DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sin3A and sin3b

DIOPT Version :9

Sequence 1:	NP_001246282.1	Gene:	Sin3A / 36382	FlyBaseID:	FBgn0022764	Length:	2066	Species:	Drosophila melanogaster
Sequence 2:	NP_001038410.1	Gene:	sin3b / 560837	ZFINID:	ZDB-GENE-030131-8264	Length:	1196	Species:	Danio rerio

Alignment Length:	1734	Identity:	571/1734 - (32%)
Similarity:	758/1734 - (43%)	Gaps:	616/1734 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 RLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNM 333
            :||||||||||||||.::.:.|.|||.||||||||||..|||||||.|||.||.||.:|:.|||.
Zfish    35 KLKVEDALSYLDQVKIRFGNDPGIYNKFLDIMKEFKSQSIDTPGVINRVSQLFHGHPDLVLGFNA 99

  Fly   334 FLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPA 398
            ||||||:|||..:.:.......|....|||..|||:
Zfish   100 FLPPGYRIEIPKNGMAFLQSPFSSQVSPGAGRSTGS----------------------------- 135

  Fly   399 AGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSVTNSTAA 463
                :..:|::.|.:::||                        |.|:::       |:...|.|:
Zfish   136 ----SVVSASSSAVVEAAG------------------------PAQNEA-------VTSPESIAS 165

  Fly   464 NAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNASASIVVGGPPTPNSLSELSP 528
            ::..|.|.  |..:..:|...|:.:..||                |.|     |||    ||.|
Zfish   166 SSGPPEQS--SKLSLPLPNRESQSQPAAT----------------SVS-----PPT----SEPS- 202

  Fly   529 HGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKF 593
                                                 ||||:.||:|||||||||.:.|..|:.|
Zfish   203 -------------------------------------PVEFDSAISYVNKIKNRFLDNPETYRAF 230

  Fly   594 LEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQSGQYMS 658
            |||||.||:||..:||........:||.||:::||.||...||||.|||||||||
Zfish   231 LEILHTYQKEQLEVKESRGRSTGGMTEDEVFSKVASLFKGQEDLLAEFGQFLPDA---------- 285

  Fly   659 KSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTS 723
                      ||  :..:||                      :||
Zfish   286 ----------KR--SLFTGG----------------------SLP-------------------- 296

  Fly   724 VSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIG 788

Zfish   297 ----------------------------------------------------------------- 296

  Fly   789 RPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDR 853
                    :...::|..|.                   ..||.|.   |.:   :||:
Zfish   297 --------LKKVEEEELNK-------------------QTKKRPR---PML---LPHM------- 321

  Fly   854 SSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPKPYC-RDVSFSEASSKC 917
                    ||.|                                .|:.|..| :|.||:......
Zfish   322 --------TPLL--------------------------------KKKMKYSCSKDPSFASVGKHG 346

  Fly   918 TISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGP 982
            .:.:..||||||:.|:|.|||:|||||:.|||||:||..|||.||:|||.|||:|...|..|||
Zfish   347 VLREFTFFDKVRRLLKSQEVYENFLRCIALFNQEVVSGAELLQLVTPFLGKFPELYTQFKSFLG- 410

  Fly   983 PSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQST 1047
              .:....:|.|  |:....:|||                   ::||.:||||||:||.|||::.
Zfish   411 --DKELSHVISG--LSDRYMEGGG-------------------REVDYASCKRLGSSYRALPKTY 452

  Fly  1048 VPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEV 1112
            ...|||||||:|:|||||.|||||:| |||||||:|:||.:||    .:||.||||||||:|:|.
Zfish   453 QQPKCSGRTAICKEVLNDTWVSFPSW-SEDSTFVSSKKTPYEE----QLHRCEDERFELDVVLET 512

  Fly  1113 NSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFV 1177
            |.|||||||::|||:||:|.|:..:|.|||.|||||:.|.:||::||||||:.|||.|:|::|..
Zfish   513 NLATIRVLESVQKKLSRLSLEDQERFRLDDCLGGTSEVIQRRAVYRIYGDKAPEIIEGLKRSPAT 577

  Fly  1178 AVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIET 1242
            |||:||||||.|||||||||:.|||.||||.||.||||||||.:|||.|||||||||||.||||:
Zfish   578 AVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQGVNFKQNDMKALRSKSLLNEIES 642

  Fly  1243 LYDERHDQ--EDDAMEPFG-----------PHLVLPYKDKTILDDAANLLIHHVKRQTGIQKQEK 1294
            :||||.:|  |:.::...|           ||::..|:||.||:|||:|:|:|||||..|.|.:|
Zfish   643 IYDERQEQSTEEGSVGQQGRDGTSTASTSEPHMIFNYEDKQILEDAASLIIYHVKRQPTIHKDDK 707

  Fly  1295 QKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTKMDVDSPLGRTESST----RNAKSTP 1355
            ..||:||:.|.||||||.|..||:.|.      ..|:..:.:..:..|...|||    .|.:|..
Zfish   708 DHIKRIIQHFAPDLFFARRGELSETEE------FTDEEGEGEDGAAAGGGVSSTGQQQLNGESRR 766

  Fly  1356 SESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASA 1420
            ....||...:.||                            .|.|..|
Zfish   767 RRCTSPQSMDTST----------------------------VAHSINP----------------- 786

  Fly  1421 ASSSTVSGTEGKPKD--DPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNP 1483
                     ||:..|  ||.:.|::|
Zfish   787 ---------EGEAVDLRDPEAEHQKE--------------------------------------- 803

  Fly  1484 KLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERA--RLL--AIEEERCRV--- 1541
                       .|..|.|||.|||||.|||||..||.||..:|.:|  :||  ..|:.|.|:
Zfish   804 -----------MDGVYNLFFVNNNWYFFLRLHQTLCSRLLKIYRQAERQLLEHRAEQNRERLLMG 857

  Fly  1542 -NRREST---ATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFT 1602
             .|||..   |..||||...|:::|:|||.||||::::||||::|..:|||:||||.|:|||.||
Zfish   858 EGRREKANDLAMELRLKQPSEVELEEYYPAFLDMVRSLLDGNLESTQYEDTLREMFTIHAYIGFT 922

  Fly  1603 LDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEE 1667
            :||::.|.|||||:.|::...|...||:..|::||..||...........|.|||.|||.::.||
Zfish   923 IDKLIQNIVRQLQHLVSDEVCLQVTELYLAERKRGAAGGNLSSQCVRAAWEASYQWKAERVMAEE 987

  Fly  1668 NCFKVYIY--KIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALG 1730
            |||||...  |....:||||||:|..:.|.|  |..|..|.|:|:.
Zfish   988 NCFKVMFIQNKGQVTLTIELLDTEEAQGDDP--LDVQSLSNYMEQY------------------- 1031

  Fly  1731 NDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRSKLLEEQVRQLFEHRRNRIEQH 1795
                     |.||.....||        |...|..||.||.|..:  ..|::|: |..|.|.|.|
Zfish  1032 ---------IGTETLCSQAE--------GYYFKPVFLPRNVRHFR--GWQIKQV-EAMRCRREWH 1076

  Fly  1796 GTAASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGKRLERLGAPQVG-LAEQYAFND 1859
                                                          .::|....| |..::..|.
Zfish  1077 ----------------------------------------------RKMGVETAGNLDCRFKLNT 1095

  Fly  1860 RDEISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHFQTYVNKWLQQHVSEQQQQN 1924
            ...:         ||.:....:.:..|:.:|::|..||.:|::..|:.:...||.:|||...:::
Zfish  1096 HKMV---------FVMNSEDYMYRRGALVKARRSQHRVARAQHERFEQWHRGWLSEHVSPAAERS 1151

  Fly  1925 CVDWLLGKTADQINASGWGSASKTKTV--QQKDTSKTPYRI-YN 1965
            ..|||:|:..:.:      ...||..|  |.|......|:: ||
Zfish  1152 VQDWLMGEEDEDM------IPCKTNCVSLQVKGLHVNRYQVHYN 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	522/1482 (35%)
		PAH	291..335	CDD:280780	31/43 (72%)
		PAH	588..645	CDD:280780	29/56 (52%)
		PAH	936..980	CDD:280780	28/43 (65%)
		Sin3_corepress	1034..1133	CDD:285494	66/98 (67%)
		Sin3a_C	1502..>1710	CDD:293484	103/220 (47%)
sin3b	NP_001038410.1	Sin3	36..1135	CDD:227889	554/1671 (33%)
		PAH	58..101	CDD:280780	31/42 (74%)
		PAH	225..282	CDD:280780	29/56 (52%)
		PAH	365..409	CDD:280780	28/43 (65%)
		Sin3_corepress	439..533	CDD:285494	66/98 (67%)
		Sin3a_C	811..1108	CDD:293484	129/392 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592281
Domainoid	1	1.000	263	1.000	Domainoid score	I1885
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	951	1.000	Inparanoid score	I323
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D198862at33208
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		otm24341
orthoMCL	1	0.900	-	-		OOG6_101145
Panther	1	1.100	-	-	O	PTHR12346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1023
SonicParanoid	1	1.000	-	-		X631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790