DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sin3A and Sin3a

DIOPT Version :9

Sequence 1:	NP_001246282.1	Gene:	Sin3A / 36382	FlyBaseID:	FBgn0022764	Length:	2066	Species:	Drosophila melanogaster
Sequence 2:	NP_001382569.1	Gene:	Sin3a / 363067	RGDID:	1311598	Length:	1274	Species:	Rattus norvegicus

Alignment Length:	1823	Identity:	620/1823 - (34%)
Similarity:	802/1823 - (43%)	Gaps:	627/1823 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 PASAQTVSSSSQTGTIRQRTISGTQTVATAVGN-------LATI--SQQQPVQQSPLGKAQTPPS 244
            |...:.||.:.|:.|..|.:::....|:....:       :|.:  |...|....|.|     ..
  Rat    38 PPVYEAVSETMQSATGIQYSVAPNYQVSAVPQSSGSHGPAIAAVHSSHHHPAAVQPHG-----GQ 97

  Fly   245 SVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCID 309
            .|.:::.|.....|.|||  ....|||||||||||||||.|:..|||:||:||||||||||..||
  Rat    98 VVQSHAHPAPSVAPVQGQ--QQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSID 160

  Fly   310 TPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLT 374
            |||||.|||.|||||.:||.|||.|||||||||:.::      .:|::.:|       |.||.:.
  Rat   161 TPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTN------DMVNVTTP-------GQVHQIP 212

  Fly   375 GNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQ 439
                                                            |||           :|.
  Rat   213 ------------------------------------------------THG-----------IQP 218

  Fly   440 ATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAA 504
            ...|..|.|         :..:|.:|..|.||    :....|...|:..:....||..|..
  Rat   219 QPQPPPQHP---------SQPSAQSAPTPAQP----APQPTPAKVSKPSQLQAHTPASQQT---- 266

  Fly   505 NVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQ--SILLGETG--QQNQ 565
                        ||.|...|..||.                   .|.|.  :|.||...  |.||
  Rat   267 ------------PPLPPYASPRSPP-------------------VQPHTPVTISLGTAPSLQNNQ 300

  Fly   566 PVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKL 630
            ||||||||.||||||||||.||..||.||||||.||:||:..||...|....|||||||.|||:|
  Rat   301 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARL 365

  Fly   631 FGQDEDLLREFGQFLPDATNHQSGQYMSKSA-----SVHNDHGKRPTATLSGGAHITMSSASPAP 690
            |...||||.|||||||||   .|...:||:.     ||.||||
  Rat   366 FKNQEDLLSEFGQFLPDA---NSSVLLSKTTAEKVDSVRNDHG---------------------- 405

  Fly   691 SGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEK 755
                   |....||:                         ||:.|:
  Rat   406 -------GTVKKPQL-------------------------NNKPQR------------------- 419

  Fly   756 DYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQ 820
                                                                          |:|
  Rat   420 --------------------------------------------------------------PSQ 422

  Fly   821 NLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDD 885
            |                                                      |...||
  Rat   423 N------------------------------------------------------GCQIRR---- 429

  Fly   886 SLVGHYASGAPPAKRPKP---YCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTL 947
                |..:||.|..:.||   ..::.|.::||.....:::.|||||||||||.|.|:||||||.:
  Rat   430 ----HSGTGATPPVKKKPKLISLKESSMADASKHGVGTESLFFDKVRKALRSAEAYENFLRCLVI 490

  Fly   948 FNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSH 1012
            ||||::|:.||:.||||||.|||:|..||.:||                         |...|.|
  Rat   491 FNQEVISRAELVQLVSPFLGKFPELFNWFKNFL-------------------------GYKESVH 530

  Fly  1013 DRGTSHQSAAEYV-QDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASE 1076
            ......:.|.|.: .::|.:||||||:||.|||:|....||:|||.||:|||||.|||||:| ||
  Rat   531 LESFPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSW-SE 594

  Fly  1077 DSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLD 1141
            |||||:|:|||:||.||    |.||||||||:|:|.|.|||||||.:|||:||:|.||.:||.||
  Rat   595 DSTFVSSKKTQYEEHIY----RCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLD 655

  Fly  1142 DHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWRE 1206
            :.|||||:.||::|:.|||.||:.:||.|::|||.:||||||||||:|||||||||:.|||.|||
  Rat   656 NTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWRE 720

  Fly  1207 QNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQ--EDDAMEPFGPHLVLPYKDK 1269
            |||||||||||||.||||.||.|.||||||.||||::||||.:|  |::|..|.||||.|.|:||
  Rat   721 QNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDK 785

  Fly  1270 TILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTK 1334
            .||:|||.|:||||||||||||::|.|||||:..|:|||.||.|..|||.|.::
  Rat   786 QILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEE----------- 839

  Fly  1335 MDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATAS 1399
                                                      ::|.|
  Rat   840 ------------------------------------------EEEMD------------------ 844

  Fly  1400 SATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTA 1464
                ||:||                      |.||     .|...|.....|.:..|...||...
  Rat   845 ----VDEAT----------------------GAPK-----KHNGVGGSPPKSKLLFSNTAAQKLR 878

  Fly  1465 GAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERA 1529
            |.                             ||.|.||:.|||||:|:|||.|||.||..:..:|
  Rat   879 GM-----------------------------DEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQA 914

  Fly  1530 RLLAIEEERCRVNRRE----------STATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNT 1584
            .....||.|.|...||          |.|..||||...::.||||||.||||::::||||:||:.
  Rat   915 ERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQ 979

  Fly  1585 FEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKT 1649
            :||::||||.|:|||:||:||::.:.|||||:.|::...:...:|:..|...|.|||........
  Rat   980 YEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQVTDLYLAENNNGATGGQLSSQTSR 1044

  Fly  1650 FDREMSYQRKAESILNEENCFKVYIYKIDCRV--TIELLDSEPEEVDKPAALKAQKFSKYVERLA 1712
            ...|.:||||||.::::|||||:...:...:|  ||||||:|.|..|.|  ::|:::|.||||..
  Rat  1045 SLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDP--VEAERWSDYVERYM 1107

  Fly  1713 NPALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRSKLL 1777
            :                              :|..:.|||...     |.|..||.||.||
  Rat  1108 S------------------------------SDTTSPELREHL-----AQKPVFLPRNLRR---- 1133

  Fly  1778 EEQVRQLFEHRRNRIEQHGTAASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGKRLE 1842
               :|:.   :|.|.:|.                        ..|...|:.....|       :|
  Rat  1134 ---IRKC---QRGREQQE------------------------KEGKEGNSKKTMEN-------VE 1161

  Fly  1843 RLGAPQVGLAEQYAFNDRDEISTNISNGR-CFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHFQ 1906
            .|              |:.|....:::.: .:|......:.:..|:.||.:||.||::..:..||
  Rat  1162 SL--------------DKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQ 1212

  Fly  1907 TYVNKWLQQHVSEQQQQNCVDWLLGKTADQINASGWGSASKTKTVQQKDTSKTPYRIYNRYRVVQ 1971
            .:|:||.::||..:.......||:|:..:       |....|.|.   ||....:....:|||..
  Rat  1213 AWVDKWTKEHVPREMAAETSKWLMGEGLE-------GLVPCTTTC---DTETLHFVSIKKYRVKY 1267

  Fly  1972 SAV 1974
            ..|
  Rat  1268 GTV 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	558/1507 (37%)
		PAH	291..335	CDD:280780	33/43 (77%)
		PAH	588..645	CDD:280780	35/56 (63%)
		PAH	936..980	CDD:280780	27/43 (63%)
		Sin3_corepress	1034..1133	CDD:285494	68/98 (69%)
		Sin3a_C	1502..>1710	CDD:293484	97/219 (44%)
Sin3a	NP_001382569.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350576
Domainoid	1	1.000	269	1.000	Domainoid score	I1779
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32124
Inparanoid	1	1.050	754	1.000	Inparanoid score	I536
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D198862at33208
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		oto98502
orthoMCL	1	0.900	-	-		OOG6_101145
Panther	1	1.100	-	-	LDO	PTHR12346
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.800