DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sin3A and sin3ab

DIOPT Version :9

Sequence 1:	NP_001246282.1	Gene:	Sin3A / 36382	FlyBaseID:	FBgn0022764	Length:	2066	Species:	Drosophila melanogaster
Sequence 2:	XP_009301698.1	Gene:	sin3ab / 323346	ZFINID:	ZDB-GENE-030131-2066	Length:	1269	Species:	Danio rerio

Alignment Length:	1833	Identity:	609/1833 - (33%)
Similarity:	801/1833 - (43%)	Gaps:	648/1833 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 SSSSQTGTIRQRTISGTQTVATAVGNLATISQQQPVQQSPLGKAQTPPSSVVANSIPVGGTTPPQ 260
            |:||...|....|:..:.::..:|..    :.|..:.|:..|...|..|:|.......|....|.
Zfish    32 SASSLFETAAPETMQPSSSMQYSVSQ----TYQLSMPQNSGGHGHTSSSAVHTGPHHHGPAVQPV 92

  Fly   261 GQS-GNATP------------RLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPG 312
            ||: .:|||            |||||||||||||||.|:.:|||:||:||||||||||..|||||
Zfish    93 GQAHSHATPAPAPTLGQQQFQRLKVEDALSYLDQVKLQFGNQPQVYNDFLDIMKEFKSQSIDTPG 157

  Fly   313 VIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNS 377
            ||.|||.|||||.:||.|||.|||||||||:.::.|      |::.:|       |.:|
Zfish   158 VISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDL------VNVTTP-------GQIH------ 203

  Fly   378 SMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHG----GASLTQTTIHALQ 438
                  ||          ||                          ||    ...:||...|..|
Zfish   204 ------HI----------TP--------------------------HGISVQNIPITQPAPHQPQ 226

  Fly   439 QATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAA 503
            .|.|                .|||| .|:|.||        .|...|:..:...:|||.|
Zfish   227 PAPP----------------TSTAA-LVIPSQP--------TPAKISKPMQSPALTPTSQ----- 261

  Fly   504 ANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETG----QQN 564
                          |.|:..|..||.     .|..           |:|..|.....|    |.|
Zfish   262 --------------PNPSIPSYASPR-----SPSV-----------QSHTPISSSTAGSTPLQNN 296

  Fly   565 QPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAK 629
            |||||||||.||||||||||.||..||.||||||.||:||:..||...|....||||:||.|||:
Zfish   297 QPVEFNHAINYVNKIKNRFQGQPEVYKSFLEILHTYQKEQRNAKEAGGNYTPTLTEQQVYAQVAQ 361

  Fly   630 LFGQDEDLLREFGQFLPDATNH----QSGQYMSKSA-----SVHNDHGKRPTATLSGGAHITMSS 685
            ||...||||.|||||||||.:.    .|.|.:||:.     :|..|||
Zfish   362 LFKNQEDLLSEFGQFLPDANSSVLFLSSPQLLSKTTAEKAEAVRIDHG----------------- 409

  Fly   686 ASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRND 750
                        |....||:                         ||:|:.|
Zfish   410 ------------GTVKRPQL-------------------------NNKQRFN------------- 424

  Fly   751 ILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVG 815
                            |.|..:..|
Zfish   425 ----------------QNGCQIRRH---------------------------------------- 433

  Fly   816 HAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATR 880
                                                               |||
Zfish   434 ---------------------------------------------------SGP----------- 436

  Fly   881 RPGDDSLVGHYASGAPPAKRPKPYC-RDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRC 944
                        ...||.|:.:.:. :|.|.:|||.....:::.||:||||||||.|.|||||||
Zfish   437 ------------PTTPPVKKKQKFAVKDPSVAEASKLGIGAESLFFEKVRKALRSSEAYDNFLRC 489

  Fly   945 LTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSN 1009
            |.:||||::|:.||:.||.|||.|||:|..||.:||                         |...
Zfish   490 LVIFNQEVISRAELVQLVLPFLGKFPELFTWFKNFL-------------------------GYRE 529

  Fly  1010 SSHDRGTSHQSAAEYV-QDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTW 1073
            .:|......:.|.|.: .::|.:||||||:||.|||:|....:|:|||.||:|||||.|||||:|
Zfish   530 CAHIESFPKERATEGIAMEIDYASCKRLGSSYRALPKSFQQPRCTGRTPLCKEVLNDTWVSFPSW 594

  Fly  1074 ASEDSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKF 1138
             |||||||:|:|||:||.||    |.||||||||:|:|.|.|||||||.:||::||||.||.:||
Zfish   595 -SEDSTFVSSKKTQYEEHIY----RCEDERFELDVVLETNLATIRVLEAVQKRISRMSAEEQAKF 654

  Fly  1139 HLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQ 1203
            .||:.:||:|:.||::||.||||||:.:||.|:|.||.|:|||||||||:|||||||||:.|||.
Zfish   655 RLDNTIGGSSEVIHRKAIQRIYGDKAPDIIDGLKTNPAVSVPIVLKRLKIKEEEWREAQRGFNKI 719

  Fly  1204 WREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQ--EDDAMEPFGPHLVLPY 1266
            ||||||||||||||||.||||.||.|..|||:|.||||||||||.:|  ||:|..|.|||:.|.|
Zfish   720 WREQNEKYYLKSLDHQGINFKQNDTKVFRSKTLLNEIETLYDERQEQASEDNAAVPSGPHMTLMY 784

  Fly  1267 KDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDD 1331
            :|..||:|||.|:|||||||:||.|.:|.||||||..|:||:.||.|..|||.|.:|      ::
Zfish   785 EDSQILEDAAALIIHHVKRQSGIHKDDKYKIKQIIYHFIPDMLFARRGELSDVEEED------EE 843

  Fly  1332 NTKMDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSA 1396
            .|:.|.|                                    |.||.
Zfish   844 ETEPDED------------------------------------GTKKH----------------- 855

  Fly  1397 TASSATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQ 1461
                    :..|.|.|....:.:|||...:|..
Zfish   856 --------NGTTSSKSKLLFSHTAASQQKLSSC-------------------------------- 880

  Fly  1462 DTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMY 1526
                                              |::|.|||.|||||:|||||.|||.||..:|
Zfish   881 ----------------------------------DDAYNLFFVNNNWYIFLRLHYILCSRLLRIY 911

  Fly  1527 ERARLLAIEEERCRV----------NRRESTATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMD 1581
            .:|.....|:.|.|.          .:.:|.|..||||...:|:|||||..||:|::|:|||||:
Zfish   912 GQAEKQIEEDTREREWERNVLGLKREKNDSPAIQLRLKEPMDIEVEDYYSAFLEMVRNLLDGNME 976

  Fly  1582 SNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDA 1646
            ::.:||.:||||.|:|||:||:||::.:.|||||:.|::...:...:|:.:|.....|||.....
Zfish   977 TSQYEDQLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDDICVQVTDLYLSECANKATGGSLSTQ 1041

  Fly  1647 HKTFDREMSYQRKAESILNEENCFKVYIYKI--DCRVTIELLDSEPEEVDKPAALKAQKFSKYVE 1709
            ....:.|.|||||:|.::::|||||:...|.  ..::.:||||:|.|..|.|  :..:::..|||
Zfish  1042 SSRSNAETSYQRKSEQLMSDENCFKLLFQKSKGTVQLAVELLDTEEENSDGP--VDTERWPDYVE 1104

  Fly  1710 RLANPALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRS 1774
            |..|.                       |....|..|..::            |..||.||.||.
Zfish  1105 RYLNT-----------------------SSASPELREHLSQ------------KPVFLPRNLRRI 1134

  Fly  1775 KLL----EEQVRQLFEHRRNRIEQHGTAASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNS 1835
            :..    |.|:|:..|                       .:..|:.||..|
Zfish  1135 RKCQRGQEMQMREAKE-----------------------TAKKSSEGGDDS-------------- 1162

  Fly  1836 WGGKRLE---RLGAPQVGLAEQYAFNDRDEISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRV 1897
                ::|   :|.:.::    .|.|...|                  .:.:..|..||.:||.||
Zfish  1163 ----KMECMFKLNSYKM----VYVFKSED------------------YMYRRTAQLRAHQSHQRV 1201

  Fly  1898 TQAKYAHFQTYVNKWLQQHVSEQQQQNCVDWLLGKTADQINASGWGSASKTKTVQQKDTSKTPYR 1962
            :...:..||.::::|.::||:.........||:|:..|.:        ...:||.:...  ..::
Zfish  1202 STRLHQRFQMWLDRWRKEHVTSDMAATNHKWLMGEGQDGL--------LPCRTVCEPKI--LHFQ 1256

  Fly  1963 IYNRYRVVQSAVS 1975
            ..|:|:|..|..|
Zfish  1257 NINKYKVTYSTTS 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	554/1526 (36%)
		PAH	291..335	CDD:280780	33/43 (77%)
		PAH	588..645	CDD:280780	34/56 (61%)
		PAH	936..980	CDD:280780	27/43 (63%)
		Sin3_corepress	1034..1133	CDD:285494	67/98 (68%)
		Sin3a_C	1502..>1710	CDD:293484	91/219 (42%)
sin3ab	XP_009301698.1	Sin3	110..1218	CDD:227889	577/1688 (34%)
		PAH	136..180	CDD:280780	33/43 (77%)
		PAH	320..377	CDD:280780	34/56 (61%)
		PAH	481..525	CDD:280780	27/43 (63%)
		Sin3_corepress	555..649	CDD:285494	67/98 (68%)
		Sin3a_C	887..1185	CDD:293484	117/397 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592279
Domainoid	1	1.000	263	1.000	Domainoid score	I1885
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	951	1.000	Inparanoid score	I323
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D198862at33208
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		otm24341
orthoMCL	1	0.900	-	-		OOG6_101145
Panther	1	1.100	-	-	LDO	PTHR12346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1023
SonicParanoid	1	1.000	-	-		X631
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790