITAREFILRMFVDLNPDSE-KIIYSHFTCATDTENIKLVFCAV 381
            :...||...||||.||.  .|   |..:|...|:|||...| |.||||.||||||:|:|.||.||
Human   278 VTKVHLSICFPEYTGPNTFED---AGNYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAV 339

  Fly   382 KDTIMQNALKEFNL 395
            .|.|::..||:..|
Human   340 TDIIIKENLKDCGL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	161/367 (44%)
GNAT3	NP_001095856.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		8/21 (38%)
		G-alpha	34..348	CDD:206639	161/367 (44%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		7/8 (88%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R507
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850