DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaq and Gna13

DIOPT Version :9

Sequence 1:	NP_725192.2	Gene:	Galphaq / 36384	FlyBaseID:	FBgn0004435	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001013137.1	Gene:	Gna13 / 303634	RGDID:	1310221	Length:	377	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	164/404 - (40%)
Similarity:	233/404 - (57%)	Gaps:	56/404 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKR 67
            |.|:....||:|.::||:|.|.|:|...:|.:|:||||.||||||||:||||||||..:....:.
  Rat    18 CVLTNGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRARE 82

  Fly    68 GYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSID----------YETVTTFEDPY 122
            .:...::.|:...|:.::.|.:.|.|.:|..::....|.:|:.|          .||....:  |
  Rat    83 EFRPTIYSNVIKGMRVLVDAREKLHIPWGDNKNQVHGDKLMAFDTRAPMAAQGMVETRVFLQ--Y 145

  Fly   123 LNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYP 187
            |.||:.||||:|||..||||||:||.:|.||:|.:||::..|
  Rat   146 LPAIRALWDDSGIQNAYDRRREFQLGESVKYFLDNLDKLGVP----------------------- 187

  Fly   188 FDLEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRK 252
                                ||:|::||||.||.||.||.||.|::..:.|:|||||||||||::
  Rat   188 --------------------DYIPSQQDILLARRPTKGIHEYDFEIKNVPFKMVDVGGQRSERKR 232

  Fly   253 WIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLE 317
            |..||::||||:|||:.||:||:|.|....||:.||..:|.||:....|.|.|:||||||.||||
  Rat   233 WFECFDSVTSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLE 297

  Fly   318 EKIMYSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPD-SEKIIYSHFTCATDTENIKLVFCAV 381
            ||:....:.|||.|::|........::|::..|.....| .::.:|.|||.|.:||||:|||..|
  Rat   298 EKVQVVSIKDYFLEFEGDPHCLRDVQKFLVECFRGKRRDQQQRPLYHHFTTAINTENIRLVFRDV 362

  Fly   382 KDTIMQNALKEFNL 395
            ||||:.:.||:..|
  Rat   363 KDTILHDNLKQLML 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	149/366 (41%)
Gna13	NP_001013137.1	G_alpha	29..375	CDD:214595	159/390 (41%)
		G-alpha	49..371	CDD:206639	149/366 (41%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	50..63		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	195..203		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	218..227		7/8 (88%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	287..294		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	347..352		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820