Protein Alignment Galphaq and GNAT2

DIOPT Version :10

• Sequence 1: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_005263.1
• Gene: GNAT2 / 2780
• HGNCID: 4394
• Length: 354
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 174/396 - (43%)
• Similarity: 229/396 - (57%)
• Gaps: 54/396 - (13%)

  Fly     6 SEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGYI 70
            |.|.||..:.::|:||:|:.|.....:.:||||||.|||||||.:|||:|||..|||.|:...:.
Human     6 SAEDKELAKRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDGYSPEECLEFK 70

  Fly    71 KLVFQNIFMAMQSMIKAMDMLKISYGQ----GEHSELADLVMSIDYETVTTFEDPYL-NAIKTLW 130
            .:::.|:..::.::|:||..|.|.|.:    .:..:|.:|..||:..|:    .|.| ..|:.||
Human    71 AIIYGNVLQSILAIIRAMTTLGIDYAEPSCADDGRQLNNLADSIEEGTM----PPELVEVIRRLW 131

  Fly   131 DDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLEEIRF 195
            .|.|:|.|::|..||||.|||.|||..|:|:..|.|||:|||:||.||.||||||..|.::::.
Human   132 KDGGVQACFERAAEYQLNDSASYYLNQLERITDPEYLPSEQDVLRSRVKTTGIIETKFSVKDLN- 195

  Fly   196 SYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHCFENV 260
                                                      |||.|||||||||:|||||||.|
Human   196 ------------------------------------------FRMFDVGGQRSERKKWIHCFEGV 218

  Fly   261 TSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHL 325
            |.|||..|||.||.:|.|.|..|||.||..||.:|..:.:|..:|::||||||||.||||...||
Human   219 TCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEEKIKKVHL 283

  Fly   326 VDYFPEYDGPQRDAITAREFILRMFVDLNPDSE-KIIYSHFTCATDTENIKLVFCAVKDTIMQNA 389
            ...|||||| ......|..:|...|:|||...: |.||||.||||||:|:|.||.||.|.|::..
Human   284 SICFPEYDG-NNSYDDAGNYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKEN 347

  Fly   390 LKEFNL 395
            ||:..|
Human   348 LKDCGL 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	162/361 (45%)
GNAT2	NP_005263.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		8/20 (40%)
		G-alpha	34..348	CDD:206639	162/361 (45%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	173..181		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	196..205		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	265..272		5/6 (83%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)