DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Galphaq and GNAT1

DIOPT Version :9

Sequence 1:	NP_725192.2	Gene:	Galphaq / 36384	FlyBaseID:	FBgn0004435	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_000163.2	Gene:	GNAT1 / 2779	HGNCID:	4393	Length:	350	Species:	Homo sapiens

Alignment Length:	392	Identity:	170/392 - (43%)
Similarity:	230/392 - (58%)	Gaps:	52/392 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGYIKLV 73
            |..:::.::|:||:|:.|.....|.:||||||.|||||||.:|||:|||..|||.|:...:|.::
Human     5 ASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAII 69

  Fly    74 FQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVT--TFEDPYLNAIKTLWDDAGIQ 136
            :.|...::.::::||..|.|.||.....:.|..:|.: .:|:.  |......:.|:.||.|:|||
Human    70 YGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHM-ADTIEEGTMPKEMSDIIQRLWKDSGIQ 133

  Fly   137 ECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLEEIRFSYLSDL 201
            .|::|..||||.|||.|||.||:|:..|.|:|||||:||.||.||||||..|..:::.
Human   134 ACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLN------- 191

  Fly   202 ARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHCFENVTSIIFL 266
                                                |||.|||||||||:|||||||.||.|||:
Human   192 ------------------------------------FRMFDVGGQRSERKKWIHCFEGVTCIIFI 220

  Fly   267 VALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPE 331
            .|||.||.:|.|.|..|||.||..||.:|..:.:|..:|::|||||||:..|||..:||...||:
Human   221 AALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPD 285

  Fly   332 YDGPQ--RDAITAREFILRMFVDLNPDSE-KIIYSHFTCATDTENIKLVFCAVKDTIMQNALKEF 393
            ||||.  .|   |..:|...|::||...: |.||||.||||||:|:|.||.||.|.|::..||:.
Human   286 YDGPNTYED---AGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDC 347

  Fly   394 NL 395
            .|
Human   348 GL 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	160/360 (44%)
GNAT1	NP_000163.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		5/15 (33%)
		G-alpha	30..344	CDD:206639	160/360 (44%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	31..44		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	169..177		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	192..201		7/8 (88%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	261..268		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	320..325		4/4 (100%)
		Interaction with RHO. /evidence=ECO:0000250\|UniProtKB:P04695	340..350		3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820