DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amph and BIN1

DIOPT Version :9

Sequence 1:	NP_523717.1	Gene:	Amph / 36383	FlyBaseID:	FBgn0027356	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_647593.1	Gene:	BIN1 / 274	HGNCID:	1052	Length:	593	Species:	Homo sapiens

Alignment Length:	697	Identity:	201/697 - (28%)
Similarity:	299/697 - (42%)	Gaps:	208/697 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NKGI---MLAKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIR 65
            :||:   .:|.:|||...||:||:||.|||.|.|.||.|:..:.|||:|.....||||:...|:.
Human     6 SKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLA 70

  Fly    66 CVRAAQAASKTLMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPE 130
            .|:|...|||.|.:.:.|:|||.|.|.|........::.||.|:..||.||.|:.::||.||||:
Human    71 SVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPD 135

  Fly   131 MKKKVEKRNRKLIDYDGQRHSFQNLQANANKRKDDVKLTK------------------------- 170
            :|.::.||.|||:|||..||.:::||  ..|:||:.|:.|
Human   136 IKSRIAKRGRKLVDYDSARHHYESLQ--TAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQT 198

  Fly   171 ------GREQLEEARRTYEILNTELHDELPALYDSRILFLVTNLQTLFATEQVFHNETAKIYSEL 229
                  ..|:|.:|::.:|.:|.:|.:|||:|::||:.|.|...|::...|:.||.|.:|:...|
Human   199 NLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNL 263

  Fly   230 EAIVDKLATESQRGSN--TLRKQTSN--PIK--------TSSPVQSPVNKLNNANINSNYQNQIT 282
            ..::  :..|.|.|||  |::.|.|:  |.|        ..||..:|       .|..|::.: .
Human   264 NDVL--VGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATP-------EIRVNHEPE-P 318

  Fly   283 TNGGSSLANSPTSTSSSLQEPRFDSVSSTPEPRPESPAAALVSATPSSPV--------------- 332
            ..|.:..|..|.|.|...:.|          |.|..|     ..|||..|
Human   319 AGGATPGATLPKSPSQLRKGP----------PVPPPP-----KHTPSKEVKQEQILSLFEDTFVP 368

  Fly   333 ENGVTTKS----------------LERPELSGLNASAKATTTTQTS-------PTEDKAVVSEAV 374
            |..|||.|                |:...|..:.:..||.|.:..|       |||..|....:.
Human   369 EISVTTPSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLPSG 433

  Fly   375 KPSETEGA-AVA-----ASVTPAPPATPAQINGNNNEPSIVKEGGKQPKELPSTTSNAEAAAEAA 433
            :||..||. ||:     |...||.||..:::.| ..:|:   .|.::|.|        .||:|||
Human   434 EPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAG-GTQPA---AGAQEPGE--------TAASEAA 486

  Fly   434 ANNGNSIEEHKQKKLGNDTTVTATETVTVTQHSVTSTDTDNIVTISDTNTDTDTKTSTGTSQKGR 498
            :                    ::...|.|                     :|...|..||.:.|
Human   487 S--------------------SSLPAVVV---------------------ETFPATVNGTVEGG- 509

  Fly   499 PVPVVNRHSVNNLNKNPFEDDDERIYEVPADANTADLPPGVLYRVKATYGYAKEDVDELSFEIGD 563
                                         :.|...|||||.:::|:|.:.|...|.|||..:.||
Human   510 -----------------------------SGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGD 545

  Fly   564 LIRVIEYDDPEDQEEGWLMGQKEGT-NE-------KGLFPANFTRPI 602
            ::.||.:.:||:|:||||||.||.. |:       :|:||.|||..:
Human   546 VVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERV 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	84/242 (35%)
Amph	NP_523717.1	SH3_Amphiphysin	539..602	CDD:212724	29/70 (41%)
BIN1	NP_647593.1	Interaction with BIN2. /evidence=ECO:0000269\|PubMed:10903846	2..122		48/115 (42%)
		BAR_Amphiphysin_I_II	31..272	CDD:153295	84/244 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..354		22/96 (23%)
		Clathrin-binding	378..421		6/42 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..488		29/119 (24%)
		SH3_Bin1	521..592	CDD:213015	29/70 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144602
Domainoid	1	1.000	186	1.000	Domainoid score	I3353
eggNOG	1	0.900	-	-		E1_KOG3771
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	249	1.000	Inparanoid score	I3247
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1366218at2759
OrthoFinder	1	1.000	-	-		FOG0001177
OrthoInspector	1	1.000	-	-		otm40272
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46514
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R565
SonicParanoid	1	1.000	-	-		X1098
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890