DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sin3A and sin-3

DIOPT Version :9

Sequence 1:NP_001246282.1 Gene:Sin3A / 36382 FlyBaseID:FBgn0022764 Length:2066 Species:Drosophila melanogaster
Sequence 2:NP_001122442.1 Gene:sin-3 / 172628 WormBaseID:WBGene00004117 Length:1507 Species:Caenorhabditis elegans


Alignment Length:1783 Identity:354/1783 - (19%)
Similarity:601/1783 - (33%) Gaps:590/1783 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 PVGA-GAQVAVGVGSA-----AGGGGVVVSTGSTGTQTLQYTTSYSVASIQAGGTLK-------- 166
            |:|. ..|.||....|     |.|..:....||    .||.:.|.:.:::|....|.        
 Worm    88 PLGLFQVQAAVQAAQAQFAQNAQGSPIPFHIGS----PLQPSHSPAASALQQQYLLPSHSPAITP 148

  Fly   167 -ANTADGANTVQIHVTGGGAANNPASAQTVSSSSQTGTIRQRTISGTQTVATAVGNLATISQQQP 230
             |..::.|..::..:....|||.|.:    :|..|:..||..    .|..|..:.||.:..|.|.
 Worm   149 FARNSEAARNIEQFIAQEEAANVPRA----NSQQQSPLIRPI----PQQQALNIQNLTSTQQAQQ 205

  Fly   231 V----QQSPLGKAQ------TPPSSV-------VANSIP-----VGGTT-------PPQGQSG-- 264
            :    :|.|:.:.|      |||.::       ::|.:|     |..|:       |.|.|.|  
 Worm   206 ILAHHRQVPVQQVQHQQHIPTPPLALPIAQQGPISNEVPSVPPVVPATSAGCPQREPRQQQGGRR 270

  Fly   265 -NATPRLK-------VEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLF 321
             |...|.|       |::||:||..:|..::....:|:.||:|||:|::..|:||.|||:|:.|.
 Worm   271 QNRPGRRKKPEGPPRVDEALAYLRVIKSTFSSDVPVYHRFLEIMKDFRAQRIETPDVIEQVAELL 335

  Fly   322 KGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIA 386
            ....||:.|||.|||.||:|.:..|.      .....||...|                      
 Worm   336 YDSPELVLGFNTFLPTGYRITLTPDR------KYVFSSPQMQP---------------------- 372

  Fly   387 IKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGG 451
                 ...|:|......|..|.|    |:.||:.|                              
 Worm   373 -----RVLLSPDERRARAIEAGA----QAVGAIEL------------------------------ 398

  Fly   452 HVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNASASIVVGG 516
                            ..|.|||.......::...|:.:    ....|.|..             
 Worm   399 ----------------GSQEGISKDEDRTIEDEDMDKSK----EKDDVDGID------------- 430

  Fly   517 PPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQN-----QPVEFN-----H 571
                   .|.....|..........:.:.|.|::    |:..:..:.:     |.:|.:     |
 Worm   431 -------DEDDEESGIEDKNNEEMMEEDNHLIEE----IICDDRKKDDCEDSQQEIEMSSELAAH 484

  Fly   572 AITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDED 636
            .:..:..:|..|..:|.|...|:..:..:..:|:..|:                 :.||...|||
 Worm   485 TLNIIELLKKSFLARPTKLVDFMTFIDFFMSDQQYKKD-----------------MEKLRKDDED 532

  Fly   637 LLREFGQFL-----PDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLH 696
            ...|..:.:     |..:|  :.|.:.|...:......:........:...:|..:....|.|..
 Worm   533 DEIEENEKIEVDDVPGPSN--APQEIKKPDDIEKKDSSKNLQIEESCSDYLVSMLANCCIGEPDL 595

  Fly   697 LGATT--LPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDI-----LFE 754
            |.||.  ||.:.|    ..:....|:  ::.|||          ::.......||||     :..
 Worm   596 LAATIDFLPYLGK----LLVNGSDAI--ALKIKT----------ILHFSATNDRNDIPPVNRVNP 644

  Fly   755 KDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPN 819
            .|....|.:|..:...|...:..|....||.  |..|....:|: ..|.:|..:...| ....||
 Worm   645 SDVDMDLVKQMEKCKMGTKKNEKLKLKVAGQ--GDEGATVELMI-LKKSYRILYERLK-SRTTPN 705

  Fly   820 QNLTHGH---NAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRR 881
            | |:|..   ||..:.......:|..:|.|...|                               
 Worm   706 Q-LSHLMVLINAYANLDITREQLISELPKIMGTS------------------------------- 738

  Fly   882 PGDD------SLVGHYASGAPPAKRPKPYCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDN 940
             |.|      .|:|   :...|..||:   .|:            ||.    :||.|        
 Worm   739 -GSDLEMIILQLLG---AEKEPKNRPE---NDM------------DAV----MRKDL-------- 772

  Fly   941 FLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGG 1005
                                                      |:.||..||.|            
 Worm   773 ------------------------------------------PAIQPKRGLRD------------ 783

  Fly  1006 GSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQSTVPKKCSGRTAL---CREVLNDKW 1067
                         |...:.|::|:.::...||.|| ...:.|....||||..|   .:.||||.|
 Worm   784 -------------QKMLQQVKNVEAATVCTLGPSY-RFMKDTKATDCSGRVELDDDLKGVLNDTW 834

  Fly  1068 VSFPTWASEDSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEVNSATIRVLENLQKKMSRMST 1132
            .|.|:|:|||:.....:|:..||..:    :|||||:|||::::.|...|..|....:....||.
 Worm   835 TSIPSWSSEDTGSQAIKKSNLEEFHF----KTEDERYELDIIVDSNRTVIEQLSKTLRDYEAMSD 895

  Fly  1133 EELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQ 1197
            |:...|.||..|..:|::...|.:.:::.:.:.:.|...:|||.|.:..:|:.||.|:..|...|
 Worm   896 EDKKSFKLDKWLNASSRSTTIRVLAKVFTNSAQDFIDAAQKNPLVGLRRILESLKEKDLLWSRFQ 960

  Fly  1198 KTFNKQWREQNEKYYLKS---LDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFG 1259
            :..|:.||:..:|....:   |::|..|:   |.||.:||.|.|:||.:.:||  :::::.:. .
 Worm   961 QDTNRTWRDALDKQMSAATTILNNQHKNY---DQKAFKSKPLVNQIEQICEER--RKNNSTDT-S 1019

  Fly  1260 PHLVLPY-KDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQII---RQFVPDLFFAPRQPLSDDE 1320
            |||:|.| .::.:..|..::..|.....:| .|.::.:.|.::   |..:..|....:|...|.:
 Worm  1020 PHLILEYTPERKVYRDVNDVTGHFFHDLSG-TKCDRDRTKIVLFSYRILMEWLCQEGQQVQIDLD 1083

  Fly  1321 RDDAFPFLVDDN------TKMDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKE 1379
            ..:.|.|..|.|      |.:::|   ||.....|                     |.|.....|
 Worm  1084 NGEIFKFQGDLNEDENLMTLLNMD---GRRICGDR---------------------VVPVSTSLE 1124

  Fly  1380 TDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEE 1444
            :::|                                                             
 Worm  1125 SNES------------------------------------------------------------- 1128

  Fly  1445 GAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWY 1509
                                        .::|   ||.      :.|.:|...:   |:.:::.|
 Worm  1129 ----------------------------SIDH---FSE------NLHQKRTRRT---FYGDDSVY 1153

  Fly  1510 LFLRLHAILCDRLHVMYER-ARLLAIEE-------ERCRVNRRESTATALRLKPKPEIQ------ 1560
            :.:|.|       |::.|| |::|:.:.       :..:.|:|........:..:..:|      
 Worm  1154 MIIRYH-------HMIQERFAKILSTQAIYAQEHFDNQKKNKRWEDGIGADMHGRKALQENIKQR 1211

  Fly  1561 ---VEDY----------YPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVR 1612
               |.|.          |.|.|..||.:.:..||...||:.::.:|.....:...:||:.|:..:
 Worm  1212 RAAVNDIRNVRSCPSSSYETTLRELKQLGNAQMDIVAFEEAVKNLFPGDIVLFNNIDKLFSSLAK 1276

  Fly  1613 QLQY--CVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDRE---MSYQRKAESILNEENCFKV 1672
            .:.:  |..||.  :.::|:...::|      ..:|.:..|.|   ..|.:.||.:|..:|.::.
 Worm  1277 NIHHATCAEERE--NPIKLYLKYRQR------IMNAERDEDMESVIQEYGQTAEEVLRGKNTYRF 1333

  Fly  1673 YIYKIDCR--VTIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRS--DSALGNDS 1733
            ...:...:  :.|.::..|.::.|.....:..:..|..:.:.:...||.|. ||.  |......|
 Worm  1334 EFVEEQNKPFIKIWVIPREEKDDDDDDDEEGNEGGKDEDNVKDEDDGGDGE-GRDGPDDDQPPPS 1397

  Fly  1734 VVDGSDIKTEADEDTAELRYREGGIGGA 1761
            ..||.|.:.|.||        |.|..||
 Worm  1398 NDDGDDEEDEDDE--------EDGPSGA 1417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sin3ANP_001246282.1 Sin3 238..1719 CDD:227889 305/1596 (19%)
PAH 291..335 CDD:280780 20/43 (47%)
PAH 588..645 CDD:280780 10/56 (18%)
PAH 936..980 CDD:280780 0/43 (0%)
Sin3_corepress 1034..1133 CDD:285494 37/101 (37%)
Sin3a_C 1502..>1710 CDD:293484 44/241 (18%)
sin-3NP_001122442.1 Sin3 271..>1062 CDD:227889 226/1082 (21%)
PAH 306..349 CDD:280780 20/42 (48%)
HDAC_interact 801..900 CDD:214808 38/103 (37%)
Sin3a_C 1146..>1341 CDD:293484 40/209 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166699
Domainoid 1 1.000 65 1.000 Domainoid score I6676
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 246 1.000 Inparanoid score I2040
Isobase 1 0.950 - 0 Normalized mean entropy S4104
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D198862at33208
OrthoFinder 1 1.000 - - FOG0000820
OrthoInspector 1 1.000 - - oto19603
orthoMCL 1 0.900 - - OOG6_101145
Panther 1 1.100 - - LDO PTHR12346
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1023
SonicParanoid 1 1.000 - - X631
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1312.880

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