Protein Alignment Galphaq and GNAI3

DIOPT Version :10

• Sequence 1: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_006487.1
• Gene: GNAI3 / 2773
• HGNCID: 4387
• Length: 354
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 181/400 - (45%)
• Similarity: 234/400 - (58%)
• Gaps: 52/400 - (13%)

  Fly     1 MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 65
            |.|.||.|.|.....::.|::.||.|...|.:|:||||||.|||||||.:|||:|||..|||:::
Human     1 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDE 65

  Fly    66 KRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHS----ELADLVMSIDYETVTTFEDPYLNAI 126
            .:.|..:|:.|...::.::|:||..|||.:|:...:    :|..|..|.: |.|.|.|  ....|
Human    66 CKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAE-EGVMTPE--LAGVI 127

  Fly   127 KTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLE 191
            |.||.|.|:|.|:.|.|||||.|||.|||.||||::|..|:||:||:||.||.||||:|..|..:
Human   128 KRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFK 192

  Fly   192 EIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHC 256
            :                                           :.|:|.|||||||||:|||||
Human   193 D-------------------------------------------LYFKMFDVGGQRSERKKWIHC 214

  Fly   257 FENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIM 321
            ||.||:|||.||||:||.:|.|.:..|||.||..||.:|....||..:|:|||||||||.||||.
Human   215 FEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIK 279

  Fly   322 YSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPDSE-KIIYSHFTCATDTENIKLVFCAVKDTI 385
            .|.|...:|||.| ......|..:|...|.|||...: |.||:||||||||:|::.||.||.|.|
Human   280 RSPLTICYPEYTG-SNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVI 343

  Fly   386 MQNALKEFNL 395
            ::|.|||..|
Human   344 IKNNLKECGL 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	165/360 (46%)
GNAI3	NP_006487.1	G-alpha	34..348	CDD:206639	165/360 (46%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	173..181		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	196..205		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	265..272		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)