Protein Alignment Galphaq and Gna12

DIOPT Version :9

• Sequence 1: NP_725192.2
• Gene: Galphaq / 36384
• FlyBaseID: FBgn0004435
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_034432.1
• Gene: Gna12 / 14673
• MGIID: 95767
• Length: 379
• Species: Mus musculus
• Alignment Length: 412
• Identity: 153/412 - (37%)
• Similarity: 224/412 - (54%)
• Gaps: 63/412 - (15%)

  Fly     3 CCLSEEA--------------KEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQM 53
            |.|..||              :|.:|.:::|:..|.|::|..||.:|:||||.||||||||:|||
Mouse    11 CLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQM 75

  Fly    54 RIIHGSGYSDEDKRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYET---- 114
            |||||..:..:....:...:|.||....:.::.|.|.|.|.:...|:.:....:|:.:.:.
Mouse    76 RIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPV 140

  Fly   115 -VTTFEDPYLNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRV 178
             ..||: .|:.|:..||.|:||:|.:.||.|:||.:|.||:|.:|||:.
Mouse   141 EPATFQ-LYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIG---------------- 188

  Fly   179 PTTGIIEYPFDLEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDV 243
                                       |.:|.|::||||.||..|.||:|:.|.:..|.|:||||
Mouse   189 ---------------------------QLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDV 226

  Fly   244 GGQRSERRKWIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVIL 308
            |||||:|:||..||:.:|||:|:|:.|||||:|.|....||:.||..:|.||:....|.|.|:||
Mouse   227 GGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIIL 291

  Fly   309 FLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPDSEKIIYSHFTCATDTEN 373
            ||||.|||.||:....:..:||::.|........:.::::.|.....:..|.::.|||.|.||||
Mouse   292 FLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTEN 356

  Fly   374 IKLVFCAVKDTIMQNALKEFNL 395
            |:.||.||||||:|..||:..|
Mouse   357 IRFVFHAVKDTILQENLKDIML 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	138/360 (38%)
Gna12	NP_034432.1	G_alpha	40..377	CDD:214595	146/380 (38%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	57..70		10/12 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	198..206		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	221..230		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	290..297		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	349..354		2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820