DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amph and Amph

DIOPT Version :9

Sequence 1:	NP_523717.1	Gene:	Amph / 36383	FlyBaseID:	FBgn0027356	Length:	602	Species:	Drosophila melanogaster
Sequence 2:	NP_001276475.1	Gene:	Amph / 218038	MGIID:	103574	Length:	690	Species:	Mus musculus

Alignment Length:	752	Identity:	204/752 - (27%)
Similarity:	320/752 - (42%)	Gaps:	217/752 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTENKGIMLAKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIR 65
            |.:.|..:.||:|||...||:||:||.|||.|.|.||.|::::.||.||:|...|||:|...|:.
Mouse     1 MADIKTGIFAKNVQKRLNRAQEKVLQKLGKADETKDEQFEEYVQNFKRQEAEGTRLQRELRGYLA 65

  Fly    66 CVRAAQAASKTLMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPE 130
            .::..|.||..|.:|:.|:|||.|.|.:.::......:.||.||..||.|..|:.|:||.||||:
Mouse    66 AIKGMQEASMKLTESLHEVYEPDWYGREDVKMVGEKCDVLWEDFHQKLVDGSLLTLDTYLGQFPD 130

  Fly   131 MKKKVEKRNRKLIDYDGQRHSFQNLQANANKRKDDVKLTKGREQLEEARRTYEILNTELHDELPA 195
            :|.::.||:|||:|||..||..:.||  ::||||:.:::|..|:.::|::.:|..|.:|.:|||:
Mouse   131 IKNRIAKRSRKLVDYDSARHHLEALQ--SSKRKDESRISKAEEEFQKAQKVFEEFNVDLQEELPS 193

  Fly   196 LYDSRILFLVTNLQTLFATEQVFHNETAKIYSELEAIVDKLATE------------SQRG----- 243
            |:.||:.|.|...:.:.:.|..||.|.|.:..:|..::.||..:            |..|
Mouse   194 LWSSRVGFYVNTFKNVSSLEAKFHKEIAVLCHKLYEVMTKLGDQHADKAFSIQGAPSDSGPLRIA 258

  Fly   244 -------------------SNTLRKQTSNPIKTSSPVQ-------------SPVNKLNNANI--- 273
                               ::||...:..|::..||.|             :|..:|...||
Mouse   259 KTPSPPEEPSPLPSPTASPNHTLAPASPAPVRPRSPSQTRKGPPVPPLPKVTPTKELKQENIINF 323

  Fly   274 -NSNY----------QNQ---------------------ITTNGGSSLANSPTS---------TS 297
             ..|:          ||:                     :...|.::..:||.|         ||
Mouse   324 FEDNFVPEINVTTPSQNEVLEVKKEETLLDLDFDPFKPDVAPAGSAAATHSPMSQTLPWDLWTTS 388

  Fly   298 SSLQEPR-------FDSVSST-----------------------PEPRPESPAAALVSATPSSPV 332
            :.|.:|.       |.....|                       .||:.|.|.|  .:|.|::.:
Mouse   389 TDLVQPASGGSFNDFTQAQDTSLFTMQTDQNMVGGLAETEQALPTEPQAEEPPA--TAAAPTAGL 451

  Fly   333 ENGVTTKSLERPELSGLNASAKATTTTQTSPTEDKAVVSEA--VKPSETEGAAVAASVTPAPPAT 395
            :.|:   .:|.|:     ..|.....|.|..|.:.||.:|.  |:.:|.|.||:.|....:|..
Mouse   452 DLGL---EMEEPK-----EEAVIPPATDTGETVETAVPTEGAPVEEAEAEKAALPAGEGGSPEG- 507

  Fly   396 PAQINGNNNE------PSIVKEGGKQPKELPSTTSNAEAAAEAAANNGNSIEEHKQKKLGNDTTV 454
             |:|:|.:.|      |..|:.....|:.:||      ...|.|:|:... .||::       |.
Mouse   508 -AKIDGESTELAISESPQPVEPEAGAPQVIPS------VVIEPASNHEGE-GEHQE-------TA 557

  Fly   455 TATETVTVTQHSVTSTDTDNIVTISDTNTDTDTKTSTGTSQK--GRPVPVVNRHSVNNLNKNPFE 517
            |.||.                   .:...|...:.|.|..|:  ..|.|:.::.:
Mouse   558 TGTEP-------------------REAAEDVAAQGSAGEKQEVATEPTPLDSQAT---------- 593

  Fly   518 DDDERIYEVPADAN-----------TADLPPGVLYRVKATYGYAKEDVDELSFEIGDLIRVIEYD 571
                    :||.|.           |.:||||.||:|:..:.:...:.|||:.:.||::.|:..|
Mouse   594 --------LPASAGAVDASLSAGDATQELPPGFLYKVETLHDFEAANSDELNLQRGDVVLVVPSD 650

  Fly   572 DPEDQEEGWLMGQKEG--------TNEKGLFPANFTR 600
            ...||:.|||:|.||.        ...|||||.||||
Mouse   651 SEADQDAGWLVGVKESDWLQYRDLATYKGLFPENFTR 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	84/211 (40%)
Amph	NP_523717.1	SH3_Amphiphysin	539..602	CDD:212724	27/70 (39%)
Amph	NP_001276475.1	BAR_Amphiphysin_I_II	26..236	CDD:153295	82/209 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..314		23/156 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..445		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..601		40/135 (30%)
		SH3_Amphiphysin_I	618..689	CDD:213016

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834720
Domainoid	1	1.000	188	1.000	Domainoid score	I3307
eggNOG	1	0.900	-	-		E1_KOG3771
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3159
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001177
OrthoInspector	1	1.000	-	-		otm42339
orthoMCL	1	0.900	-	-		OOG6_105748
Panther	1	1.100	-	-	O	PTHR46514
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R565
SonicParanoid	1	1.000	-	-		X1098
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780