Protein Alignment Galphaq and GNAI2

DIOPT Version :10

• Sequence 1: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_002061.1
• Gene: GNAI2 / 2771
• HGNCID: 4385
• Length: 355
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 180/399 - (45%)
• Similarity: 232/399 - (58%)
• Gaps: 49/399 - (12%)

  Fly     1 MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 65
            |.|.:|.|.|.....::.|:|.||.|...|.||:||||||.|||||||.:|||:|||..|||:|:
Human     1 MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEE 65

  Fly    66 KRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELAD--LVMSIDYETVTTFEDPYLNAIKT 128
            .|.|..:|:.|...::.:::|||..|:|.:.....::.|.  ..:|...|......|.....|:.
Human    66 CRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRR 130

  Fly   129 LWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLEEI 193
            ||.|.|:|.|:.|.|||||.|||.|||.||:|:|
Human   131 LWADHGVQACFGRSREYQLNDSAAYYLNDLERIA------------------------------- 164

  Fly   194 RFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHCFE 258
                        |:||:||:||:||.||.||||:|..|....:.|:|.|||||||||:|||||||
Human   165 ------------QSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFE 217

  Fly   259 NVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYS 323
            .||:|||.||||.||.:|.|.:..|||.||..||.:|....||.::|:|||||||||.||||.:|
Human   218 GVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHS 282

  Fly   324 HLVDYFPEYDGPQR-DAITAREFILRMFVDLNPDSE-KIIYSHFTCATDTENIKLVFCAVKDTIM 386
            .|...||||.|..: |  .|..:|...|.|||...: |.||:||||||||:|::.||.||.|.|:
Human   283 PLTICFPEYTGANKYD--EAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVII 345

  Fly   387 QNALKEFNL 395
            :|.||:..|
Human   346 KNNLKDCGL 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	164/359 (46%)
GNAI2	NP_002061.1	G-alpha	34..349	CDD:206639	164/359 (46%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	325..330		4/4 (100%)