DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sin3A and Sin3a

DIOPT Version :9

Sequence 1:	NP_001246282.1	Gene:	Sin3A / 36382	FlyBaseID:	FBgn0022764	Length:	2066	Species:	Drosophila melanogaster
Sequence 2:	NP_001103820.1	Gene:	Sin3a / 20466	MGIID:	107157	Length:	1277	Species:	Mus musculus

Alignment Length:	1824	Identity:	619/1824 - (33%)
Similarity:	801/1824 - (43%)	Gaps:	626/1824 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 PASAQTVSSSSQTGTIRQRTISGTQTVATAVGN-------LATI--SQQQPVQQSPLGKAQTPPS 244
            |...:.||.:.|:.|..|.:::....|:....:       :|.:  |...|....|.|     ..
Mouse    38 PPVYEAVSETMQSATGIQYSVAPNYQVSAVPQSSGSHGPAIAAVHSSHHHPTAVQPHG-----GQ 97

  Fly   245 SVVANSIPVGGTTPPQGQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCID 309
            .|.:::.|.....|.|||  ....|||||||||||||||.|:..|||:||:||||||||||..||
Mouse    98 VVQSHAHPAPPVAPVQGQ--QQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSID 160

  Fly   310 TPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLT 374
            |||||.|||.|||||.:||.|||.|||||||||:.::      .:|::.:|       |.||.:.
Mouse   161 TPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTN------DMVNVTTP-------GQVHQIP 212

  Fly   375 GNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQ 439
                                                            |||           :|.
Mouse   213 ------------------------------------------------THG-----------IQP 218

  Fly   440 ATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAA 504
            ...|..|.|         :..::.:|..|.||....:|..|    |:..:....||..|..
Mouse   219 QPQPPPQHP---------SQPSSQSAPTPAQPAPQPTAAKV----SKPSQLQAHTPASQQT---- 266

  Fly   505 NVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQ--SILLGETG--QQNQ 565
                        ||.|...|..||.                   .|.|.  :|.||...  |.||
Mouse   267 ------------PPLPPYASPRSPP-------------------VQPHTPVTISLGTAPSLQNNQ 300

  Fly   566 PVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKL 630
            ||||||||.||||||||||.||..||.||||||.||:||:..||...|....|||||||.|||:|
Mouse   301 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARL 365

  Fly   631 FGQDEDLLREFGQFLPDATNHQSGQYMSKSA-----SVHNDHGKRPTATLSGGAHITMSSASPAP 690
            |...||||.|||||||||   .|...:||:.     ||.||||
Mouse   366 FKNQEDLLSEFGQFLPDA---NSSVLLSKTTAEKVDSVRNDHG---------------------- 405

  Fly   691 SGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEK 755
                   |....||:                         ||:.|:
Mouse   406 -------GTVKKPQL-------------------------NNKPQR------------------- 419

  Fly   756 DYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQ 820
                                                                          |:|
Mouse   420 --------------------------------------------------------------PSQ 422

  Fly   821 NLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDD 885
            |                                                      |...||
Mouse   423 N------------------------------------------------------GCQIRR---- 429

  Fly   886 SLVGHYASGAPPAKRPKP---YCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTL 947
                |..:||.|..:.||   ..::.|.::||.....:::.|||||||||||.|.|:||||||.:
Mouse   430 ----HSGTGATPPVKKKPKLMSLKESSMADASKHGVGTESLFFDKVRKALRSAEAYENFLRCLVI 490

  Fly   948 FNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSH 1012
            ||||::|:.||:.||||||.|||:|..||.:||                         |...|.|
Mouse   491 FNQEVISRAELVQLVSPFLGKFPELFNWFKNFL-------------------------GYKESVH 530

  Fly  1013 DRGTSHQSAAEYV-QDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASE 1076
            ......:.|.|.: .::|.:||||||:||.|||:|....||:|||.||:|||||.|||||:| ||
Mouse   531 LESFPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSW-SE 594

  Fly  1077 DSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLD 1141
            |||||:|:|||:||.||    |.||||||||:|:|.|.|||||||.:|||:||:|.||.:||.||
Mouse   595 DSTFVSSKKTQYEEHIY----RCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLD 655

  Fly  1142 DHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWRE 1206
            :.|||||:.||::|:.|||.||:.:||.|::|||.:||||||||||:|||||||||:.|||.|||
Mouse   656 NTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWRE 720

  Fly  1207 QNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQ--EDDAMEPFGPHLVLPYKDK 1269
            |||||||||||||.||||.||.|.||||||.||||::||||.:|  |::|..|.||||.|.|:||
Mouse   721 QNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDK 785

  Fly  1270 TILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTK 1334
            .||:|||.|:||||||||||||::|.|||||:..|:|||.||.|..|||.|.::
Mouse   786 QILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEE----------- 839

  Fly  1335 MDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATAS 1399
                                                      ::|.|
Mouse   840 ------------------------------------------EEEMD------------------ 844

  Fly  1400 SATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTA 1464
                ||:||                      |.||     .|...|.....|.:..|...||...
Mouse   845 ----VDEAT----------------------GAPK-----KHNGVGGSPPKSKLLFSNTAAQKLR 878

  Fly  1465 GAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERA 1529
            |.                             ||.|.||:.|||||:|:|||.|||.||..:..:|
Mouse   879 GM-----------------------------DEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQA 914

  Fly  1530 RLLAIEEERCRVNRRE----------STATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNT 1584
            .....||.|.|...||          |.|..||||...::.||||||.||||::::||||:||:.
Mouse   915 ERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQ 979

  Fly  1585 FEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKT 1649
            :||::||||.|:|||:||:||::.:.|||||:.|::...:...:|:..|...|.|||........
Mouse   980 YEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQVTDLYLAENNNGATGGQLNSQTSR 1044

  Fly  1650 FDREMSYQRKAESILNEENCFKVYIYKIDCRV--TIELLDSEPEEVDKPAALKA-QKFSKYVERL 1711
            ...|.:||||||.::::|||||:...:...:|  |:||||:|.|..|.|...:. .::|.||||.
Mouse  1045 SLLESAYQRKAEQLMSDENCFKLMFIQSQGQVQLTVELLDTEEENSDDPVEAEVWTRWSDYVERY 1109

  Fly  1712 ANPALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRSKL 1776
            .:                              :|..:.|||...     |.|..||.||.||
Mouse  1110 MS------------------------------SDTTSPELREHL-----AQKPVFLPRNLRR--- 1136

  Fly  1777 LEEQVRQLFEHRRNRIEQHGTAASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGKRL 1841
                :|:.   :|.|.:|.                        ..|...|:.....|       :
Mouse  1137 ----IRKC---QRGREQQE------------------------KEGKEGNSKKTMEN-------V 1163

  Fly  1842 ERLGAPQVGLAEQYAFNDRDEISTNISNGR-CFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHF 1905
            |.|              |:.|....:::.: .:|......:.:..|:.||.:||.||::..:..|
Mouse  1164 ESL--------------DKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRF 1214

  Fly  1906 QTYVNKWLQQHVSEQQQQNCVDWLLGKTADQINASGWGSASKTKTVQQKDTSKTPYRIYNRYRVV 1970
            |.:|:||.::||..:.......||:|:..:       |....|.|.   ||....:...|:|||.
Mouse  1215 QAWVDKWTKEHVPREMAAETSKWLMGEGLE-------GLVPCTTTC---DTETLHFVSINKYRVK 1269

  Fly  1971 QSAV 1974
            ...|
Mouse  1270 YGTV 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	556/1508 (37%)
		PAH	291..335	CDD:280780	33/43 (77%)
		PAH	588..645	CDD:280780	35/56 (63%)
		PAH	936..980	CDD:280780	27/43 (63%)
		Sin3_corepress	1034..1133	CDD:285494	68/98 (69%)
		Sin3a_C	1502..>1710	CDD:293484	95/220 (43%)
Sin3a	NP_001103820.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Sin3	8..1217	CDD:227889	601/1756 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..110		5/29 (17%)
		Interaction with HCFC1. /evidence=ECO:0000250\|UniProtKB:Q96ST3	119..196		60/76 (79%)
		Interaction with REST. /evidence=ECO:0000269\|PubMed:10734093	205..479		136/587 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..297		32/205 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..443		22/241 (9%)
		Interaction with SAP30. /evidence=ECO:0000269\|PubMed:9702189	459..526		41/91 (45%)
		Interaction with NCOR1	524..851		213/428 (50%)
		Interactions with SUDS3 and SAP130. /evidence=ECO:0000250	525..660		82/139 (59%)
		Interactions with HDAC1 and ARID4B. /evidence=ECO:0000250	688..830		103/141 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..865		12/131 (9%)
		Interaction with OGT. /evidence=ECO:0000250	889..968		37/78 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1140..1160		5/46 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847071
Domainoid	1	1.000	269	1.000	Domainoid score	I1840
eggNOG	1	0.900	-	-		E1_COG5602
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32124
Inparanoid	1	1.050	854	1.000	Inparanoid score	I429
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D198862at33208
OrthoFinder	1	1.000	-	-		FOG0000820
OrthoInspector	1	1.000	-	-		otm44157
orthoMCL	1	0.900	-	-		OOG6_101145
Panther	1	1.100	-	-	LDO	PTHR12346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1023
SonicParanoid	1	1.000	-	-		X631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790