Protein Alignment Amph and amph

DIOPT Version :10

• Sequence 1: NP_523717.1
• Gene: Amph / 36383
• FlyBaseID: FBgn0027356
• Length: 602
• Species: Drosophila melanogaster
• Sequence 2: XP_031759042.1
• Gene: amph / 100125136
• XenbaseID: XB-GENE-993128
• Length: 937
• Species: Xenopus tropicalis
• Alignment Length: 681
• Identity: 180/681 - (26%)
• Similarity: 284/681 - (41%)
• Gaps: 168/681 - (24%)

  Fly     1 MTENKGIMLAKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIR 65
            |.:.|..:.||:|||...||:||:||.|||.|.|.||.|::::.||.||:|..:|||:|...|:.
 Frog     1 MADMKTGIFAKNVQKRLSRAQEKVLQKLGKADETKDEQFEEYVQNFKRQEAEGSRLQREMRAYLT 65

  Fly    66 CVRAAQAASKTLMDSVCEIYEPQWSGYDALQAQTGASESLWADFAHKLGDQVLIPLNTYTGQFPE 130
            .::..|.||..|.:|:.|:|||.|.|.|.::......::||.||..||.|..||.|:||.||||:
 Frog    66 AIKGMQEASMKLTESLHEVYEPDWYGRDDVKMVGEKCDTLWEDFHQKLVDGALITLDTYLGQFPD 130

  Fly   131 MKKKVEKRNRKLIDYDGQRHSFQNLQANANKRKDDVKLTKGREQLEEARRTYEILNTELHDELPA 195
            :|.::.||:|||:|||..||..::|| || ||||:.:::|..|:.::|::.:|..|.:|.:|||:
 Frog   131 IKNRIAKRSRKLVDYDSARHHLESLQ-NA-KRKDEGRISKAEEEFQKAQKVFEDFNIDLQEELPS 193

  Fly   196 LYDSRILFLVTNLQTLFATEQVFHNETAKIYSELEAIVDKLATESQRGSNTLR--KQTSNPI--- 255
            |:..||.|.|...|.:...|..||.|...:..:|..::.||..:....:.|::  ...|.|:
 Frog   194 LWSRRIGFYVNTFQNISGLEAKFHKEITVLCHKLYEVMTKLGEQHADKAFTIQGAPSDSGPLRIA 258

  Fly   256 KTSSPVQSPVNKLNNANINSNYQNQITTNGGSSLANSPTSTSSSLQEPRFDSVSSTPEP-RPESP 319
            ||.||.:.                  .....|.|| ||..|.:.:         |:|.| ||:||
 Frog   259 KTPSPPEE------------------VPEEPSPLA-SPNHTLAPI---------SSPAPARPKSP 295

  Fly   320 AAALVSATPSSPVENGVTTKSLER------------PELSGLNASAKATTTTQTSPTEDKAVVS- 371
             :.|....|..|:.....:|.|::            ||::       .||.:|....|:|...|
 Frog   296 -SQLRKGPPVPPLPKLTPSKELQQENIISFFEDNFVPEIN-------VTTPSQNEAVEEKKEESL 352

  Fly   372 -----EAVKPSETEGAAVAASVTPAPPATP----------AQINGNNNEPSIVKE---------- 411
                 :..|| |:....:..|.:|.....|          .|.|....:|.:.:.
 Frog   353 LDLDFDPFKP-ESATVGIVQSHSPLSQTLPWDLWTCFCPSTQTNNEVVQPPVSESLSLCNLIMAE 416

  Fly   412 ----GG------KQPKELPST------------TSNAEAAAEAAANN-------GNSIEEHKQKK 447
                |.      .||.|:..:            |.|..|.||.:.:|       ....|||...:
 Frog   417 TPSCGSAEDLNISQPHEVADSWGLENSTVRDRVTPNETAQAEDSQDNLHGENAHSKCAEEHYSLE 481

  Fly   448 LGNDTT--------------VTATETVTVTQHSVTSTDTDNIVTISDTN-----TDTDTKTSTGT 493
            ...|..              |:.::|:.:..:|:.:...|...|:....     .|.:....|..
 Frog   482 SNLDRNESFEDREVHKFLPEVSISDTINIVDNSLQTEILDKEETLDGARKHVFIVDLELYEQTEP 546

  Fly   494 SQKGRPVPVVNRHSVNNLNKNPFEDDDERIYEVPADANTADLPPGVLYRVKATYGYAKEDVDELS 558
            |              :|: ||.||::.|..     ..|...|                .:.:.|.
 Frog   547 S--------------SNI-KNNFEEECEEY-----SPNNDQL----------------NETESLQ 575

  Fly   559 FEIGDLIRVIEYDDPEDQEEGWLMGQKEGTN 589
            ....:.:...|.:...|||: .|:.:|..|:
 Frog   576 LSTKEYLETTEVEFALDQEQ-VLVNKKSETD 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amph	NP_523717.1	BAR_Amphiphysin	26..238	CDD:153272	88/211 (42%)
		PTZ00449	<275..>396	CDD:185628	31/139 (22%)
		SH3_Amphiphysin	539..602	CDD:212724	8/51 (16%)
amph	XP_031759042.1	BAR_Amphiphysin_I_II	26..236	CDD:153295	88/211 (42%)
		PHA02682	<283..>358	CDD:177464	20/91 (22%)