Protein Alignment Galphaq and Gnas

DIOPT Version :10

• Sequence 1: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_034439.2
• Gene: Gnas / 14683
• MGIID: 95777
• Length: 1133
• Species: Mus musculus
• Alignment Length: 429
• Identity: 158/429 - (36%)
• Similarity: 230/429 - (53%)
• Gaps: 87/429 - (20%)

  Fly     8 EAKEQKRINQE----IEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGY------- 61
            |.:||||.:::    |:|||..:|.|.....:|||||.|||||||.:|||||:|.:|:
Mouse   750 EMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEE 814

  Fly    62 --------SDEDKRGYIKLVFQNIFMAMQSMIKAMDML--KISYGQGEHSELADLVMSIDYETVT 116
                    ||.:|...::.:..|:..|:::::.||..|  .:.....|:....|.::|:  ..|.
Mouse   815 DPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSV--MNVP 877

  Fly   117 TFEDP--YLNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVP 179
            .|:.|  :....|.||:|.|::.||:|..||||.|.|:|:|..:|
Mouse   878 NFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKID-------------------- 922

  Fly   180 TTGIIEYPFDLEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVG 244
                                   .|:||||:|::||:||.||.|:||.|..|.:|.:.|.|.|||
Mouse   923 -----------------------VIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVG 964

  Fly   245 GQRSERRKWIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILF 309
            |||.||||||.||.:||:|||:||.|.|:.::.|.:..||::|:..||::|....|.:..|||||
Mouse   965 GQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILF 1029

  Fly   310 LNKKDLLEEKIM--YSHLVDYFPE---YDGPQRDA---------IT-AREFILRMFVDLNP---D 356
            |||:|||.||::  .|.:.|||||   |..|: ||         :| |:.||...|:.::.   |
Mouse  1030 LNKQDLLAEKVLAGKSKIEDYFPEFARYTTPE-DATPEPGEDPRVTRAKYFIRDEFLRISTASGD 1093

  Fly   357 SEKIIYSHFTCATDTENIKLVFCAVKDTIMQNALKEFNL 395
            .....|.|||||.|||||:.||...:|.|.:..|:::.|
Mouse  1094 GRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYEL 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	145/392 (37%)
Gnas	NP_034439.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..195
		PHA03247	<50..496	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..552
		PRK12323	<330..531	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..648
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..744
		UDM1_RNF168_RNF169-like	730..>772	CDD:409016	9/21 (43%)
		G-alpha	780..1127	CDD:206639	145/392 (37%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	781..794		10/12 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..828		2/20 (10%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	935..943		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	958..967		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	1027..1034		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	1103..1108		3/4 (75%)