DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sin3A and SIN3

DIOPT Version :9

Sequence 1:	NP_001246282.1	Gene:	Sin3A / 36382	FlyBaseID:	FBgn0022764	Length:	2066	Species:	Drosophila melanogaster
Sequence 2:	NP_014639.1	Gene:	SIN3 / 854158	SGDID:	S000005364	Length:	1536	Species:	Saccharomyces cerevisiae

Alignment Length:	2050	Identity:	483/2050 - (23%)
Similarity:	741/2050 - (36%)	Gaps:	730/2050 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QAGGTLKANTADGAN-------TVQIHVTGGGAANNPASAQ-----TVSSSSQTGTIRQ--RTIS 210
            |:.....:|.|.|:|       ::|        .|.|...|     |:.|.|...|..:  |..:
Yeast    11 QSNDVATSNDATGSNERNEKEPSLQ--------GNKPGFVQQQQRITLPSLSALSTKEEDRRDSN 67

  Fly   211 GTQTV--------------ATAVGNLATISQ-QQPVQQSPLGKAQTPPSSVVA------------ 248
            |.|.:              :.|:.::||.|. :||.:..|..|:.:...|:.|
Yeast    68 GQQALTSHAAHILGYPPPHSNAMPSIATDSALKQPHEYHPRPKSSSSSPSINASLMNAGPAPLPT 132

  Fly   249 ------------NSIPVGG---TTPPQGQSG-----NATPR------------------------ 269
                        |.:|:..   |..|:..:|     .||.|
Yeast   133 VGAASFSLSRFDNPLPIKAPVHTEEPKSYNGLQEEEKATQRPQDCKEVPAGVQPADAPDPSSNHA 197

  Fly   270 ---------------------LKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGV 313
                                 |.|:||||||:|||:|::.:|.|||.||||||:|||..||||||
Yeast   198 DANDDNNNNENSHDEDADYRPLNVKDALSYLEQVKFQFSSRPDIYNLFLDIMKDFKSQAIDTPGV 262

  Fly   314 IERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPP---GAPTSTGTVHMLTG 375
            ||||||||:|:..||.|||.|||.||:||       ||    |.|..|   ..|..|.||:   .
Yeast   263 IERVSTLFRGYPILIQGFNTFLPQGYRIE-------CS----SNPDDPIRVTTPMGTTTVN---N 313

  Fly   376 NSSMSGAGHIAIKTTNAATL--TPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQ 438
            |.|.||.|     ||:|..|  .|.:........:.|..:.|                 :::..:
Yeast   314 NISPSGRG-----TTDAQELGSFPESDGNGVQQPSNVPMVPS-----------------SVYQSE 356

  Fly   439 QATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAH-NVPQNYSRDRERATITPTGQVAGA 502
            |....|...|      :..|:|...:...|..|     || .:||:
Yeast   357 QNQDQQQSLP------LLATSSGLPSIQQPEMP-----AHRQIPQS------------------- 391

  Fly   503 AANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPV 567
                                                              ||::..|..::|..|
Yeast   392 --------------------------------------------------QSLVPQEDAKKNVDV 406

  Fly   568 EFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFG 632
            ||:.||:||||||.||.:||..||.|||||..||||||.:             .|||.||..||.
Yeast   407 EFSQAISYVNKIKTRFADQPDIYKHFLEILQTYQREQKPI-------------NEVYAQVTHLFQ 458

  Fly   633 QDEDLLREFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHL 697
            ...|||.:|.:||||:         |.||:....|.::
Yeast   459 NAPDLLEDFKKFLPDS---------SASANQQVQHAQQ--------------------------- 487

  Fly   698 GATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQ 762
                        ||                       ||.|               |...||..|
Yeast   488 ------------HA-----------------------QQQH---------------EAQMHAQAQ 502

  Fly   763 QQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRN-NHHVQKYVGH-----APNQN 821
            .||.                           |...|...|:.:. .:....|.||     .|.||
Yeast   503 AQAQ---------------------------AQAQVEQQKQQQQFLYPASGYYGHPSNRGIPQQN 540

  Fly   822 L---------THG---HNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPL--------- 865
            |         |:|   |.|.:...:..|.....:|.|..:..:....||:...|||
Yeast   541 LPPIGSFSPPTNGSTVHEAYQDQQHMQPPHFMPLPSIVQHGPNMVHQGIANENPPLSDLRTSLTE 605

  Fly   866 ---PSG-----PHGQHNSGSATRRPG----------DDSLVGHYASGAPPAKRP-KPYCRDVSFS 911
               ||.     .|.|..|..|..:.|          |.|:|       |....| :|...::|.:
Yeast   606 QYAPSSIQHQQQHPQSISPIANTQYGDIPVRPEIDLDPSIV-------PVVPEPTEPIENNISLN 663

  Fly   912 EASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWF 976
            |        :..||:|.::.:.:..:|..||:.|.|::|:|:...:|:..|..:|....:|..||
Yeast   664 E--------EVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGSNKELFTWF 720

  Fly   977 TDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYC 1041
            .:|:|                  .|.:.....|..|::   |:        :||..|:..|.||.
Yeast   721 KNFVG------------------YQEKTKCIENIVHEK---HR--------LDLDLCEAFGPSYK 756

  Fly  1042 ALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRNIHRTEDERFEL 1106
            .||:|.....||||..:|.|||||:||..|.||||||.|:..||.|:|||::    :.|:||.|.
Yeast   757 RLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASEDSGFIAHRKNQYEETLF----KIEEERHEY 817

  Fly  1107 DLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSG-EIITG 1170
            |..||.|..||:.||.:..|:..|:..|.:.|.|...||.||.||:::.|.::|..:.| |||..
Yeast   818 DFYIESNLRTIQCLETIVNKIENMTENEKANFKLPPGLGHTSMTIYKKVIRKVYDKERGFEIIDA 882

  Fly  1171 MKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKS 1235
            :.::|.|..|:||||||.|:||||.||:.:||.|||..:|.:.|||||..:.||..|.|.|.:|.
Yeast   883 LHEHPAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGLTFKQADKKLLTTKQ 947

  Fly  1236 LFNEIETLYDERHDQEDDAMEPFGP----HLVLPYKDKTILDDAANLLIHHVKRQTGIQKQEKQK 1296
            |.:||.::   :.||.:..:....|    .|...:.||.|..|...|....:...|.....:|::
Yeast   948 LISEISSI---KVDQTNKKIHWLTPKPKSQLDFDFPDKNIFYDILCLADTFITHTTAYSNPDKER 1009

  Fly  1297 IKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTKMDVDSPLGRTESSTRNAKSTPSESASP 1361
            :|.:::.|: .|||:    :|.::.:::.     .:.|.:|....|..:.|:..::..|.:....
Yeast  1010 LKDLLKYFI-SLFFS----ISFEKIEESL-----YSHKQNVSESSGSDDGSSIASRKRPYQQEMS 1064

  Fly  1362 ARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASAASSSTV 1426
            .......|....  :|:..|:                      |...|..|.
Yeast  1065 LLDILHRSRYQK--LKRSNDE----------------------DGKVPQLSE------------- 1092

  Fly  1427 SGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKL---LPP 1488
                 .|:::|.:..:||                      .:|.|.|        ||.|   |..
Yeast  1093 -----PPEEEPNTIEEEE----------------------LIDEEAK--------NPWLTGNLVE 1122

  Fly  1489 HAHGQREDESYTLF--FANNNWYLFLRLHAILCDRLH--VMYERARLLAIEEERCRVNRRESTAT 1549
            .|:.|...::.::|  |||.|.|:|.|         |  .:||  |||.|::...||.:..:|.:
Yeast  1123 EANSQGIIQNRSIFNLFANTNIYIFFR---------HWTTIYE--RLLEIKQMNERVTKEINTRS 1176

  Fly  1550 ALRLKPKPEI---QV---------EDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFT 1602
            .:......::   |:         ||.|...|.:.:.:::|:::...||:::|:.:...|:..:|
Yeast  1177 TVTFAKDLDLLSSQLSEMGLDFVGEDAYKQVLRLSRRLINGDLEHQWFEESLRQAYNNKAFKLYT 1241

  Fly  1603 LDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAES-ILNE 1666
            :|||..:.|:.....:|:....:.:.||..::....|.  .:|       ::.|:.:..| :.|.
Yeast  1242 IDKVTQSLVKHAHTLMTDAKTAEIMALFVKDRNASTTS--AKD-------QIIYRLQVRSHMSNT 1297

  Fly  1667 ENCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYV--------------ERLANPALG 1717
            ||.|::...|....|:|:.:..:...:.:|.| ...|:..||              |:|..|.|
Yeast  1298 ENMFRIEFDKRTLHVSIQYIALDDLTLKEPKA-DEDKWKYYVTSYALPHPTEGIPHEKLKIPFL- 1360

  Fly  1718 GGGNTGRSDSALGNDSVVD-GSDIK-TEADEDTAELRYREGGIGGAGKARFLVRNKRRSKLLEEQ 1780
                          :.::: |.||. ||.||:.:.    ||
Yeast  1361 --------------ERLIEFGQDIDGTEVDEEFSP----EG------------------------ 1383

  Fly  1781 VRQLFEHRRNRIEQHGTAASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGKRLERLG 1845
                       |........::||:....|.:.|........||......|:|.
Yeast  1384 -----------ISVSTLKIKIQPITYQLHIENGSYDVFTRKATNKYPTIANDNT----------- 1426

  Fly  1846 APQVGLAEQYAFNDRDEISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHFQTYVN 1910
              |.|:..|     :.|:.:...:  |.|..:|                 .:.:|:....|   .
Yeast  1427 --QKGMVSQ-----KKELISKFLD--CAVGLRN-----------------NLDEAQKLSMQ---K 1462

  Fly  1911 KWLQQHVSEQQQQNCVDWLLGKTADQINASGWGSASKTKTVQQKDTSKTPYRIYNRYRVVQSAVS 1975
            ||          :|..|                |.:||....|...|:|     .:.::.:...|
Yeast  1463 KW----------ENLKD----------------SIAKTSAGNQGIESET-----EKGKITKQEQS 1496

  Fly  1976 GGLMSATAPTPDGSVPAVNSAPSGSVSTVNNVQGS 2010
            ..|.|:||.....|:..|  ....::.|..|.:.|
Yeast  1497 DNLDSSTASVLPASITTV--PQDDNIETTGNTESS 1529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	413/1648 (25%)
		PAH	291..335	CDD:280780	32/43 (74%)
		PAH	588..645	CDD:280780	24/56 (43%)
		PAH	936..980	CDD:280780	13/43 (30%)
		Sin3_corepress	1034..1133	CDD:285494	46/98 (47%)
		Sin3a_C	1502..>1710	CDD:293484	52/238 (22%)
SIN3	NP_014639.1	Sin3a_C	1138..1410	CDD:293484	69/346 (20%)
		Sin3	75..1493	CDD:227889	457/1938 (24%)
		PAH	240..284	CDD:280780	32/43 (74%)
		PAH	427..471	CDD:280780	24/56 (43%)
		PAH	682..724	CDD:280780	13/41 (32%)
		Sin3_corepress	749..844	CDD:285494	46/98 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346237
Domainoid	1	1.000	92	1.000	Domainoid score	I1711
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4104
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		oto100224
orthoMCL	1	0.900	-	-		OOG6_101145
Panther	1	1.100	-	-	LDO	PTHR12346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1023
SonicParanoid	1	1.000	-	-		X631
TreeFam	1	0.960	-	-
	13	12.680