Protein Alignment Sin3A and WRKY19

DIOPT Version :10

• Sequence 1: NP_001246282.1
• Gene: Sin3A / 36382
• FlyBaseID: FBgn0022764
• Length: 2066
• Species: Drosophila melanogaster
• Sequence 2: NP_001118968.1
• Gene: WRKY19 / 826810
• AraportID: AT4G12020
• Length: 1895
• Species: Arabidopsis thaliana
• Alignment Length: 2178
• Identity: 390/2178 - (17%)
• Similarity: 629/2178 - (28%)
• Gaps: 871/2178 - (39%)

  Fly    82 HGGAQTIAYLPSTTPTATNLKTTTSIVDSTTAGGPVGAGAQVAVGVG----------SAAG---- 132
            |||.:...||                  ..|.|........:|.|.|          ||.|
plant   137 HGGGRRCEYL------------------GCTKGAEGSTDFCIAHGGGRRCNHEDCTRSAWGRTEF 183

  Fly   133 ----GGGVVVST---GSTGTQTLQYTTSYSVASIQAGGTLKANTADGANTVQ-------IHVTGG 183
                |||....|   |.:.:..|.:..::       ||..|.:..|.....:       :|  ||
plant   184 CVKHGGGARCKTYGCGKSASGPLPFCRAH-------GGGKKCSHEDCTGFARGRSGLCLMH--GG 239

  Fly   184 G----AANNPASAQTVSS--SSQTGTIRQRTISGTQTVATAVGNLATISQQQPVQQSPLGKAQTP 242
            |    ..|...||:.:|.  .|..|..|.::|..|                    :...|.....
plant   240 GKRCQRENCTKSAEGLSGLCISHGGGRRCQSIGCT--------------------KGAKGSKMFC 284

  Fly   243 PSSVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHC 307
            .:.:....:.:.|    .|..|..|    ..|||:||..||.::.|..: |:.||:::.:.|...
plant   285 KACITKRPLTIDG----GGNMGGVT----TGDALNYLKAVKDKFEDSEK-YDTFLEVLNDCKHQG 340

  Fly   308 IDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHM 372
            :||.|||.|:..|||||.:|:.|||.:|...|:|.|        :|....|
plant   341 VDTSGVIARLKDLFKGHDDLLLGFNTYLSKEYQITI--------LPEDDFP-------------- 383

  Fly   373 LTGNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHAL 437
                                                 :..:........||:..|...|...:
plant   384 -------------------------------------IDFLDKVEGPYEMTYQQAQTVQANAN-- 409

  Fly   438 QQATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGA 502
               ..||::.|          :|:|..:...|||.|..||.:                    :..
plant   410 ---MQPQTEYP----------SSSAVQSFSSGQPQIPTSAPD--------------------SSL 441

  Fly   503 AANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPV 567
            .|..|.|...::             .|          .:|..|:..:|.:......:.||:
plant   442 LAKSNTSGITII-------------EH----------MSQQPLNVDKQVNDGYNWQKYGQK---- 479

  Fly   568 EFNHAITYVNKIK-NRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLF 631
                      |:| ::|   |..|.|...:             |..::.|:  |:.:..|||::.
plant   480 ----------KVKGSKF---PLSYYKCTYL-------------GCPSKRKV--ERSLDGQVAEIV 516

  Fly   632 GQDEDLLREFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLH 696
            .:|..             ||:.           .:.||..:.|...|:...::..|...:.|...
plant   517 YKDRH-------------NHEP-----------PNQGKDGSTTYLSGSSTHINCMSSELTASQFS 557

  Fly   697 LGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGL 761
            ...|.:.|.:.::.|..|..:|..         ::|::..|.....|          |||..
plant   558 SNKTKIEQQEAASLATTIEYMSEA---------SDNEEDSNGETSEG----------EKDED--- 600

  Fly   762 QQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGH 826
            :.:..:|...|....  ...|:...:..|.|........|                   ||..|:
plant   601 EPEPKRRITEVQVSE--LADASDRTVREPRVIFQTTSEVD-------------------NLDDGY 644

  Fly   827 NAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHY 891
            ..:|   ||...|.|:                          |:.:.:|..      |..:|..|
plant   645 RWRK---YGQKVVKGN--------------------------PYPRFSSSK------DYDVVIRY 674

  Fly   892 ASGAPPAKRPKPYCRDVSFSEASSKCTISDAAFFDKVRKAL--RSPEVYDNF--------LRCLT 946
                                   .:..||:..|...:|.:|  |...||:.|        .|.|.
plant   675 -----------------------GRADISNEDFISHLRASLCRRGISVYEKFNEVDALPKCRVLI 716

  Fly   947 LFNQEIVSKTELLGL-----------------VSPFLMKFPDLLRWFTDFL-------------G 981
            :........:.||.:                 :||:            ||:             .
plant   717 IVLTSTYVPSNLLNILEHQHTEDRVVYPIFYRLSPY------------DFVCNSKNYERFYLQDE 769

  Fly   982 PPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQS 1046
            |...|.|...|..||         |.:       .:.:|.:|.:.::...:.|.|
plant   770 PKKWQAALKEITQMP---------GYT-------LTDKSESELIDEIVRDALKVL---------- 808

  Fly  1047 TVPKKCSG---------------RTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRNI 1096
                 ||.               .:.||.|.|:.:  |...|.:     |...||...|.|:|.|
plant   809 -----CSADKVNMIGMDMQVEEILSLLCIESLDVR--SIGIWGT-----VGIGKTTIAEEIFRKI 861

  Fly  1097 ---------------------HRTEDERFELDLVIEVNSATIRVLE--------NLQKKMSRMST 1132
                                 |....|.| |..|:||....||:.:        .||:|...:..
plant   862 SVQYETCVVLKDLHKEVEVKGHDAVRENF-LSEVLEVEPHVIRISDIKTSFLRSRLQRKRILVIL 925

  Fly  1133 EELSKFH-LDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAV----------------- 1179
            ::::.:. :|..||    |::      .:|..|..|:|...:..||..
plant   926 DDVNDYRDVDTFLG----TLN------YFGPGSRIIMTSRNRRVFVLCKIDHVYEVKPLDIPKSL 980

  Fly  1180 -------------PIVLKRLKVKEEEWREAQ-------KTFNKQWREQNEK------YYLKSL-D 1217
                         |.|.|.|.::..::....       .:.:::|.:.:::      .|:..: :
plant   981 LLLDRGTCQIVLSPEVYKTLSLELVKFSNGNPQVLQFLSSIDREWNKLSQEVKTTSPIYIPGIFE 1045

  Fly  1218 HQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAME----PFGPH-----LVLPYKDKTILD 1273
            ........|:      :.:|.:|...:: |.|:::.||.    .|..|     ||    ||::|.
plant  1046 KSCCGLDDNE------RGIFLDIACFFN-RIDKDNVAMLLDGCGFSAHVGFRGLV----DKSLLT 1099

  Fly  1274 DAANLLIHHVK--RQTGIQKQEKQKIKQIIRQFVPD-------LFFAP--RQPLSDDERDDAFP- 1326
            .:.:.|:..:.  :.||         ::|:||...|       |:.|.  |....:|....|..
plant  1100 ISQHNLVDMLSFIQATG---------REIVRQESADRPGDRSRLWNADYIRHVFINDTGTSAIEG 1155

  Fly  1327 -FLVDDNTKMDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSF 1390
             ||...|.|.|.:..:.....:.|..|.    ..|.|......|  .|.|::......:.....:
plant  1156 IFLDMLNLKFDANPNVFEKMCNLRLLKL----YCSKAEEKHGVS--FPQGLEYLPSKLRLLHWEY 1214

  Fly  1391 APASSATASSATPVDDATPSTSSAAA----AASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSS 1451
            .|.|| ...|..|.:....:..|:.|    ....|...|.:.:..|.|...|         |.|.
plant  1215 YPLSS-LPKSFNPENLVELNLPSSCAKKLWKGKKARFCTTNSSLEKLKKMRL---------SYSD 1269

  Fly  1452 GVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYL----FL 1512
            .:...||.:..|         .||| .|......|              |..:.:..||    ||
plant  1270 QLTKIPRLSSAT---------NLEH-IDLEGCNSL--------------LSLSQSISYLKKLVFL 1310

  Fly  1513 RLHAILCDRLH---VMYERARLLAIEEERCRVNRRESTATALRLKPKPEI--QVEDYY------- 1565
            .|..  |.:|.   .|.:...|..:....|.           :|...|||  .|::.|
plant  1311 NLKG--CSKLENIPSMVDLESLEVLNLSGCS-----------KLGNFPEISPNVKELYMGGTMIQ 1362

  Fly  1566 --------------------------PTFLDMLKNV----LDGNMDSNTFEDTMREMFGIYAYIS 1600
                                      ||.:..||::    |.|.:....|.|:.|.|    ..:.
plant  1363 EIPSSIKNLVLLEKLDLENSRHLKNLPTSIYKLKHLETLNLSGCISLERFPDSSRRM----KCLR 1423

  Fly  1601 FTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILN 1665
            | || :....:::|...::...|||  ||...:.||........:|:.|
plant  1424 F-LD-LSRTDIKELPSSISYLTALD--ELLFVDSRRNSPVVTNPNANST---------------- 1468

  Fly  1666 EENCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALG 1730
                              ||:.||               |..:|.|..||              .
plant  1469 ------------------ELMPSE---------------SSKLEILGTPA--------------D 1486

  Fly  1731 NDSVVDGSDIKTEADEDTAEL--RYRE-------GGIGGAGKARFLVRNKRRSKLLEEQVRQLFE 1786
            |:.||.|:..||...|.|..:  :.||       ..:||..|.       .|..:|:.|......
plant  1487 NEVVVGGTVEKTRGIERTPTILVKSREYLIPDDVVAVGGDIKG-------LRPPVLQLQPAMKLS 1544

  Fly  1787 H----------------------------RRNRIEQHGTAASLEPISVDSAISSNSTTGGGGSGT 1823
            |                            |...:|...|.|...|:. |....|.:...|..|.|
plant  1545 HIPRGSTWDFVTHFAPPETVAPPSSSSEAREEEVETEETGAMFIPLG-DKETCSFTVNKGDSSRT 1608

  Fly  1824 NNNN-----NNNNNNNSWGGKRLERLGAPQVGLAEQYAFNDRDEISTNISNGRCFVTSKNLKLLK 1883
            .:|.     :..:....|  ::.:.||...:|           .:...||....|...|.:.||
plant  1609 ISNTSPIYASEGSFITCW--QKGQLLGRGSLG-----------SVYEGISADGDFFAFKEVSLL- 1659

  Fly  1884 YDAVRRAKKSHCRVTQAKYAHFQTYVNKWLQQ------HVSEQQQQNCVDWLLGKTADQINASGW 1942
                          .|...||      :|:||      .:|:.|.||.|.: .|.|.|:.|...:
plant  1660 --------------DQGSQAH------EWIQQVEGGIALLSQLQHQNIVRY-RGTTKDESNLYIF 1703

  Fly  1943 GSASKTKTVQQKDTSKTPYRIYNRYRVVQSAVS 1975
                 .:.|.|....|    :|.|.::..|.||
plant  1704 -----LELVTQGSLRK----LYQRNQLGDSVVS 1727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	292/1682 (17%)
WRKY19	NP_001118968.1	Sin3	308..>444	CDD:227889	48/230 (21%)
		PAH	324..368	CDD:460645	19/44 (43%)
		WRKY	467..523	CDD:214815	15/100 (15%)
		WRKY	640..>661	CDD:214815	8/49 (16%)
		PLN03210	663..>1448	CDD:215633	169/955 (18%)
		leucine-rich repeat	1260..1282	CDD:275380	7/39 (18%)
		leucine-rich repeat	1283..1306	CDD:275380	8/37 (22%)
		leucine-rich repeat	1307..1329	CDD:275380	6/23 (26%)
		leucine-rich repeat	1330..1350	CDD:275380	6/30 (20%)
		leucine-rich repeat	1351..1373	CDD:275380	2/21 (10%)
		leucine-rich repeat	1398..1421	CDD:275380	6/26 (23%)
		leucine-rich repeat	1422..1444	CDD:275380	4/23 (17%)
		Protein Kinases, catalytic domain	1626..1877	CDD:473864	33/146 (23%)