DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sin3A and SIN3A

DIOPT Version :9

Sequence 1:	NP_001246282.1	Gene:	Sin3A / 36382	FlyBaseID:	FBgn0022764	Length:	2066	Species:	Drosophila melanogaster
Sequence 2:	NP_001138829.1	Gene:	SIN3A / 25942	HGNCID:	19353	Length:	1273	Species:	Homo sapiens

Alignment Length:	1825	Identity:	624/1825 - (34%)
Similarity:	810/1825 - (44%)	Gaps:	632/1825 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 PASAQTVSSSSQTGTIRQRTISGTQTVAT---AVGN----LATI--SQQQPVQQSPLGKAQTPPS 244
            |...:.||.:.|:.|..|.:::.:..|:.   :.|:    :|.:  |...|....|.|     ..
Human    38 PPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHG-----GQ 97

  Fly   245 SVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCID 309
            .|.:::.|.....|.|||  ....|||||||||||||||.|:..|||:||:||||||||||..||
Human    98 VVQSHAHPAPPVAPVQGQ--QQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSID 160

  Fly   310 TPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLT 374
            |||||.|||.|||||.:||.|||.|||||||||:.::      .:|::.:|       |.||.:.
Human   161 TPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTN------DMVNVTTP-------GQVHQIP 212

  Fly   375 GNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQ 439
                                                            |||           :|.
Human   213 ------------------------------------------------THG-----------IQP 218

  Fly   440 ATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAA 504
            ...|..|.|         :..:|.:|..|.||    :....|...|:..:....||..|..
Human   219 QPQPPPQHP---------SQPSAQSAPAPAQP----APQPPPAKVSKPSQLQAHTPASQQT---- 266

  Fly   505 NVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQ--SILLGETG--QQNQ 565
                        ||.|...|..||.                   .|.|.  :|.||...  |.||
Human   267 ------------PPLPPYASPRSPP-------------------VQPHTPVTISLGTAPSLQNNQ 300

  Fly   566 PVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKL 630
            ||||||||.||||||||||.||..||.||||||.||:||:..||...|....|||||||.|||:|
Human   301 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARL 365

  Fly   631 FGQDEDLLREFGQFLPDATNHQSGQYMSKSA-----SVHNDHGKRPTATLSGGAHITMSSASPAP 690
            |...||||.|||||||||   .|...:||:.     ||.||||
Human   366 FKNQEDLLSEFGQFLPDA---NSSVLLSKTTAEKVDSVRNDHG---------------------- 405

  Fly   691 SGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEK 755
                   |....||:                         ||:.|:
Human   406 -------GTVKKPQL-------------------------NNKPQR------------------- 419

  Fly   756 DYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQ 820
                                                                          |:|
Human   420 --------------------------------------------------------------PSQ 422

  Fly   821 NLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDD 885
            |                                                      |...||
Human   423 N------------------------------------------------------GCQIRR---- 429

  Fly   886 SLVGHYASGAPPAKRPKP---YCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTL 947
                |.....||.|: ||   ..:|.|.::||.....:::.|||||||||||.|.|:||||||.:
Human   430 ----HPTGTTPPVKK-KPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAYENFLRCLVI 489

  Fly   948 FNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSH 1012
            ||||::|:.||:.||||||.|||:|..||.:||                         |...|.|
Human   490 FNQEVISRAELVQLVSPFLGKFPELFNWFKNFL-------------------------GYKESVH 529

  Fly  1013 DRGTSHQSAAEYV-QDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASE 1076
            ......:.|.|.: .::|.:||||||:||.|||:|....||:|||.||:|||||.|||||:| ||
Human   530 LETYPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSW-SE 593

  Fly  1077 DSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLD 1141
            |||||:|:|||:||.||    |.||||||||:|:|.|.|||||||.:|||:||:|.||.:||.||
Human   594 DSTFVSSKKTQYEEHIY----RCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLD 654

  Fly  1142 DHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWRE 1206
            :.|||||:.||::|:.|||.||:.:||.|::|||.:||||||||||:|||||||||:.|||.|||
Human   655 NTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWRE 719

  Fly  1207 QNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQ--EDDAMEPFGPHLVLPYKDK 1269
            |||||||||||||.||||.||.|.||||||.||||::||||.:|  |::|..|.||||.|.|:||
Human   720 QNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDK 784

  Fly  1270 TILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTK 1334
            .||:|||.|:||||||||||||::|.|||||:..|:|||.||.|..|||.|.::
Human   785 QILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEE----------- 838

  Fly  1335 MDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATAS 1399
                                                      ::|.|
Human   839 ------------------------------------------EEEMD------------------ 843

  Fly  1400 SATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTA 1464
                ||:||                                    ||....:||..||.::
Human   844 ----VDEAT------------------------------------GAVKKHNGVGGSPPKS---- 864

  Fly  1465 GAGVDVEIKLEHPADFSNPKLLPPHAHGQR---EDESYTLFFANNNWYLFLRLHAILCDRLHVMY 1526
                               |||..:...|:   .||.|.||:.|||||:|:|||.|||.||..:.
Human   865 -------------------KLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRIC 910

  Fly  1527 ERARLLAIEEERCRVNRRE----------STATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMD 1581
            .:|.....||.|.|...||          |.|..||||...::.||||||.||||::::||||:|
Human   911 SQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNID 975

  Fly  1582 SNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDA 1646
            |:.:||::||||.|:|||:||:||::.:.|||||:.|::...:...:|:..|...|.|||.....
Human   976 SSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQVTDLYLAENNNGATGGQLNTQ 1040

  Fly  1647 HKTFDREMSYQRKAESILNEENCFKVYIYKIDCRV--TIELLDSEPEEVDKPAALKAQKFSKYVE 1709
            :.....|.:||||||.::::|||||:...:...:|  ||||||:|.|..|.|  ::|:::|.|||
Human  1041 NSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDP--VEAERWSDYVE 1103

  Fly  1710 RLANPALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRS 1774
            |..|                              :|..:.|||...     |.|..||.||.||
Human  1104 RYMN------------------------------SDTTSPELREHL-----AQKPVFLPRNLRR- 1132

  Fly  1775 KLLEEQVRQLFEHRRNRIEQHGTAASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGK 1839
                  :|:. :..|.:.|:.|.                         ..|:.....|.:|
Human  1133 ------IRKC-QRGREQQEKEGK-------------------------EGNSKKTMENVDS---- 1161

  Fly  1840 RLERLGAPQVGLAEQYAFNDRDEISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAH 1904
             |::|..       ::..|         |....:|......:.:..|:.||.:||.||::..:..
Human  1162 -LDKLEC-------RFKLN---------SYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQR 1209

  Fly  1905 FQTYVNKWLQQHVSEQQQQNCVDWLLGKTADQINASGWGSASKTKTVQQKDTSKTPYRIYNRYRV 1969
            ||.:|:||.::||..:.......||:|:..:       |....|.|.   ||....:...|:|||
Human  1210 FQAWVDKWTKEHVPREMAAETSKWLMGEGLE-------GLVPCTTTC---DTETLHFVSINKYRV 1264

  Fly  1970 VQSAV 1974
            ....|
Human  1265 KYGTV 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	560/1510 (37%)
		PAH	291..335	CDD:280780	33/43 (77%)
		PAH	588..645	CDD:280780	35/56 (63%)
		PAH	936..980	CDD:280780	27/43 (63%)
		Sin3_corepress	1034..1133	CDD:285494	68/98 (69%)
		Sin3a_C	1502..>1710	CDD:293484	97/219 (44%)
SIN3A	NP_001138829.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Sin3	5..1213	CDD:227889	606/1757 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..110		5/27 (19%)
		Interaction with HCFC1. /evidence=ECO:0000269\|PubMed:12670868	119..196		60/76 (79%)
		Interaction with REST. /evidence=ECO:0000250	205..480		138/589 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..297		32/205 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..446		24/245 (10%)
		Interaction with SAP30. /evidence=ECO:0000250\|UniProtKB:Q60520	458..525		41/91 (45%)
		Interaction with NCOR1. /evidence=ECO:0000250\|UniProtKB:Q60520	523..850		213/442 (48%)
		Interaction with SUDS3 and SAP130. /evidence=ECO:0000269\|PubMed:12724404	524..659		82/139 (59%)
		Interaction with HDAC1 and ARID4B. /evidence=ECO:0000269\|PubMed:12724404	687..829		103/141 (73%)
		Interaction with OGT. /evidence=ECO:0000269\|PubMed:12150998	888..967		37/78 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1136..1156		4/45 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156661
Domainoid	1	1.000	269	1.000	Domainoid score	I1864
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32124
Inparanoid	1	1.050	849	1.000	Inparanoid score	I437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D198862at33208
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		otm42104
orthoMCL	1	0.900	-	-		OOG6_101145
Panther	1	1.100	-	-	LDO	PTHR12346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1023
SonicParanoid	1	1.000	-	-		X631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790