Protein Alignment Galphaq and GNA11

DIOPT Version :9

• Sequence 1: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_002058.2
• Gene: GNA11 / 2767
• HGNCID: 4379
• Length: 359
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 287/395 - (72%)
• Similarity: 318/395 - (80%)
• Gaps: 43/395 - (10%)

  Fly     1 MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 65
            |.||||:|.||.||||.|||||||||||||||||||||||||||||||||||||||||:|||:||
Human     7 MACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEED 71

  Fly    66 KRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFEDPYLNAIKTLW 130
            |||:.|||:||||.|||:||:||:.|||.|...::...|.|:..:|.|.|||||..|::||||||
Human    72 KRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLW 136

  Fly   131 DDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLEEIRF 195
            :|.||||||||||||||:|||||||.|:||:|...||||:||:||||||||||||||||||
Human   137 EDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLE---- 197

  Fly   196 SYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHCFENV 260
                                                   .|:|||||||||||||||||||||||
Human   198 ---------------------------------------NIIFRMVDVGGQRSERRKWIHCFENV 223

  Fly   261 TSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHL 325
            |||:||||||||||:|.||||||||||||||||||||||||||||||||||||||||:||:||||
Human   224 TSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHL 288

  Fly   326 VDYFPEYDGPQRDAITAREFILRMFVDLNPDSEKIIYSHFTCATDTENIKLVFCAVKDTIMQNAL 390
            ||||||:|||||||..||||||:|||||||||:||||||||||||||||:.||.||||||:|..|
Human   289 VDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNL 353

  Fly   391 KEFNL 395
            ||:||
Human   354 KEYNL 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	254/355 (72%)
GNA11	NP_002058.2	G-alpha	40..353	CDD:206639	254/355 (72%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	41..54		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	178..186		6/7 (86%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	201..210		8/8 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	329..334		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	530	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	562	1.000	Inparanoid score	I1089
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	1	1.000	-	-		otm41322
orthoMCL	1	0.900	-	-		OOG6_104168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.730