DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and AT5G33280

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_198313.2	Gene:	AT5G33280 / 833300	AraportID:	AT5G33280	Length:	765	Species:	Arabidopsis thaliana

Alignment Length:	775	Identity:	240/775 - (30%)
Similarity:	394/775 - (50%)	Gaps:	90/775 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 PNRNINSSEPIFHLRS-RTAAASTPN----------YESLDYEVCENTLFQDEQRKR-LTERFSL 141
            ||.....|..:..|.| |.|..||..          .||||||:.||..|:.:.|.| ..|.|
plant     2 PNSTTEDSVAVPLLPSLRRATNSTSQVAIVGANVCPIESLDYEIAENDFFKQDWRGRSKVEIF-- 64

  Fly   142 RKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWL 206
            :...::|::...||||.:||....::.:|.|:..|:.     |..|:.::..    ..:.::.:.
plant    65 QYVFMKWLLCFCIGIIVSLIGFANNLAVENLAGVKFV-----VTSNMMIAGR----FAMGFVVFS 120

  Fly   207 LFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGG 271
            :.:::...|.:.:..::.|..||||||:||:|||||..|.|..::||.:|.||.|::|...|..|
plant   121 VTNLILTLFASVITAFVAPAAAGSGIPEVKAYLNGVDAPEIFSLRTLIIKIIGNISAVSASLLIG 185

  Fly   272 KEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLF 336
            |.|||:|.||.||:.:.||.|..:...:|..:.|::|.::||.|..|.|||::|:|.||:||:||
plant   186 KAGPMVHTGACVASILGQGGSKRYRLTWRWLRFFKNDRDRRDLVTCGAAAGIAASFRAPVGGVLF 250

  Fly   337 SLEEAASFWNQNLIWR----TLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKFDTPLKFDYF 397
            :|||.:|:|...|:||    |.|.:|:....:::.||..        .|||..|..   :.||.:
plant   251 ALEEMSSWWRSALLWRIFFSTAVVAIVLRALIDVCLSGK--------CGLFGKGGL---IMFDVY 304

  Fly   398 E----------LPIFMILGVTGGLLGAAWNSLNTKI----NKFRKRFIPWKIGKVLEAVVVAMMG 448
            .          ||: ::|||.||:||:.:|.|..|:    |...::.:.|||      ::...:.
plant   305 SENASYHLGDVLPV-LLLGVVGGILGSLYNFLLDKVLRAYNYIYEKGVTWKI------LLACAIS 362

  Fly   449 VTLACLM--IYFINDCRPLGND-----PT----NNPVQLFCEDNEYNAVAALWFQTPEATVRSLF 502
            :..:||:  :.|:..|:|...|     ||    .|..:..|....||.:|:|.|.|.:..:::||
plant   363 IFTSCLLFGLPFLASCQPCPVDALEECPTIGRSGNFKKYQCPPGHYNDLASLIFNTNDDAIKNLF 427

  Fly   503 -HDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQAEFL 566
             .:........::.:|.|..:.||..::|:....|:|:|..:.||::||.:.||    ......|
plant   428 SKNTDFEFHYFSVLVFFVTCFFLSIFSYGIVAPAGLFVPVIVTGASYGRFVGML----LGSNSNL 488

  Fly   567 HPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFP-LIIALISAKWVGDYFNEGIYDTQ 630
            :.|.:|::|||:.|||.:|||:|..|||:|.|  ......| :::.|:.:|.|.|.||..||:..
plant   489 NHGLFAVLGAASFLGGTMRMTVSTCVILLELT--NNLLLLPMMMVVLLISKTVADGFNANIYNLI 551

  Fly   631 IQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRR 695
            :::...|.|.....|..:.|...::::.|:......:....|..:||..:||||||||   |...
plant   552 MKLKGFPYLYSHAEPYMRQLLVGDVVTGPLQVFNGIEKVETIVHVLKTTNHNGFPVVD---GPPL 613

  Fly   696 SEGRVC-GIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDLYP-----RFPSIKSVRKLDEKI 754
            :...|. |:|||:.::.:|.|.:::.:.......|..|...:.:.     |...|:.|...:|::
plant   614 AAAPVLHGLILRAHILTLLKKRVFMPSPVACDSNTLSQFKAEEFAKKGSGRSDKIEDVELSEEEL 678

  Fly   755 NYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVI-NHENR--IAGIITRRDFI 811
            |..:||..|.|.||..|....|:.:...:||.:|:|||||| ...||  :.||:||.||:
plant   679 NMYLDLHPFSNASPYTVVETMSLAKALILFREVGIRHLLVIPKTSNRPPVVGILTRHDFM 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	49/145 (34%)
		ClC_6_like	115..639	CDD:239657	176/555 (32%)
		Voltage_CLC	213..620	CDD:279048	145/437 (33%)
		CBS	653..811	CDD:223591	51/166 (31%)
AT5G33280	NP_198313.2	Voltage_gated_ClC	39..561	CDD:295552	176/556 (32%)
		Voltage_CLC	125..541	CDD:279048	145/439 (33%)
		CBS_pair_EriC_assoc_euk_bac	580..738	CDD:239964	51/160 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	238	1.000	Domainoid score	I595
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56546
Inparanoid	1	1.050	361	1.000	Inparanoid score	I584
OMA	1	1.010	-	-		QHG53783
OrthoDB	1	1.010	-	-		D410280at2759
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		otm2727
orthoMCL	1	0.900	-	-		OOG6_101210
Panther	1	1.100	-	-	O	PTHR11689
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840