Protein Alignment Sin3A and pst2

DIOPT Version :9

• Sequence 1: NP_001246282.1
• Gene: Sin3A / 36382
• FlyBaseID: FBgn0022764
• Length: 2066
• Species: Drosophila melanogaster
• Sequence 2: NP_593646.1
• Gene: pst2 / 2541624
• PomBaseID: SPAC23C11.15
• Length: 1075
• Species: Schizosaccharomyces pombe
• Alignment Length: 1565
• Identity: 296/1565 - (18%)
• Similarity: 481/1565 - (30%)
• Gaps: 654/1565 - (41%)

  Fly   263 SGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTEL 327
            :|.|.|.|   |..:::.::..:...:|.:|:.|:|::|...:..:|.||.|||:|.:.:.:.:|
pombe    30 NGTALPEL---DIKAFVQKLGQRLCHRPYVYSAFMDVVKALHNEIVDFPGFIERISVILRDYPDL 91

  Fly   328 IYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNA 392
            :...|:|||..||.
pombe    92 LEYLNIFLPSSYKY--------------------------------------------------- 105

  Fly   393 ATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSV 457
                                        |:::.||:.|      ||..||....|
pombe   106 ----------------------------LLSNSGANFT------LQFTTPSGPVS---------- 126

  Fly   458 TNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNASASIVVGGPPTPNS 522
                                                ||:..||                  |.|.
pombe   127 ------------------------------------TPSTYVA------------------TYND 137

  Fly   523 LSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQP 587
            |                                          |..::.||.:|::::....:.|
pombe   138 L------------------------------------------PCTYHRAIGFVSRVRRALLSNP 160

  Fly   588 AKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQ 652
            .::.|..:.|..::.     .|.||:        |:.|.|..|..:...|..||..|||.:
pombe   161 EQFFKLQDSLRKFKN-----SECSLS--------ELQTIVTSLLAEHPSLAHEFHNFLPSS---- 208

  Fly   653 SGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNL 717
                                        |...|..|        ||:..|..|..|..  .:.|:
pombe   209 ----------------------------IFFGSKPP--------LGSFPLRGIQSSQF--TLSNI 235

  Fly   718 SAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTA 782
            |                               |:|
pombe   236 S-------------------------------DLL------------------------------ 239

  Fly   783 AGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHIS 847
                                                              |...|..:....|:|
pombe   240 --------------------------------------------------SQSRPDNLSPFSHLS 254

  Fly   848 DNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPKPYCRDVSFSE 912
            :.|.|
pombe   255 NESSD------------------------------------------------------------ 259

  Fly   913 ASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFT 977
                       ||..|:..|...|.|..||:.|.|:.|.|:.:..|:.....||.....|.|.|.
pombe   260 -----------FFKNVKNVLTDVETYHEFLKLLNLYVQGIIDRNILVSRGFGFLKSNSGLWRSFL 313

  Fly   978 DFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCA 1042
            ..                           :|.|..:..:.:.||..     |...|   |.||..
pombe   314 SL---------------------------TSLSPEEFLSVYNSACS-----DFPEC---GPSYRL 343

  Fly  1043 LPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRNIHRTEDERFELD 1107
            ||.......||||......:|||.|||.||||||:|.|:..|||.:||.    :.:.|:||:|.|
pombe   344 LPVEERNISCSGRDDFAWGILNDDWVSHPTWASEESGFIVQRKTPYEEA----MTKLEEERYEFD 404

  Fly  1108 LVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIY-GDKSGEIITGM 1171
            ..||..|.||:.|:.:|.:::.:..||...:.|::.||..|::|:::.|..:| .:.:.|:...:
pombe   405 RHIEATSWTIKSLKKIQNRINELPEEERETYTLEEGLGLPSKSIYKKTIKLVYTSEHAEEMFKAL 469

  Fly  1172 KKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSL 1236
            ::.|.:.:|:|:.||:.|.|||:..:::....||....|.|.||||.|.:.||..|.|.:.||.|
pombe   470 ERMPCLTLPLVISRLEEKNEEWKSVKRSLQPGWRSIEFKNYDKSLDSQCVYFKARDKKNVSSKFL 534

  Fly  1237 FNEIETLYDER--HD--QEDDAMEPFGPHLVLPYKDKTILDDAANLLIHHV--KRQTGIQKQEKQ 1295
            ..|.:.|..:.  |.  :...|.|     ....|.::.:|.|...::..::  ...:|::|.|.
pombe   535 LAEADILRSQAKLHFPLRSRSAFE-----FSFVYDNEIVLFDTCYMVCTYIVCNSPSGLKKVEH- 593

  Fly  1296 KIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDD---NTKMDVDSP--LGRTESSTRNAKSTP 1355
                         ||....||......|.|...:|.   ....||::|  :|......:.:.|..
pombe   594 -------------FFKNILPLHFGLEKDKFSIFLDQVFRGPDYDVNAPNIVGNKPVRRKRSNSIT 645

  Fly  1356 --SESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAA 1418
              :|.....:.|....|.:.|..:|:.:....:..:...:.|..:.:.|||.....|..:||..|
pombe   646 QLTEFVKQPKINGQRESRSAAAARKKEESGNKSQSNSQNSLSDESGNVTPVSKKQLSQPAAAIKA 710

  Fly  1419 SAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNP 1483
            |....|         ..|.|..|                   ||.||   |.|.::....|
pombe   711 SLKYPS---------HPDSLLEH-------------------QDHAG---DTENEMHDDVD---- 740

  Fly  1484 KLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEERCRVNRRESTA 1548
                      :|.      |..::.|:|.||..:|.:||   ||..||    |::..:.::
pombe   741 ----------KEQ------FGYSSMYVFFRLFNLLYERL---YELQRL----EDQVSIIQQ---- 778

  Fly  1549 TALRLKPKPEIQ--------------VED---YYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIY 1596
               |:.|.|..|              |.|   :|.....|:..::.|.:|.:.|||.:|..:|..
pombe   779 ---RIIPNPVSQKQKIWRDRWNDLSDVPDEKTHYENTYVMILRLIYGIVDQSAFEDYLRFYYGNK 840

  Fly  1597 AYISFTLDKVVSNAVRQLQYCVTERAALDCVELFAT---EQRRGCTGGFCRDAHKTFDREMSYQR 1658
            ||..:|:||:|.:|.:|:.:.|:     |....|.|   ||....:      ..|.:| :..|:.
pombe   841 AYKIYTIDKLVWSAAKQVHHIVS-----DGKYKFVTSLVEQNSSAS------PKKNYD-DFLYRL 893

  Fly  1659 KAESILNEE---------NCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVERLANP 1714
            :.|.:||.:         |.||.:..||..|..:        .||:....:.:.:.|||:.....
pombe   894 EIEKLLNPDEILFRFCWINKFKSFGIKIMKRANL--------IVDQSLDTQRRVWKKYVQNYRIQ 950

  Fly  1715 ALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRSKLLEE 1779
            .|                               |.|:.|:.      .:..||.||..:.:.:|:
pombe   951 KL-------------------------------TEEISYKN------YRCPFLCRNIEKERTVEQ 978

  Fly  1780 QVRQL 1784
            .|.:|
pombe   979 LVSRL 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	286/1498 (19%)
		PAH	291..335	CDD:280780	13/43 (30%)
		PAH	588..645	CDD:280780	12/56 (21%)
		PAH	936..980	CDD:280780	14/43 (33%)
		Sin3_corepress	1034..1133	CDD:285494	40/98 (41%)
		Sin3a_C	1502..>1710	CDD:293484	59/236 (25%)
pst2	NP_593646.1	Sin3	1..1075	CDD:227889	296/1565 (19%)
		PAH	56..99	CDD:280780	13/42 (31%)
		PAH	272..312	CDD:280780	13/39 (33%)
		Sin3_corepress	335..430	CDD:285494	41/101 (41%)
		Sin3a_C	744..1016	CDD:293484	70/311 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	87	1.000	Domainoid score	I2139
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		otm47392
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.870