Protein Alignment Sin3A and pst3

DIOPT Version :9

• Sequence 1: NP_001246282.1
• Gene: Sin3A / 36382
• FlyBaseID: FBgn0022764
• Length: 2066
• Species: Drosophila melanogaster
• Sequence 2: NP_595433.1
• Gene: pst3 / 2539793
• PomBaseID: SPBC1734.16c
• Length: 1154
• Species: Schizosaccharomyces pombe
• Alignment Length: 1807
• Identity: 343/1807 - (18%)
• Similarity: 542/1807 - (29%)
• Gaps: 745/1807 - (41%)

  Fly   188 NPASAQT-VSSSSQTGTIRQRTISGTQTVATAVGNLATISQQQPVQQSPLGKAQTPPSSVVANSI 251
            :|:.:|: |::|...|..:.      ..|||.......|..::.|.:....|.:|..||:..:||
pombe    32 SPSQSQSPVNTSLHNGDGKD------NGVATEPVENKQILSERSVTRDDYEKGKTIVSSLALSSI 90

  Fly   252 P-VGGTTPPQ---GQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPG 312
            . ..|:...|   |.|.::...|.|.||||||:.|||.::::.:|||.||:||::|||..:||.|
pombe    91 SGKDGSISSQNAEGLSSSSNRPLDVNDALSYLELVKYYFSERREIYNRFLEIMRDFKSQALDTLG 155

  Fly   313 VIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNS 377
            ||.|||.||.|:.:||.|||.|||.|||||:..|:...||..|..|..|
pombe   156 VINRVSELFNGYPQLIEGFNTFLPSGYKIEVQLDSSNTSVVRVGTPMHP---------------- 204

  Fly   378 SMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATP 442
                              .|..|..:....|...:.|                    ..::..:|
pombe   205 ------------------LPQQGVQSTLPVAPSNEDQ--------------------RTMESTSP 231

  Fly   443 PQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVN 507
            ..||                                  ||
pombe   232 TDSQ----------------------------------PQ------------------------- 237

  Fly   508 ASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHA 572
                     |..||                                  |:..|..:...|:||:|
pombe   238 ---------PSAPN----------------------------------LVSSTENEKPRVDFNYA 259

  Fly   573 ITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDL 637
            |.|:||:|.|:......|.:||.:|..||:.||.:             .||..:||::|....||
pombe   260 IAYMNKVKARYPPNSDTYMEFLGVLRTYQKAQKSI-------------FEVRARVAEIFKDSPDL 311

  Fly   638 LREFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTL 702
            |.||..||||                                  .:.|..|            :.
pombe   312 LEEFKLFLPD----------------------------------NVDSTEP------------ST 330

  Fly   703 PQIDKSAH-AAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAH 766
            |.:.||.: ...:||.| :..|..::...|
pombe   331 PNVQKSPNRLPPVGNFS-LPPSAPVREKRN----------------------------------- 359

  Fly   767 QRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHR-----NNHHVQKYVGHAPNQNLTHGH 826
                                  ||...|.:..|..|..|     ....:..|..|...|.:|
pombe   360 ----------------------RPAHSAQISRSISKTSRMYRQTAEEPLNSYSLHVYPQKIT--- 399

  Fly   827 NAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHY 891
                                                  .|:.|                     |
pombe   400 --------------------------------------APTSP---------------------Y 405

  Fly   892 ASGAPPAKRPKPYCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKT 956
            |:                        |..:...|..:|:.|.....:..||..|.|:.::::.||
pombe   406 AA------------------------TQEELLAFTTIRQHLPDTLAFHKFLELLHLYREKLLDKT 446

  Fly   957 ELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSA 1021
            |||...|. |::..:|..||::|: ..|..|.  |:...|:
pombe   447 ELLNSFSK-LVRNDNLTLWFSEFI-RWSDNPI--LVKNEPV------------------------ 483

  Fly  1022 AEYVQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKT 1086
            .|.|...:...|  :..:|..||.|....|||||..|...||||.::|.....|.....:
pombe   484 DERVYLPETFEC--ISLTYRKLPDSWKQDKCSGRDDLDNSVLNDDYISVAPKPSHVKNIM----- 541

  Fly  1087 QFEETIYRNIHRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLG--GTSQ 1149
            ..|....:.:...||||::.|.|:....:.|::|.|.        .|.....||:..|.  ..|:
pombe   542 HHENQYLQALQLVEDERYDYDRVLNTTESAIKILANF--------CEPTIHEHLETALQELERSK 598

  Fly  1150 TIHQRAIHRIYGDKSGEII--TGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYY 1212
            .|.:.|:..:||.:...:.  |..||.| .|.|::|||:|.|::|||.:::.::|.||:..:|..
pombe   599 RIIKNALIIVYGKEHANLALDTLFKKLP-TAAPVLLKRIKTKDQEWRRSKREWSKIWRQIEKKNA 662

  Fly  1213 LKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFGPHLVLPYKDKTILDDAAN 1277
            ..:.|.:....:..|.:.|....:..:|:.:|..:..:.|.|.        |.::...:|.|  :
pombe   663 QAAFDDRYCRIEGRDRRGLSYSRILRDIDDIYQRQKHRIDGAK--------LGFQFTQVLCD--S 717

  Fly  1278 LLIHHVKRQTGIQ--------KQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTK 1334
            |:..::.|.:..|        ..:|.:|..:::..:...|
pombe   718 LIFLNILRLSDAQLTNSSFYSYADKGRISAVLKALLSQFF------------------------- 757

  Fly  1335 MDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATAS 1399
               ..||.| |:...|..|...||....|...|...:.|    :..|:|..|..||       .:
pombe   758 ---GIPLPR-EALETNLASENIESVKKHRDGLSKIFIRP----ESADNSNNTNVSF-------QT 807

  Fly  1400 SATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTA 1464
            ..|..:|.|.|
pombe   808 DETQTEDETMS------------------------------------------------------ 818

  Fly  1465 GAGVDVEIKLEHPADFSNPKLLPPHAHGQRE---DESYTL----FFANNNWYLFLRLHAILCDRL 1522
                |:     ||.|..|        |.:.:   :||..:    ||.|...|:..||   :|
pombe   819 ----DI-----HPDDVEN--------HSKSKFLGEESKNIIGYNFFGNATMYVLFRL---IC--- 860

  Fly  1523 HVMYERARLLAIEEERCRVNRRESTATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFED 1587
             |.|.|...:.:..|...:....:..                |...|::.:..|.|:.....|..
pombe   861 -VCYSRLEHIKLFVESSTIYASSTGG----------------YENILNICEKYLKGSCSRLEFRK 908

  Fly  1588 TMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDR 1652
            .:::......|:..::::::.....::...:.:......:.||.::.....|         |...
pombe   909 YLQKFNNETCYMICSIERLLKVIFYRIHEILLDPKLGQLLLLFESDGANSVT---------TPRE 964

  Fly  1653 EMSYQRKAESIL-NEENCFKVYIYKIDCRVTIELL---DSEPEEVDKPAALKAQKFSKYVERLAN 1713
            :|.|:...|||| .|...|.:..|.::.|:.|:.|   |....:.:.|    |:.|..||:..|
pombe   965 QMVYRNHVESILAPESKIFNMRWYPLEKRLCIQQLLPADLTMHDFENP----AKAFMYYVDSYA- 1024

  Fly  1714 PALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRSKLLE 1778
                             ...:.:|.|:.
pombe  1025 -----------------ISHITEGVDLM------------------------------------- 1035

  Fly  1779 EQVRQLFEHRR-NRIEQHGTAASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGKRLE 1842
             ||:..|..|. .||.|.|..|                  |.|||                 ||.
pombe  1036 -QVKMPFLRRSLQRISQQGYLA------------------GRGSG-----------------RLH 1064

  Fly  1843 RLGAPQVGLAEQYAFNDRDEISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHF-- 1905
            .|            ||:.            |..| ||:|.              .:...|..|
pombe  1065 SL------------FNEH------------FCKS-NLQLF--------------FSTDTYVIFFE 1090

  Fly  1906 ----QTYVNK---WLQQHVSEQQQQNCVDWLLGKTADQINASGWGSASKTKT 1950
                ..|:|.   |:.|....::|....:|.....:|:    || ..||..|
pombe  1091 PNTENVYINSYNLWVDQSSQSKKQNRTTNWRRWLESDE----GW-RKSKANT 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	294/1513 (19%)
		PAH	291..335	CDD:280780	26/43 (60%)
		PAH	588..645	CDD:280780	18/56 (32%)
		PAH	936..980	CDD:280780	14/43 (33%)
		Sin3_corepress	1034..1133	CDD:285494	26/98 (27%)
		Sin3a_C	1502..>1710	CDD:293484	39/211 (18%)
pst3	NP_595433.1	Sin3	1..1152	CDD:227889	343/1807 (19%)
		PAH	134..178	CDD:280780	26/43 (60%)
		PAH	275..319	CDD:280780	18/56 (32%)
		HDAC_interact	492..592	CDD:214808	30/114 (26%)
		Sin3a_C	846..1096	CDD:293484	67/415 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		otm47392
orthoMCL	1	0.900	-	-		OOG6_101145
Panther	1	1.100	-	-	O	PTHR12346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X631
TreeFam	1	0.960	-	-
	8	7.770