DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amph and bin3

DIOPT Version :9

Sequence 1:	NP_523717.1	Gene:	Amph / 36383	FlyBaseID:	FBgn0027356	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001116516.1	Gene:	bin3 / 323976	ZFINID:	ZDB-GENE-030131-2696	Length:	253	Species:	Danio rerio

Alignment Length:	272	Identity:	64/272 - (23%)
Similarity:	119/272 - (43%)	Gaps:	47/272 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIRCVRAAQAASKT------ 76
            |:.:::|      |.:|.:..|:.......:.:....:|.|:..   :...|..|.||.
Zfish     9 GQPRKQI------VSKTVERDFEREYEKLQKLEEQTKKLHKDMK---KSTEADLAMSKAAVKISG 64

  Fly    77 --LMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPEMKKKVEKRN 139
              |.:.:||..:......:||.......::...:..:::...|:.||..|...||.:...|::|.
Zfish    65 DLLSNPLCEQDQHFLDSMNALDTAMKRMDAFNQEKVNQIQKTVIDPLKKYGSVFPSLNMAVKRRE 129

  Fly   140 RKLIDYDGQRHSFQNLQANANKRKDD-------VKLTKGREQLEEARRTYEILNTELHDELPALY 197
            :.|.||       :.||:...|.::.       |||.:.||:|:..|..:|..|.:|.||:|..|
Zfish   130 QALQDY-------KRLQSKVEKYEEKEKTGPIMVKLHQAREELKPVREDFEAKNKQLLDEMPKFY 187

  Fly   198 DSRILFLVTNLQTLFATEQVFHNETAKIYSELEAIVDKLA-TESQRGSNTLRKQTSNPIKTSSPV 261
            :|||.:...:.:.|...:.|:..|..||::||...:|:.| |:.|      |||.:
Zfish   188 NSRIDYFQPSFEALIRAQVVYFTEMHKIFTELNDQIDQSALTDEQ------RKQEN--------- 237

  Fly   262 QSPVNKLNNANI 273
            ::.:|:|.:.:|
Zfish   238 EAKLNELRSLSI 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	54/227 (24%)
Amph	NP_523717.1	SH3_Amphiphysin	539..602	CDD:212724
bin3	NP_001116516.1	BAR_Bin3	12..236	CDD:153274	59/245 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910