DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sin3A and SNL2

DIOPT Version :9

Sequence 1:	NP_001246282.1	Gene:	Sin3A / 36382	FlyBaseID:	FBgn0022764	Length:	2066	Species:	Drosophila melanogaster
Sequence 2:	NP_197006.2	Gene:	SNL2 / 831354	AraportID:	AT5G15020	Length:	1367	Species:	Arabidopsis thaliana

Alignment Length:	1798	Identity:	392/1798 - (21%)
Similarity:	623/1798 - (34%)	Gaps:	682/1798 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 PLGKAQTPPSSVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDI 299
            |||.::  ..|...:.|..||:.   |:.|..|.:|..:|||:||.:||..:.||...|:.||::
plant    18 PLGSSR--GESYEQSPITGGGSI---GEGGINTQKLTTDDALTYLKEVKEMFQDQRDKYDMFLEV 77

  Fly   300 MKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAP 364
            ||:||:...||.|||.||..|||||..||:|||.|||.|::|.:..         |..||
plant    78 MKDFKAQKTDTSGVISRVKELFKGHNNLIFGFNTFLPKGFEITLDD---------VEAPS----- 128

  Fly   365 TSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASL 429

plant   129 ----------------------------------------------------------------- 128

  Fly   430 TQTTIHALQQATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATIT 494

plant   129 ----------------------------------------------------------------- 128

  Fly   495 PTGQVAGAAANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGE 559

plant   129 ----------------------------------------------------------------- 128

  Fly   560 TGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVY 624
                .:.|||..||::|||||.|||:....||.|||||:.|:::.|.:             .|||
plant   129 ----KKTVEFEEAISFVNKIKTRFQHNELVYKSFLEILNMYRKDNKDI-------------TEVY 176

  Fly   625 TQVAKLFGQDEDLLREFGQFLPDA-TNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASP 688
            .:|:.||....|||.||.:||||: ..|...|.:...|..::|.|
plant   177 NEVSTLFEDHSDLLEEFTRFLPDSLAPHTEAQLLRSQAQRYDDRG-------------------- 221

  Fly   689 APSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILF 753
              ||.||                  :..:.........:|..:...:.:.|..|.||..::.:..
plant   222 --SGPPL------------------VRRMFMEKDRRRERTVASRGDRDHSVDRSDLNDDKSMVKM 266

  Fly   754 EKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAP 818
            .:|....:                                       ||::|.........|.|.
plant   267 HRDQRKRV---------------------------------------DKDNRERRSRDLEDGEAE 292

  Fly   819 NQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPG 883
            ..||.|....:||                                               :||
plant   293 QDNLQHFSEKRKS-----------------------------------------------SRR-- 308

  Fly   884 DDSLVGHYASGAPPAKRPKPYCRDVSFSEASSKCTISDAAFF--DKVRKALRSPEVYDNFLRCLT 946
               :.|..|...|           .|.||.::..::.:.||.  :||::.|.|.:.|..||:||.
plant   309 ---MEGFEAYSGP-----------ASHSEKNNLKSMYNQAFLFCEKVKERLCSQDDYQAFLKCLN 359

  Fly   947 LFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFL----GPPSGQPAGGLIDGMPLAATQRQG--- 1004
            :|:..|:.:.:|..|||..|.|||||:..|..|.    .....|...|::....|.:.:...
plant   360 MFSNGIIQRKDLQNLVSDVLGKFPDLMDEFNQFFERCESIDGFQHLAGVMSKKSLGSEENLSRSV 424

  Fly  1005 -GGSSNSSHDRGT-----SHQSAAEY----VQDVDLSSCKRLGASYCALPQS-TVP----KKCSG 1054
             |...:..|.|..     ..:|..:|    :|::|||.|:|...||..||.. .:|    ::.||
plant   425 KGEEKDREHKRDVEAAKEKERSKDKYMGKSIQELDLSDCERCTPSYRLLPPDYPIPSVRHRQKSG 489

  Fly  1055 RTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEVNSATIRV 1119
            ..     ||||.|||. |..|||.:|...|:.|:||:::    |.||:|||||:::|...:..:.
plant   490 AA-----VLNDHWVSV-TSGSEDYSFKHMRRNQYEESLF----RCEDDRFELDMLLESVGSAAKS 544

  Fly  1120 LENL-----QKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAV 1179
            .|.|     .||:|...:     |.::||.    ..::.|.|.|:|||...::...::|||..|:
plant   545 AEELLNIIIDKKISFEGS-----FRIEDHF----TALNLRCIERLYGDHGLDVTDLIRKNPAAAL 600

  Fly  1180 PIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLY 1244
            |::|.|||.|::||.:.::.||..|.:...|.:.|||||::..||..|.|.|.:|:|.:|::.|
plant   601 PVILTRLKQKQDEWTKCREGFNVVWADVYAKNHYKSLDHRSFYFKQQDSKNLSAKALVSEVKDL- 664

  Fly  1245 DERHDQEDDAM--------EPFGPHLVLPYKDKTILDDAANLL------IHHVKRQTG------- 1288
            .|:..:|||.:        :|..|||...|.|:.|.:|...|:      |...|.|||
plant   665 KEKSQKEDDVVLSISAGYRQPIIPHLEYDYLDRAIHEDLFKLVQFSCEEICSTKEQTGKVLKLWA 729

  Fly  1289 ----------------------IQKQEKQ------------KIKQIIRQFV-------------- 1305
                                  ::.|.::            .|..:.||..
plant   730 NFLELMLDVAPRAKGSDSVEDVVETQHQRAFTSGEANESSDAISLVSRQLKFATNGDVHASSGVS 794

  Fly  1306 -------------------------PDLFFAPRQPLSD--------------DER----DDAFPF 1327
                                     .|:.....:|..|              |||    ..:||.
plant   795 KHGETGLLNRDSSGKENLKDGDLANKDVATCAEKPQKDQEIGNGAAKRSGDVDERVATSSSSFPS 859

  Fly  1328 LVDDNT-----------------------KMD-------VDSPLGR-------TESSTRNAKSTP 1355
            .|::|.                       |:|       ||  :||       .:|.|..|.|..
plant   860 GVENNNGKVGSRDSSGSRGILSKPSEAIDKVDSIQHTQGVD--IGRIIVLGNGLQSDTSKANSNY 922

  Fly  1356 SESASPARSNASTSSVTPAG------IKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSA 1414
            .||..|::.......::|.|      :..|..:.|||    |....:..:.....:||.......
plant   923 DESGGPSKIEKEEGELSPVGDSEDNFVVYEDRELKAT----AKTEHSVEAEGENDEDADDEDGDD 983

  Fly  1415 AAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVD---VEIKLEH 1476
            |:.|...:|.|.|..:...:||  :..:|||......|.|.|..:|:     |::   :|.|...
plant   984 ASEAGEDASGTESIGDECSQDD--NGVEEEGEHDEIDGKAESEGEAE-----GMESHLIEDKGLF 1041

  Fly  1477 PAD---FSNPKLLPPH----AHGQREDESYTLFFANNNWYLFLRLHAILC----DRL-HVMYERA 1529
            |:.   ..:.|.|..|    |....:.:...:|:.|:::|:..|||.:..    |.| |::|||
plant  1042 PSSERVLLSVKPLSKHIAAAALVDEKKKDSRVFYGNDDFYVLFRLHRVSAIDSYDLLSHILYER- 1105

  Fly  1530 RLLAIEEERCRVNRRESTATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFG 1594
              :...:..|       :.:.::|:...:....|.|..|::.|.::|:|:.:::.|||..|.:.|
plant  1106 --ILSAKTYC-------SGSEMKLRNTKDTCSPDPYARFMNALFSLLNGSAENSKFEDECRAIIG 1161

  Fly  1595 IYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRK 1659
            ..:|:.|||:|::...|:|||..|.:......::|:..|.        .|...:.||  ..|...
plant  1162 NQSYVLFTLEKLIYKLVKQLQAVVADDMDNKLLQLYEYEN--------SRRPGRVFD--SVYYEN 1216

  Fly  1660 AESILNEENCFKVYIYKIDC-----RVTIELLDSEPEEVDKPAALKAQKFSKYV--ERLANPALG 1717
            |..:|:|||     ||:::|     |::|:|:|:..|:.|..|......|:.|:  |.|:|   .
plant  1217 ARILLHEEN-----IYRLECSSSPSRLSIQLMDNIIEKPDAYAVSMEPTFTSYLQNEFLSN---S 1273

  Fly  1718 GG--------------GNTGRSD-----SALGNDSVVDGSDIKTEADE-------DTAELRYREG 1756
            .|              |..|..|     .|:....|::|.:.|.....       ||.:
plant  1274 SGKKELQDIVLQRNMRGYNGLDDLAVACKAMEGVQVINGLECKMSCSSYKISYVLDTED------ 1332

  Fly  1757 GIGGAGKARFLVRNKRRSKLLEEQVRQLFEHRRNRIEQHGTAA 1799
                     |..|.|::.|.....:.:|.::|..|..:..:|:
plant  1333 ---------FFHRKKKQKKSNNLSLAKLSQNRIARFHKFLSAS 1366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	371/1687 (22%)
		PAH	291..335	CDD:280780	24/43 (56%)
		PAH	588..645	CDD:280780	20/56 (36%)
		PAH	936..980	CDD:280780	18/43 (42%)
		Sin3_corepress	1034..1133	CDD:285494	38/108 (35%)
		Sin3a_C	1502..>1710	CDD:293484	58/219 (26%)
SNL2	NP_197006.2	PAH	69..113	CDD:280780	24/43 (56%)
		PAH	154..197	CDD:280780	20/55 (36%)
		PAH	349..393	CDD:280780	18/43 (42%)
		HDAC_interact	462..558	CDD:214808	38/105 (36%)
		PHA03169	788..>1031	CDD:223003	47/255 (18%)
		Sin3a_C	1074..1334	CDD:293484	71/302 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2056
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I567
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253485at2759
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		otm2965
orthoMCL	1	0.900	-	-		OOG6_101145
Panther	1	1.100	-	-	O	PTHR12346
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830