DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sin3A and pst1

DIOPT Version :9

Sequence 1:	NP_001246282.1	Gene:	Sin3A / 36382	FlyBaseID:	FBgn0022764	Length:	2066	Species:	Drosophila melanogaster
Sequence 2:	NP_596012.2	Gene:	pst1 / 2540018	PomBaseID:	SPBC12C2.10c	Length:	1522	Species:	Schizosaccharomyces pombe

Alignment Length:	1825	Identity:	435/1825 - (23%)
Similarity:	658/1825 - (36%)	Gaps:	602/1825 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 YSVASIQAGGTLKANTADGANTVQIHVTGGGAANNPASAQ-------TVSSSSQTGTIRQR--TI 209
            |...:.|...|...|.|:|...|.    ||..:..|...|       ||.|:|....|.|:  .:
pombe    81 YRNVNTQVSHTAIPNPANGYAAVY----GGPPSQLPPPPQPQSHPNVTVISASPARAIEQQPTIL 141

  Fly   210 SGTQTVATAVGNLATISQQQPVQQSPLGKAQTPPSSVVANSIPVGGTTPPQGQSGNATPRLKVED 274
            |.|.:      |:     .:|      |..::..|..|.|..|.....|||...     :|.|.|
pombe   142 SSTDS------NI-----PRP------GTVKSSASPFVPNQNPSAPPPPPQEYR-----QLNVTD 184

  Fly   275 ALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGY 339
            ||||||.||.|:..:|:|||.||||||||||..|:||.||.|||.||.|:..||.|||.||||||
pombe   185 ALSYLDLVKLQFHQEPEIYNEFLDIMKEFKSQAIETPEVITRVSKLFAGYPNLIQGFNTFLPPGY 249

  Fly   340 KIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPAAGAGAA 404
            .|||.|             :.||   |...:|:.|..      |.:.|......|..|
pombe   250 SIEISS-------------ADPG---SLAGIHITTPQ------GPLMINDLGKTTAPP------- 285

  Fly   405 AAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSVTNSTAANAVVPG 469
                                                 ||          |.|.|...||
pombe   286 -------------------------------------PP----------HGSTTPLPAA------ 297

  Fly   470 QPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNASASIVVGGPPTPNSLS-ELSPHGGAG 533
               .|.::.|:.|                         :|||..|..||.|::|. ..||...|.
pombe   298 ---ASYTSMNMKQ-------------------------SSASHPVLQPPAPSTLQFNPSPSPAAP 334

  Fly   534 GGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILH 598
            ..|...|:      ::||               .:.:.||.:||.:||||.::|..|..||:||.
pombe   335 SYPPVDAS------VKQA---------------ADLDQAINFVNNVKNRFSHKPEAYNSFLDILK 378

  Fly   599 DYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQSGQYMSKSASV 663
            .||.:|:.:             |.||.||::||.:..|||.||.:||||.:.:...:...||..|
pombe   379 SYQHDQRPI-------------QLVYFQVSQLFAEAPDLLEEFKRFLPDVSVNAPAETQDKSTVV 430

  Fly   664 HNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKT 728
            ..:                  ||:..|..||.....:.||.|.|
pombe   431 PQE------------------SATATPKRSPSATPTSALPPIGK--------------------- 456

  Fly   729 YNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVG 793
                                    |.....|..|....:|.                  |.|.|
pombe   457 ------------------------FAPPTTAKAQPAPEKRR------------------GEPAV- 478

  Fly   794 ASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGI 858
                                      |...|....:.:.|                |::.::|
pombe   479 --------------------------QTRNHSKRTRTATS----------------SVEETTP-- 499

  Fly   859 SYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPKPYCRDVSFSEASSKCTISDAA 923
                                            .|...|.|:...|                |:..
pombe   500 --------------------------------RAFNVPIAQNKNP----------------SELE 516

  Fly   924 FFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPA 988
            |.:..|:.|.:...|:.|::.|.|::||:..|..|:.....|......|:.|..|.:......|
pombe   517 FLEHARQYLANESKYNEFIKLLELYSQEVFDKNALVERCYVFFGSNEHLMNWLKDLVKYNPANP- 580

  Fly   989 GGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQSTVPKKCS 1053
                  :|:...:                          |||:.||..|.||..||:..:...||
pombe   581 ------IPVPRPR--------------------------VDLTQCKSCGPSYRLLPKIELLLPCS 613

  Fly  1054 GRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEVNSATIR 1118
            ||..||..:|||.||||||.|||||.|:..||.||||    |:|:.|:||:|.|..|..|...|.
pombe   614 GRDDLCWTILNDAWVSFPTLASEDSGFIAHRKNQFEE----NLHKLEEERYEYDRHIGANMRFIE 674

  Fly  1119 VLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYG-DKSGEIITGMKKNPFVAVPIV 1182
            :|:....||.:||..|.:.:.|..:|||.|.:|:.:.|.::|| :.:.:||..::|||.|.:|||
pombe   675 LLQIHADKMLKMSEVEKANWTLPSNLGGKSVSIYHKVIKKVYGKEHAQQIIENLQKNPSVTIPIV 739

  Fly  1183 LKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDER 1247
            |:|||.|:.|||..|..:|:.|.:..||.:.:|||||.::||..|.|:...|.|.:|:..|..::
pombe   740 LERLKKKDREWRSLQNHWNELWHDIEEKNFYRSLDHQGVSFKSVDKKSTTPKFLISELRNLAQQQ 804

  Fly  1248 HDQEDDAMEPFGPHLVLPYKDKTILDDAANL----LIHHVKRQTGIQKQEKQKIKQIIRQFVPDL 1308
            ..:..:.........:..|||..|:.|.|.|    |||......    ::.:|:...:|.|: .|
pombe   805 KVELSEGKVTPSHQFLFSYKDPNIITDIARLFGVFLIHGSTHSA----EDNEKMSNFLRSFL-SL 864

  Fly  1309 FFAPRQPLSDDERDDAFPFLVD--DNTKMDVDSPLGRTESSTRNAKSTPSESASP---ARSNAST 1368
            ||       |...|...|:|..  :..:.|:||     .||:...|  |..|:||   |.:|
pombe   865 FF-------DVPYDSFIPYLPTHFNEEESDIDS-----LSSSLIEK--PRASSSPIHHANNN--- 912

  Fly  1369 SSVTPAGIKKETDDSKAT-TGSFAPASSATASSATPVDDATPSTSSAAAAASAASSSTVSGTEGK 1432
                  |::...|..|.| .|:....||......:...:.||..|..
pombe   913 ------GLRLLKDVLKKTYRGARENRSSVKEDYVSESTERTPDASEI------------------ 953

  Fly  1433 PKDDPLSSHKE---EGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQR 1494
              |:.:|.|:|   |.:...|:|......:..||.|:.:|...||
pombe   954 --DEHISEHEENDDESSSVFSTGEVWVNCKFTDTDGSLLDDGTKL-------------------- 996

  Fly  1495 EDESYTLFFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEERCRVNRRESTATALRLKPKPEI 1559
            .|.|....|.|.:.|.|.||...|..||..:....::...::...:.|   ..|..|.|...|..
pombe   997 SDRSVYNLFGNMSLYCFFRLFHTLYSRLEEIKNLEQMAYSKQHDVKSN---PVAVELGLVRHPSE 1058

  Fly  1560 QV-------EDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYC 1617
            ::       :..|...:.:.:.:::|.:|.|.|||.:|.::||:|:..:|::|:|::.::||...
pombe  1059 RLGFALPTADTVYEQAIQLCERLMEGEIDQNGFEDALRCLYGIHAFRLYTVEKLVTSIIKQLHSV 1123

  Fly  1618 VTERAALDCVELFATE--QRRGCTGGFCRDAHKTFDR-EMSYQRKAESILN-EENCFKVYIYKID 1678
            .|.|........:..:  |||            |..| ::.|:.:.|:... :||...:......
pombe  1124 TTNRRLAQVFMYYEKDRVQRR------------TSPRQQIMYRIQTETAFGPDENLCCIDWNSQT 1176

  Fly  1679 CRVTIELLDSEPEEVDKPAALK--AQKFSKYVER--LANPALG------------------GGGN 1721
            .:..|.|:..|...:   ..||  |:|:..|:..  :::|..|                  .|..
pombe  1177 RQSAIRLMGREDLTM---GTLKSDAEKWCYYIGSYIMSSPTEGILPEHVRIPFLRKCLPSDEGNE 1238

  Fly  1722 TGRSDSALGNDSVVDGSDIKT----EADEDTAELRYREGG------------IGGAGKARFLVRN 1770
            ...|.|.:.:.:.:..|.:::    ....:|.::||..|.            .|...|    :|:
pombe  1239 DDESSSVVKSANAIITSFLESGLALTIPINTVKIRYENGTEDVFARNSEQVYNGPYDK----IRD 1299

  Fly  1771 KRRSK--------------LLEEQVRQLFEHRRNRIEQHGTAASLEPISVDSAISSNSTTGGGGS 1821
            .|:||              |.:::||:                 ::|.:::|..:.::...|...
pombe  1300 YRQSKWREWLNSDEGWTQGLSKDKVRR-----------------IKPCTIESLFNESTLRSGKAE 1347

  Fly  1822 GTNNN--------NNNNNNNNSWGGKRLERLGAPQVGLAEQYAFNDRDEISTNISNGRCFVTSKN 1878
            ..:.|        ...|..|.|..||:|::...|:|                   ||:..||..|
pombe  1348 RFSENAGVESIGKKGKNLLNESGNGKKLDKGLPPKV-------------------NGKSSVTRGN 1393

  Fly  1879 LKLLK 1883
            ...||
pombe  1394 KTNLK 1398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	377/1528 (25%)
		PAH	291..335	CDD:280780	29/43 (67%)
		PAH	588..645	CDD:280780	20/56 (36%)
		PAH	936..980	CDD:280780	12/43 (28%)
		Sin3_corepress	1034..1133	CDD:285494	48/98 (49%)
		Sin3a_C	1502..>1710	CDD:293484	49/220 (22%)
pst1	NP_596012.2	Sin3	42..1315	CDD:227889	413/1704 (24%)
		PAH	201..245	CDD:280780	29/43 (67%)
		PAH	368..412	CDD:280780	20/56 (36%)
		PAH	530..573	CDD:280780	12/42 (29%)
		HDAC_interact	592..693	CDD:214808	50/104 (48%)
		Sin3a_C	1004..1282	CDD:293484	59/295 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	109	1.000	Domainoid score	I1636
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I325
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		otm47392
orthoMCL	1	0.900	-	-		OOG6_101145
Panther	1	1.100	-	-	LDO	PTHR12346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1023
SonicParanoid	1	1.000	-	-		X631
TreeFam	1	0.960	-	-
	12	11.850