DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amph and Bin2

DIOPT Version :9

Sequence 1:	NP_523717.1	Gene:	Amph / 36383	FlyBaseID:	FBgn0027356	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001257466.1	Gene:	Bin2 / 668218	MGIID:	3611448	Length:	505	Species:	Mus musculus

Alignment Length:	532	Identity:	165/532 - (31%)
Similarity:	244/532 - (45%)	Gaps:	105/532 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MLAKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIRCVRAAQA 72
            :.||.:||...||:||:||.|||...|.||.|:...:||.:|||..::|.|:..|::..|:....
Mouse    12 LFAKQMQKKFSRAQEKVLQKLGKTVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHE 76

  Fly    73 ASKTLMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPEMKKKVEK 137
            :||.:.:::.|:|...|.|::.|:|..|.::.||.|:..||.||.|..:..|..||.|:|:::.|
Mouse    77 SSKRVSETLQEVYSSDWDGHEDLKAIVGNNDLLWEDYEEKLADQALRTMENYVSQFSEIKERIAK 141

  Fly   138 RNRKLIDYDGQRHSFQNLQANANKRKDDVKLTKGREQLEEARRTYEILNTELHDELPALYDSRIL 202
            |.|||:|||..||..:.:| || |:|||.|:.|..|...:|:..:|.||.||.:|||.||:|||.
Mouse   142 RGRKLVDYDSARHHLEAVQ-NA-KKKDDAKMAKAEEDFSKAQIVFEDLNQELLEELPILYNSRIG 204

  Fly   203 FLVTNLQTLFATEQVFHNETAKIYSELEAIVDKLATESQRG---------SNTLRKQ-------- 250
            ..||..|.:.....||:.|.:|:...|..::.||  |.|..         |::.|:.
Mouse   205 CYVTVFQNISNLRDVFYREMSKLNHNLYEVMSKL--EKQHSNKVFVVKGLSSSSRRSLVISPPVQ 267

  Fly   251 ---TSNPIKTSSPVQSPVNKLNNANINSNYQNQITTN-------GGSSLANSPTS---------- 295
               .|:|:...||| |||....:.:..|..::...|.       ||.....|..|
Mouse   268 SCAASSPVSPVSPV-SPVTSPTSPSATSEPESVSATGEELTSEAGGEDSCESQESLKDEEADEAQ 331

  Fly   296 --TSSSLQEPRFDS-----------VSSTPEPRPESPAAALVSATPSSPVENGVTTKSLERPELS 347
              ||||.:|...|.           ..:.|.|.|.||||.:.|                   :..
Mouse   332 SETSSSEEEDEEDEEDEEDEEEPLPACNGPTPAPASPAAEVGS-------------------QEE 377

  Fly   348 GLNASAKATTTTQT---SPTEDKAVVSEAVKPSETEGAAVAASV--TPAPPATP----AQINGNN 403
            .|::||::....||   :|:....|:.........|.:..|||:  |.|||:.|    |..:|:.
Mouse   378 ALSSSAQSPGRGQTGKDTPSPGDVVLRARASSEGAEQSKRAASIQRTSAPPSRPPPPRASGSGSC 442

  Fly   404 NEPSIVKEGGKQ---PKELPSTTSNAEAA----AEAAANNGNSIEEHKQKKLGNDTTVTATETVT 461
            |.|. ..||..|   |:..|..:||.|.|    .|.|.::|.  ||.:           |..|.:
Mouse   443 NAPG-SPEGSSQLCSPRASPDASSNPEPAETREKEGAGSSGP--EEPR-----------AVSTKS 493

  Fly   462 VTQHSVTSTDTD 473
            .|| ..||.:|:
Mouse   494 ATQ-VFTSENTE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	83/211 (39%)
Amph	NP_523717.1	SH3_Amphiphysin	539..602	CDD:212724
Bin2	NP_001257466.1	BAR	30..240	CDD:299863	83/213 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834721
Domainoid	1	1.000	188	1.000	Domainoid score	I3307
eggNOG	1	0.900	-	-		E1_KOG3771
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1366218at2759
OrthoFinder	1	1.000	-	-		FOG0001177
OrthoInspector	1	1.000	-	-		otm42339
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1098
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.850