Protein Alignment Galphaq and GNAI1

DIOPT Version :10

• Sequence 1: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_002060.4
• Gene: GNAI1 / 2770
• HGNCID: 4384
• Length: 354
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 180/401 - (44%)
• Similarity: 238/401 - (59%)
• Gaps: 54/401 - (13%)

  Fly     1 MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 65
            |.|.||.|.|.....::.|::.||.|...|.||:||||||.|||||||.:|||:|||.:|||:|:
Human     1 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEE 65

  Fly    66 KRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFEDPYLNA----- 125
            .:.|..:|:.|...::.::|:||..|||.:|....::.|..:    :......|:.::.|
Human    66 CKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQL----FVLAGAAEEGFMTAELAGV 126

  Fly   126 IKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDL 190
            ||.||.|:|:|.|::|.|||||.|||.|||.||||:|||.|:||:||:||.||.||||:|..|..
Human   127 IKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTF 191

  Fly   191 EEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIH 255
            :::.                                           |:|.|||||||||:||||
Human   192 KDLH-------------------------------------------FKMFDVGGQRSERKKWIH 213

  Fly   256 CFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKI 320
            |||.||:|||.||||:||.:|.|.:..|||.||..||.:|....||.::|:|||||||||.||||
Human   214 CFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKI 278

  Fly   321 MYSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPDSE-KIIYSHFTCATDTENIKLVFCAVKDT 384
            ..|.|...:|||.| ......|..:|...|.|||...: |.||:||||||||:|::.||.||.|.
Human   279 KKSPLTICYPEYAG-SNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDV 342

  Fly   385 IMQNALKEFNL 395
            |::|.||:..|
Human   343 IIKNNLKDCGL 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	164/361 (45%)
GNAI1	NP_002060.4	G-alpha	34..348	CDD:206639	164/361 (45%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	173..181		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	196..205		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	265..272		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)