Protein Alignment Amph and Bin1

DIOPT Version :9

• Sequence 1: NP_523717.1
• Gene: Amph / 36383
• FlyBaseID: FBgn0027356
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: XP_006254558.2
• Gene: Bin1 / 117028
• RGDID: 621786
• Length: 603
• Species: Rattus norvegicus
• Alignment Length: 704
• Identity: 196/704 - (27%)
• Similarity: 295/704 - (41%)
• Gaps: 212/704 - (30%)

  Fly     4 NKGI---MLAKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIR 65
            :||:   .:|.:|||...||:||:||.|||.|.|.||.|:..:.|||:|.....||||:...|:.
  Rat     6 SKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLA 70

  Fly    66 CVRAAQAASKTLMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPE 130
            .|:|...|||.|.:.:.|:|||:|.|.|........::.||.|:..||.||.|:.::||.||||:
  Rat    71 SVKAMHEASKKLSECLQEVYEPEWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPD 135

  Fly   131 MKKKVEKRNRKLIDYDGQRHSFQNLQANANKRKDDVKLTK------------------------- 170
            :|.::.||.|||:|||..||.:::||  ..|:||:.|:.|
  Rat   136 IKSRIAKRGRKLVDYDSARHHYESLQ--TAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQT 198

  Fly   171 ------GREQLEEARRTYEILNTELHDELPALYDSRILFLVTNLQTLFATEQVFHNETAKIYSEL 229
                  ..|:|.:|::.:|.:|.:|.:|||:|::||:.|.|...|::...|:.||.|.:|:...|
  Rat   199 NLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNL 263

  Fly   230 EAIVDKLATESQRGSNTL------RKQTS----------------------NPIKTSSPVQSPVN 266
            ..::  ::.|.|.||||.      ||:|.                      :|....||..:|
  Rat   264 NDVL--VSLEKQHGSNTFTVKAQPRKKTKLFSRLRRKKNSDSAPEKGNKSPSPPPDGSPAATP-- 324

  Fly   267 KLNNANINSNYQNQITTNGGSSLANSPTSTSSSLQEPRFDSVSSTPEPRPESPAAALVS------ 325
                 .|..|::.: ..:|.|..|..|.|.|...:.|      ..|.|...:|:..:..
  Rat   325 -----EIRVNHEPE-PASGASPGATIPKSPSQLRKGP------PVPPPPKHTPSKEMKQEQILSL 377

  Fly   326 -----------ATPS-----SPVENGVTTKSLERPELSGLNASAKATTTTQTS-------PTEDK 367
                       .|||     .|.....:...|:...|..:.:..||.|.:..|       |||.:
  Rat   378 FDDAFVPEISVTTPSQFEAPGPFSEQASLLDLDFEPLPPVASPVKAPTPSGQSIPWDLWEPTESQ 442

  Fly   368 AVVSEAVKPSETEGA-AVA-----ASVTPAPPATPAQINGNNNEPSIVKEGGKQPKELPSTTSNA 426
            |.|..:.:||..||: |||     |...||.||..:::.|...||
  Rat   443 AGVLPSGEPSSAEGSFAVAWPSQTAEPGPAQPAEASEVVGGTQEP-------------------- 487

  Fly   427 EAAAEAAANNGNSIEEHKQKKLGNDTTVTATETVTVTQHSVTSTDTDNIVTISDTNTDTDTKTST 491
               .|.||               ::.|.::...|.|...|.|            .|...:..|:|
  Rat   488 ---GETAA---------------SEATSSSLPAVVVETFSAT------------VNGAVEGSTTT 522

  Fly   492 GTSQKGRPVPVVNRHSVNNLNKNPFEDDDERIYEVPADANTADLPPGVLYRVKATYGYAKEDVDE 556
            |                                       ..|||||.:::|:|.:.|...|.||
  Rat   523 G---------------------------------------RLDLPPGFMFKVQAQHDYTATDTDE 548

  Fly   557 LSFEIGDLIRVIEYDDPEDQEEGWLMGQKEGT-NE-------KGLFPANFTRPI 602
            |..:.||::.||.:.:||:|:||||||.||.. |:       :|:||.|||..:
  Rat   549 LQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERV 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	84/242 (35%)
		SH3_Amphiphysin	539..602	CDD:212724	29/70 (41%)
Bin1	XP_006254558.2	BAR_Amphiphysin_I_II	31..272	CDD:153295	84/244 (34%)
		fibronec_FbpA	<387..>503	CDD:411474	34/153 (22%)
		SH3_Bin1	531..602	CDD:213015	29/70 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338303
Domainoid	1	1.000	186	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E1_KOG3771
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3146
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1366218at2759
OrthoFinder	1	1.000	-	-		FOG0001177
OrthoInspector	1	1.000	-	-		otm44397
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46514
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1098
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860