Protein Alignment Amph and amph-1

DIOPT Version :9

• Sequence 1: NP_523717.1
• Gene: Amph / 36383
• FlyBaseID: FBgn0027356
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: NP_501711.1
• Gene: amph-1 / 177797
• WormBaseID: WBGene00010272
• Length: 461
• Species: Caenorhabditis elegans
• Alignment Length: 615
• Identity: 167/615 - (27%)
• Similarity: 251/615 - (40%)
• Gaps: 183/615 - (29%)

  Fly    11 KSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIRCVRAAQAASK 75
            |.::|...|.|||:|:.:||...|.||:||.|..|.|:|..|..:|.|:..||...:|...:|.|
 Worm     7 KHLKKATNRTKEKLLEGIGKAKATQDEVFDQHAANLNKQSKSCEKLHKDVKNYSSALRTLLSAEK 71

  Fly    76 TLMDSVCEIYEPQWSG-------YDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPEMKK 133
            .|.|::.:.|||:|..       :|.|..||...|.       .:.|.:...:..|..|||::||
 Worm    72 QLRDTIRDAYEPEWPDREHLTAIFDNLDIQTNELEK-------TVCDDLPQTVTQYVNQFPDLKK 129

  Fly   134 KVEKRNRKLIDYDGQRHSFQNLQANANKRKDDVKLTKGREQLEEARRTYEILNTELHDELPALYD 198
            |:|||.|||:|||..::||.:::| ::|:.:|.||.|...:|:.|.:.|..:|.||.:.|||::|
 Worm   130 KIEKRGRKLVDYDSAKNSFNSVKA-SSKKDNDPKLAKATMELQAAEQMYTEMNNELLEILPAVFD 193

  Fly   199 SRILFLVTNLQTLFATEQVFHNETAKIYSELEAIVDKLATESQRGSNTLRKQTS--NPIKTSSPV 261
            |||.|.|..|||||....|:..:.:|.:.::...:|||. ||.......|.:..  .||.|:|..
 Worm   194 SRITFFVDTLQTLFNANSVYQTDASKFHKQIVMQLDKLG-ESMDYLRVARPEARALTPIDTTSLA 257

  Fly   262 QSPVNKLNNANINSNYQNQITTNGGSSLANSPTSTSSSLQEPRFDSVSSTPEPRP-ESPAAALVS 325
            .|......:.|.:.|          |||..:|:           .||..:|.|.| ..|..::||
 Worm   258 SSDAPATPDQNKSDN----------SSLRQTPS-----------PSVLPSPVPAPMAKPRESVVS 301

  Fly   326 ATPSSPVENGVTTKSLERPELSGLNASAKATTTTQTSPTEDKAVVSEAVKPSETEGAAVAASVTP 390
            ...|                               |:|.:|    .:|....|
 Worm   302 MANS-------------------------------TNPFDD----DDAEHDKE------------ 319

  Fly   391 APPATPAQINGNNNEPSIVKEGGKQPKELPSTTSNAEAAAEAAANNGNSIEEHKQKKLGNDTTVT 455
               |||..:           |...:.|..|...:...||||.|      |...|::|
 Worm   320 ---ATPTDV-----------EEKFEAKVYPKLNAQQTAAAEQA------IAAAKREK-------- 356

  Fly   456 ATETVTVTQHSVTSTDTDNIVTISDTNTDTDTKTSTGTSQKGRPVPVVNRHSVNNLNKNPFEDDD 520
                                            |.::                      |||:|:|
 Worm   357 --------------------------------KEAS----------------------NPFDDED 367

  Fly   521 ERIYEVPADANTADLPP------GV-------LYRVKATYGYAKEDVDELSFEIGDLIRVIEYDD 572
            :...||.......|..|      |:       ||.|.:|:.|...|.||||||.|..|:|||.::
 Worm   368 DESTEVEEAPKKKDPEPTPKPLDGITNEKRKTLYFVTSTHNYKAVDTDELSFEQGVQIKVIEANE 432

  Fly   573 PEDQEEGWLMGQKEGTNEKGLFPANFTRPI 602
            .:..::||.:|:.| ..::|:||.|||:.:
 Worm   433 DDQLDDGWRLGELE-DGKRGVFPENFTKKV 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	80/218 (37%)
		SH3_Amphiphysin	539..602	CDD:212724	27/69 (39%)
amph-1	NP_501711.1	BAR	22..240	CDD:299863	82/226 (36%)
		NPF	252..>390	CDD:293209	47/287 (16%)
		SH3	400..461	CDD:302595	27/61 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158338
Domainoid	1	1.000	161	1.000	Domainoid score	I2448
eggNOG	1	0.900	-	-		E1_KOG3771
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	177	1.000	Inparanoid score	I2689
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1366218at2759
OrthoFinder	1	1.000	-	-		FOG0001177
OrthoInspector	1	1.000	-	-		oto17313
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46514
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R565
SonicParanoid	1	1.000	-	-		X1098
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.930