Protein Alignment Amph and Amph

DIOPT Version :10

• Sequence 1: NP_523717.1
• Gene: Amph / 36383
• FlyBaseID: FBgn0027356
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: XP_063132789.1
• Gene: Amph / 60668
• RGDID: 620274
• Length: 848
• Species: Rattus norvegicus
• Alignment Length: 878
• Identity: 209/878 - (23%)
• Similarity: 335/878 - (38%)
• Gaps: 311/878 - (35%)

  Fly     1 MTENKGIMLAKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIR 65
            |.:.|..:.||:|||...||:||:||.|||.|.|.||.|::::.||.||:|...|||:|...|:.
  Rat     1 MADIKTGIFAKNVQKRLNRAQEKVLQKLGKADETKDEQFEEYVQNFKRQEAEGTRLQRELRGYLA 65

  Fly    66 CVRAAQAASKTLMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPE 130
            .::..|.||..|.:|:.|:|||.|.|.:.::......:.||.||..||.|..|:.|:||.||||:
  Rat    66 AIKGMQEASMKLTESLHEVYEPDWYGREDVKMVGEKCDVLWEDFHQKLVDGSLLTLDTYLGQFPD 130

  Fly   131 MKKKVEKRNRKLIDYDGQRHSFQNLQANANKRKDDVKLTKGREQLEEARRTYEILNTELHDELPA 195
            :|.::.||:|||:|||..||..:.||  ::||||:.:::|..|:.::|::.:|..|.:|.:|||:
  Rat   131 IKNRIAKRSRKLVDYDSARHHLEALQ--SSKRKDESRISKAEEEFQKAQKVFEEFNVDLQEELPS 193

  Fly   196 LYDSRILFLVTNLQTLFATEQVFHNETAKIYSELEAIVDKLATE------------SQRG----- 243
            |:..|:.|.|...:.:.:.|..||.|.|.:..:|..::.||..:            |..|
  Rat   194 LWSRRVGFYVNTFKNVSSLEAKFHKEIAVLCHKLYEVMTKLGDQHADKAFSIQGAPSDSGPLRIA 258

  Fly   244 -------------------SNTLRKQTSNPIKTSSPVQ-------------SPVNKLNNANI--- 273
                               ::||...:..|::..||.|             :|..:|...||
  Rat   259 KTPSPPEEASPLPSPTASPNHTLAPASPAPVRPRSPSQTRKGPPVPPLPKVTPTKELQQENIINF 323

  Fly   274 -NSNY----------QNQ---------------------ITTNGGSSLANSPTS---------TS 297
             ..|:          ||:                     :|..|.::..:||.|         ||
  Rat   324 FEDNFVPEINVTTPSQNEVLEVKKEETLLDLDFDPFKPDVTPAGSAAATHSPMSQTLPWDLWTTS 388

  Fly   298 SSLQEPRFDSVSSTPEPRPESPAAALVSATPSSPVENGVTTKSLERPELS------GLNASAKAT 356
            :.|.:|       |...:..|....::..||:|.:     .:.::|.|..      |.:|...:.
  Rat   389 TDLVQP-------TDSSKSLSMCNLIMEETPNSGL-----AEEIQRYETDIGAFTWGPHARTDSV 441

  Fly   357 --TTTQTSPTEDKAVVSEAVKP--------SETEGAAVAASVTPAPPATPAQING---------- 401
              ..|.:...||.|.:|||.:.        |..:.:.:|.....:|||...|::.
  Rat   442 RQEMTPSESREDIACLSEAERDMRLSTGMLSSADCSTLAGQGEDSPPARNEQLSSEPVPGAGVTI 506

  Fly   402 ----NNNEP--------------SIVKEGGKQPK------------------------------- 417
                ..::|              .::|||.::.|
  Rat   507 PTCMETDQPYALLDSEIPAIGKVDLLKEGHEEAKISDGEIKQKQKVEDLMWGCASGGSFNDFTQP 571

  Fly   418 ---------------------------ELPSTTSNAEAAAEAAANNGNSIEEHKQKKL---GNDT 452
                                       |.|.||:   ||..|..:.|..:||.|::..   |.|.
  Rat   572 QDTSLFTMQTDQNMAETEQALPTEPQAEEPPTTA---AAPTAGLDLGLEMEEPKEEAAIPPGTDA 633

  Fly   453 TVT-ATE-------------------------TVTVTQHSVTSTDTDNIVTI------------- 478
            ..| .||                         .:.|....:.|:::.....:
  Rat   634 GETVGTEGSPGEEAEAEKAALPAGEGESPEGAKIDVESTELASSESPQAAELEAGAPQEKVIPSV 698

  Fly   479 -------------SDTNTDTDTKTST---------GTSQK--GRPVPVVNRHSVNNLNKNPFEDD 519
                         .:|.|.|:|:.:|         |..|:  ..|.|:                |
  Rat   699 VIEPASNHEGEEHQETTTGTETREATEDVAPQGPAGEKQELATEPTPL----------------D 747

  Fly   520 DERIYEVPADANTA---------DLPPGVLYRVKATYGYAKEDVDELSFEIGDLIRVIEYDDPED 575
            .:.....||.|..|         :||||.||:|:..:.:...:.|||:.:.||::.|:..|...|
  Rat   748 SQAATPAPAGAVDASLSAGDAAQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEAD 812

  Fly   576 QEEGWLMGQKEG--------TNEKGLFPANFTR 600
            |:.|||:|.||.        ...|||||.||||
  Rat   813 QDAGWLVGVKESDWLQYRDLATYKGLFPENFTR 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	83/211 (39%)
		PTZ00449	<275..>396	CDD:185628	33/176 (19%)
		SH3_Amphiphysin	539..602	CDD:212724	27/70 (39%)
Amph	XP_063132789.1	None