Protein Alignment Amph and bin2b

DIOPT Version :10

• Sequence 1: NP_523717.1
• Gene: Amph / 36383
• FlyBaseID: FBgn0027356
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: NP_956090.1
• Gene: bin2b / 327387
• ZFINID: ZDB-GENE-030131-5598
• Length: 524
• Species: Danio rerio
• Alignment Length: 594
• Identity: 161/594 - (27%)
• Similarity: 258/594 - (43%)
• Gaps: 130/594 - (21%)

  Fly     8 MLAKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIRCVRAAQA 72
            :|||..||...||:||:||.|||...|.||.|::...|.|:||....||.|:...|...|:....
Zfish    20 ILAKRFQKSMNRAQEKVLQKLGKTMETKDEQFEECSANLNKQQTDGIRLYKDVKAYYNAVKVMHE 84

  Fly    73 ASKTLMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPEMKKKVEK 137
            :||.|..::.:||||.|.|.:.|.....:.:.||.|:..||.|||:..:..||.||.::|::|.|
Zfish    85 SSKRLSQTLKDIYEPDWHGVEDLTVIMESEDLLWNDYEEKLNDQVVRTMENYTAQFQDVKERVAK 149

  Fly   138 RNRKLIDYDGQRHSFQNLQANANKRKDDVKLTKGREQLEEARRTYEILNTELHDELPALYDSRIL 202
            |.|||:|||..||..:.||  :.|::||.|:.|..|:..:|:..:|.:|.||.:|||.||.|||.
Zfish   150 RGRKLVDYDSTRHHLEALQ--SAKKRDDAKVNKAEEEFNKAQEVFEDINKELREELPVLYQSRIS 212

  Fly   203 FLVTNLQTLFATEQVFHNETA----KIYSELEAIVDKLATES--QRGSNTLRKQTSNPIKTSSPV 261
            ..||..|.:.....||:.|.:    .||:.::.:.|:.:|:.  .:|.|:.:.:....:..|:|:
Zfish   213 CYVTMFQNISNLRDVFYKEMSMLNHNIYNMMKKLEDQHSTKPFIVKGLNSSKSKKRKSVTISAPI 277

  Fly   262 QSPVNKLNNANINSNYQNQITTNGGSSLANSPT-----STSSSLQEPRFDSVSSTPEPRPESPAA 321
            ..      |....:::......:...:||::.|     |.|:.:.|...||..|.|.
Zfish   278 PC------NTAFPTDHPAMSKLSMPDTLAHTDTRIHTPSKSTEISESESDSFDSEPN-------- 328

  Fly   322 ALVSATPSSPVENGVTTKSLERPELSGLNASAKATTTTQTSPTEDKAVVSEAVKPSETEGAAVAA 386
                 ||             :|..|..:.:...:..|  :..|.|:.|
Zfish   329 -----TP-------------KRQSLCSVRSDGASENT--SGSTTDEIV----------------- 356

  Fly   387 SVTPAPPATPAQINGNNNEPSIVKEGGKQPKELPSTTSNAEAAAEAAANNGNSIEEHKQKKLGND 451
                       |.||..::.|:..|  :|.:|   .:.:::||:...|:|
Zfish   357 -----------QANGQEHQDSVSVE--RQEEE---ESKSSQAASSEDAHN--------------- 390

  Fly   452 TTVTATETVTVTQHSVTSTDTDNIVTISDTNTDTDTKTSTGTSQKGRPVPVVNRHSVNNLNKNPF 516
                            .|||.|:           .||..:....|..|:|...|.|.:..::...
Zfish   391 ----------------ASTDGDD-----------QTKLLSADEDKPAPIPTPRRSSTSKKDEGET 428

  Fly   517 EDDDERIYEVPADANTA-DLPPGVLYRVKATYGYAKEDVDE---LSFEIGDLIRVIEYDDPEDQE 577
            :::.:...|...:..|. :.|||.||:..|   ...:|.||   |.||.||||... .||.|::.
Zfish   429 DENTKGSSEDVKEQKTEYENPPGFLYKAVA---LKSQDSDEGVLLLFEKGDLILTF-VDDEEEKP 489

  Fly   578 EGWLMGQKE 586
            :|::.|.:|
Zfish   490 DGFVWGVRE 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	81/215 (38%)
		PTZ00449	<275..>396	CDD:185628	18/125 (14%)
		SH3_Amphiphysin	539..602	CDD:212724	19/51 (37%)
bin2b	NP_956090.1	BAR_Bin2	38..248	CDD:153296	80/211 (38%)
		SH3	452..522	CDD:473055	19/51 (37%)