DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and CLC-A

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_198905.1	Gene:	CLC-A / 834090	AraportID:	AT5G40890	Length:	775	Species:	Arabidopsis thaliana

Alignment Length:	799	Identity:	247/799 - (30%)
Similarity:	403/799 - (50%)	Gaps:	98/799 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LDDSQPLLMGNNSVPPDIPING-SAGSPNRNINSSEPIFHLRSRTAAASTP---------NYESL 117
            :|:...|.:.|::      .|| ..|....|...::|:  |:.....:|||         :.|||
plant     1 MDEDGNLQISNSN------YNGEEEGEDPENNTLNQPL--LKRHRTLSSTPLALVGAKVSHIESL 57

  Fly   118 DYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYN 182
            |||:.||.||:.:.|.| ::....:...::|.:...:|:.|.|||..|::.:|  :|..|..|
plant    58 DYEINENDLFKHDWRSR-SKAQVFQYIFLKWTLACLVGLFTGLIATLINLAVE--NIAGYKLL-- 117

  Fly   183 SVKENVPLSDASDRDLLIPYLYW---LLFS-----IVPVAFGAAMVTYIEPITAGSGIPQVKSYL 239
                .|....|.||       :|   ::|:     :..||  ..:|.|..|..||.|||::|:||
plant   118 ----AVGYYIAQDR-------FWTGLMVFTGANLGLTLVA--TVLVVYFAPTAAGPGIPEIKAYL 169

  Fly   240 NGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKA 304
            ||:..|.:....|:.||.:|.|.:|..||..|||||::|.|:.:|:.:.||........:|..:.
plant   170 NGIDTPNMFGFTTMMVKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGPDNHRIKWRWLRY 234

  Fly   305 FRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLS 369
            |.:|.::||.:..|.|:||.|||.:|:||:||:|||.|::|...|:|||..::.:.|    :||.
plant   235 FNNDRDRRDLITCGSASGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVV----VVLR 295

  Fly   370 AYHGLNDFTFTGLFNLG---KFD---TPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKI----N 424
            |:..:.:....|||..|   .||   ..:::...::....::||.||:||:.:|.|..|:    |
plant   296 AFIEICNSGKCGLFGSGGLIMFDVSHVEVRYHAADIIPVTLIGVFGGILGSLYNHLLHKVLRLYN 360

  Fly   425 KFRKRFIPWKIGKVLEAVVVAMMGVTLACLM-IYFINDCRPLGND-----PTN----NPVQLFCE 479
            ...::   .||.|||.::.|::.  |..||. :.|:.:|:|....     |||    |..|..|.
plant   361 LINQK---GKIHKVLLSLGVSLF--TSVCLFGLPFLAECKPCDPSIDEICPTNGRSGNFKQFNCP 420

  Fly   480 DNEYNAVAALWFQTPEATVRSLF-HDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTAL 543
            :..||.::.|...|.:..||::| .:.|....:::|.:|..:|.:|...|||:....|:|:|..|
plant   421 NGYYNDLSTLLLTTNDDAVRNIFSSNTPNEFGMVSLWIFFGLYCILGLITFGIATPSGLFLPIIL 485

  Fly   544 VGAAWGRLL--AMLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFF 606
            :|:|:||:|  ||.:|....|      |.||::|||:.:.|.:|||:||.||.:|.|  ......
plant   486 MGSAYGRMLGTAMGSYTNIDQ------GLYAVLGAASLMAGSMRMTVSLCVIFLELT--NNLLLL 542

  Fly   607 PL-IIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREI--LSKPVICIKIRDS 668
            |: :..|:.||.|||.||..||:..:.:..:|.|...|.|..:.|...|:  ...||:.:...:.
plant   543 PITMFVLLIAKTVGDSFNLSIYEIILHLKGLPFLEANPEPWMRNLTVGELNDAKPPVVTLNGVEK 607

  Fly   669 ANYIYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKR---FWLPETS 730
            ...|.::|:...||.|||:|.  .|:.:...:.|:|||:.|:.:|.|..::..||   .|.....
plant   608 VANIVDVLRNTTHNAFPVLDG--ADQNTGTELHGLILRAHLVKVLKKRWFLNEKRRTEEWEVREK 670

  Fly   731 IQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVI 795
            . |..:|..|..:...|.....::...|||....|.:|..|....||.:...:||::|||||||:
plant   671 F-TPVELAEREDNFDDVAITSSEMQLYVDLHPLTNTTPYTVVQSMSVAKALVLFRSVGLRHLLVV 734

  Fly   796 -----NHENRIAGIITRRD 809
                 :..:.:.||:||:|
plant   735 PKIQASGMSPVIGILTRQD 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	44/144 (31%)
		ClC_6_like	115..639	CDD:239657	183/555 (33%)
		Voltage_CLC	213..620	CDD:279048	147/430 (34%)
		CBS	653..811	CDD:223591	48/167 (29%)
CLC-A	NP_198905.1	ClC_6_like	55..576	CDD:239657	183/555 (33%)
CLC-A	NP_198905.1	CBS_pair_voltage-gated_CLC_euk_bac	596..757	CDD:341367	47/161 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	238	1.000	Domainoid score	I595
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	361	1.000	Inparanoid score	I584
OMA	1	1.010	-	-		QHG53783
OrthoDB	1	1.010	-	-		D410280at2759
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		otm2727
orthoMCL	1	0.900	-	-		OOG6_101210
Panther	1	1.100	-	-	O	PTHR11689
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1393
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840