Protein Alignment Amph and bin2

DIOPT Version :10

• Sequence 1: NP_523717.1
• Gene: Amph / 36383
• FlyBaseID: FBgn0027356
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: XP_002933750.1
• Gene: bin2 / 100486620
• XenbaseID: XB-GENE-983740
• Length: 656
• Species: Xenopus tropicalis
• Alignment Length: 593
• Identity: 166/593 - (27%)
• Similarity: 267/593 - (45%)
• Gaps: 130/593 - (21%)

  Fly    10 AKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIRCVRAAQAAS 74
            ||:|||...||:||:||.||:...|.||:|:.....||:||...|||.|:.......|:|...:|
 Frog    13 AKNVQKRFTRAQEKVLQKLGRTLETKDEMFEQCAYLFNQQQNEGNRLYKDLKAVFSAVKAMHESS 77

  Fly    75 KTLMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPEMKKKVEKRN 139
            |.|.:::..||:|.|.||:.|:......:.||.|:..|:.|||:..::.|..||||.::::.||.
 Frog    78 KRLSETLHVIYKPDWDGYNDLRPIVENDDLLWNDYEEKMSDQVVRIMDNYMAQFPEYRERIAKRG 142

  Fly   140 RKLIDYDGQRHSFQNLQANANKRKDDVKLTKGREQLEEARRTYEILNTELHDELPALYDSRILFL 204
            ||::|||..||..:.|| || |:||:.|:||..|:..:|:..:|.||.||.::||.||.||:...
 Frog   143 RKMVDYDSARHHLEALQ-NA-KKKDEGKITKAEEEFNKAQSIFEDLNKELREDLPVLYSSRVGCY 205

  Fly   205 VTNLQTLFATEQVFHNETAKIYSELEAIVDKLATESQRGSNTLRKQTSNPIKTSSPVQSPVNKLN 269
            ||..:.:.....||:.|.:|:..||..::.|           |.||.||.:.....|:|
 Frog   206 VTIFKNISNLRDVFYKEMSKLNHELYDVMSK-----------LEKQHSNKVFVIKGVKS------ 253

  Fly   270 NANINSNYQNQITTNGGSSLANSPTSTSSSLQEPRFDSVSSTPEPRPESPAAALVSATPSSPVEN 334
                          |..|.:.:||.|:|||     |...|..||           ::|||
 Frog   254 --------------NRKSLVISSPISSSSS-----FFMASIDPE-----------ASTPS----- 283

  Fly   335 GVTTKSLERP-ELSGLNASAKATTTTQTSPTEDKAVVSEAVKPSETEGAAVAASVTPAPPATPAQ 398
             |.|||:.:. |.|.|:::   ::.||.|.:.| ...:::::.|..|              ||.:
 Frog   284 -VNTKSVNQTCENSSLSSN---SSETQDSISMD-GNFTQSLENSSQE--------------TPNE 329

  Fly   399 INGNNNEPSIVKEGGKQPKELPSTTSNAEAAAEAAANNGNSIEEHKQKKLGNDTTVTATETVTVT 463
            ::.:.::.|.:|...:..:|      |..:..:..|.|....::|::            :..|..
 Frog   330 LSQSLSDNSGIKNSNEMEQE------NNMSTMDPMAGNKTDTQKHQE------------DAKTGK 376

  Fly   464 QHSVTSTDTDNIVTISDTNTDTDTKTSTGTSQKGRPVPVVNRHSVNNLNKNPFEDDDERIYEVPA 528
            ....|.....||  |.:.:...|..:|..:||||          :..|.|...|..||     .:
 Frog   377 SEEETQAGPYNI--IQERSGAIDQNSSAFSSQKG----------LGELMKRNLEASDE-----VS 424

  Fly   529 DANTADLPPGVLYRVKATYGYAKEDVDELSFEIGDL--------IRVIEYDDPEDQEEGWLM--G 583
            |..|..|.       :...|...:::|:   |:.|.        .:|...|:..|:::.:|.  |
 Frog   425 DGTTICLS-------RDQNGDTNKEIDK---ELNDAKPRELCQKAQVDSQDETHDKKQEFLSTNG 479

  Fly   584 QKEGTNEK 591
            .|: |.||
 Frog   480 LKD-TKEK 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	80/211 (38%)
		PTZ00449	<275..>396	CDD:185628	28/121 (23%)
		SH3_Amphiphysin	539..602	CDD:212724	13/63 (21%)
bin2	XP_002933750.1	BAR	29..239	CDD:472257	81/222 (36%)