DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amph and hob3

DIOPT Version :9

Sequence 1:	NP_523717.1	Gene:	Amph / 36383	FlyBaseID:	FBgn0027356	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_595489.1	Gene:	hob3 / 2541160	PomBaseID:	SPBC725.09c	Length:	264	Species:	Schizosaccharomyces pombe

Alignment Length:	272	Identity:	74/272 - (27%)
Similarity:	123/272 - (45%)	Gaps:	24/272 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIRCVRAAQAASKTLM 78
            :|...||...::...|.|:||.|..|:.....:...:::|.:||||...|:..:||..|:...:.
pombe     7 KKAVNRAGTSVMMKTGHVERTVDREFETEERRYRTMESAAKKLQKEAKGYLDALRAMTASQTRIA 71

  Fly    79 DSVCEIYEPQWS--GYDALQAQTGASESLWADFAHKLG----DQVLIPLNTYTGQFPEMKKKVEK 137
            :::...|....|  |..|...|  ..|.|.||...:|.    ..||.|::.:...||::...:.|
pombe    72 NTIDAFYGDAGSKDGVSAYYRQ--VVEDLDADTVKELDGPFRTTVLDPISRFCSYFPDINAAITK 134

  Fly   138 RNRKLIDYDGQRHSFQNLQANANKRKDDVKLTKGREQLEEARRTYEILNTELHDELPALYDSRIL 202
            ||.||:|:|..|...|.|....:  .|..||.:..::...|:..||.||.:|..|||.|...|:.
pombe   135 RNHKLLDHDAMRAKVQKLVDKPS--NDTTKLPRTEKEAAMAKEVYETLNNQLVSELPQLIALRVP 197

  Fly   203 FLVTNLQTLFATEQVFHNETAKIYSELEAIVDKLATESQRGSNTLRKQTSNPI---KTSSPVQSP 264
            :|..:.:.|...:..|..|.          .:|:|...|...|::|:..||.:   |....:||
pombe   198 YLDPSFEALVKIQLRFCREG----------YEKMAQVQQYFDNSVREDYSNGLLDDKVEQVLQS- 251

  Fly   265 VNKLNNANINSN 276
            :..|:.|.:|::
pombe   252 MRDLSIAGLNNS 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	59/217 (27%)
Amph	NP_523717.1	SH3_Amphiphysin	539..602	CDD:212724
hob3	NP_595489.1	BAR_Rvs161p	20..241	CDD:153275	65/234 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	88	1.000	Domainoid score	I2125
eggNOG	1	0.900	-	-		E1_KOG3771
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46972
orthoMCL	1	0.900	-	-		OOG6_105748
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R565
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740