Protein Alignment Sin3A and sin3b

DIOPT Version :10

• Sequence 1: NP_001246282.1
• Gene: Sin3A / 36382
• FlyBaseID: FBgn0022764
• Length: 2066
• Species: Drosophila melanogaster
• Sequence 2: NP_001038410.1
• Gene: sin3b / 560837
• ZFINID: ZDB-GENE-030131-8264
• Length: 1196
• Species: Danio rerio
• Alignment Length: 1734
• Identity: 571/1734 - (32%)
• Similarity: 758/1734 - (43%)
• Gaps: 616/1734 - (35%)

  Fly   269 RLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNM 333
            :||||||||||||||.::.:.|.|||.||||||||||..|||||||.|||.||.||.:|:.|||.
Zfish    35 KLKVEDALSYLDQVKIRFGNDPGIYNKFLDIMKEFKSQSIDTPGVINRVSQLFHGHPDLVLGFNA 99

  Fly   334 FLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPA 398
            ||||||:|||..:.:.......|....|||..|||:
Zfish   100 FLPPGYRIEIPKNGMAFLQSPFSSQVSPGAGRSTGS----------------------------- 135

  Fly   399 AGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSVTNSTAA 463
                :..:|::.|.:::||                        |.|:::       |:...|.|:
Zfish   136 ----SVVSASSSAVVEAAG------------------------PAQNEA-------VTSPESIAS 165

  Fly   464 NAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNASASIVVGGPPTPNSLSELSP 528
            ::..|.|.  |..:..:|...|:.:..||                |.|     |||    ||.|
Zfish   166 SSGPPEQS--SKLSLPLPNRESQSQPAAT----------------SVS-----PPT----SEPS- 202

  Fly   529 HGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKF 593
                                                 ||||:.||:|||||||||.:.|..|:.|
Zfish   203 -------------------------------------PVEFDSAISYVNKIKNRFLDNPETYRAF 230

  Fly   594 LEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQSGQYMS 658
            |||||.||:||..:||........:||.||:::||.||...||||.|||||||||
Zfish   231 LEILHTYQKEQLEVKESRGRSTGGMTEDEVFSKVASLFKGQEDLLAEFGQFLPDA---------- 285

  Fly   659 KSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTS 723
                      ||  :..:||                      :||
Zfish   286 ----------KR--SLFTGG----------------------SLP-------------------- 296

  Fly   724 VSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIG 788
                                                                             
Zfish   297 ----------------------------------------------------------------- 296

  Fly   789 RPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDR 853
                    :...::|..|.                   ..||.|.   |.:   :||:
Zfish   297 --------LKKVEEEELNK-------------------QTKKRPR---PML---LPHM------- 321

  Fly   854 SSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPKPYC-RDVSFSEASSKC 917
                    ||.|                                .|:.|..| :|.||:......
Zfish   322 --------TPLL--------------------------------KKKMKYSCSKDPSFASVGKHG 346

  Fly   918 TISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGP 982
            .:.:..||||||:.|:|.|||:|||||:.|||||:||..|||.||:|||.|||:|...|..|||
Zfish   347 VLREFTFFDKVRRLLKSQEVYENFLRCIALFNQEVVSGAELLQLVTPFLGKFPELYTQFKSFLG- 410

  Fly   983 PSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQST 1047
              .:....:|.|  |:....:|||                   ::||.:||||||:||.|||::.
Zfish   411 --DKELSHVISG--LSDRYMEGGG-------------------REVDYASCKRLGSSYRALPKTY 452

  Fly  1048 VPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEV 1112
            ...|||||||:|:|||||.|||||:| |||||||:|:||.:||    .:||.||||||||:|:|.
Zfish   453 QQPKCSGRTAICKEVLNDTWVSFPSW-SEDSTFVSSKKTPYEE----QLHRCEDERFELDVVLET 512

  Fly  1113 NSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFV 1177
            |.|||||||::|||:||:|.|:..:|.|||.|||||:.|.:||::||||||:.|||.|:|::|..
Zfish   513 NLATIRVLESVQKKLSRLSLEDQERFRLDDCLGGTSEVIQRRAVYRIYGDKAPEIIEGLKRSPAT 577

  Fly  1178 AVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIET 1242
            |||:||||||.|||||||||:.|||.||||.||.||||||||.:|||.|||||||||||.||||:
Zfish   578 AVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQGVNFKQNDMKALRSKSLLNEIES 642

  Fly  1243 LYDERHDQ--EDDAMEPFG-----------PHLVLPYKDKTILDDAANLLIHHVKRQTGIQKQEK 1294
            :||||.:|  |:.::...|           ||::..|:||.||:|||:|:|:|||||..|.|.:|
Zfish   643 IYDERQEQSTEEGSVGQQGRDGTSTASTSEPHMIFNYEDKQILEDAASLIIYHVKRQPTIHKDDK 707

  Fly  1295 QKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTKMDVDSPLGRTESST----RNAKSTP 1355
            ..||:||:.|.||||||.|..||:.|.      ..|:..:.:..:..|...|||    .|.:|..
Zfish   708 DHIKRIIQHFAPDLFFARRGELSETEE------FTDEEGEGEDGAAAGGGVSSTGQQQLNGESRR 766

  Fly  1356 SESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASA 1420
            ....||...:.||                            .|.|..|
Zfish   767 RRCTSPQSMDTST----------------------------VAHSINP----------------- 786

  Fly  1421 ASSSTVSGTEGKPKD--DPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNP 1483
                     ||:..|  ||.:.|::|
Zfish   787 ---------EGEAVDLRDPEAEHQKE--------------------------------------- 803

  Fly  1484 KLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERA--RLL--AIEEERCRV--- 1541
                       .|..|.|||.|||||.|||||..||.||..:|.:|  :||  ..|:.|.|:
Zfish   804 -----------MDGVYNLFFVNNNWYFFLRLHQTLCSRLLKIYRQAERQLLEHRAEQNRERLLMG 857

  Fly  1542 -NRREST---ATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFT 1602
             .|||..   |..||||...|:::|:|||.||||::::||||::|..:|||:||||.|:|||.||
Zfish   858 EGRREKANDLAMELRLKQPSEVELEEYYPAFLDMVRSLLDGNLESTQYEDTLREMFTIHAYIGFT 922

  Fly  1603 LDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEE 1667
            :||::.|.|||||:.|::...|...||:..|::||..||...........|.|||.|||.::.||
Zfish   923 IDKLIQNIVRQLQHLVSDEVCLQVTELYLAERKRGAAGGNLSSQCVRAAWEASYQWKAERVMAEE 987

  Fly  1668 NCFKVYIY--KIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALG 1730
            |||||...  |....:||||||:|..:.|.|  |..|..|.|:|:.
Zfish   988 NCFKVMFIQNKGQVTLTIELLDTEEAQGDDP--LDVQSLSNYMEQY------------------- 1031

  Fly  1731 NDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRSKLLEEQVRQLFEHRRNRIEQH 1795
                     |.||.....||        |...|..||.||.|..:  ..|::|: |..|.|.|.|
Zfish  1032 ---------IGTETLCSQAE--------GYYFKPVFLPRNVRHFR--GWQIKQV-EAMRCRREWH 1076

  Fly  1796 GTAASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGKRLERLGAPQVG-LAEQYAFND 1859
                                                          .::|....| |..::..|.
Zfish  1077 ----------------------------------------------RKMGVETAGNLDCRFKLNT 1095

  Fly  1860 RDEISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHFQTYVNKWLQQHVSEQQQQN 1924
            ...:         ||.:....:.:..|:.:|::|..||.:|::..|:.:...||.:|||...:::
Zfish  1096 HKMV---------FVMNSEDYMYRRGALVKARRSQHRVARAQHERFEQWHRGWLSEHVSPAAERS 1151

  Fly  1925 CVDWLLGKTADQINASGWGSASKTKTV--QQKDTSKTPYRI-YN 1965
            ..|||:|:..:.:      ...||..|  |.|......|:: ||
Zfish  1152 VQDWLMGEEDEDM------IPCKTNCVSLQVKGLHVNRYQVHYN 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	522/1482 (35%)
sin3b	NP_001038410.1	Sin3	36..1135	CDD:227889	554/1671 (33%)