Protein Alignment ClC-b and CLC-D

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_197996.1
• Gene: CLC-D / 832693
• AraportID: AT5G26240
• Length: 792
• Species: Arabidopsis thaliana
• Alignment Length: 772
• Identity: 255/772 - (33%)
• Similarity: 405/772 - (52%)
• Gaps: 90/772 - (11%)

  Fly    89 PNRNINSSEPIFHLRSRTAAASTPNYESLDYEVCENTLFQDEQ--RKRLTERFSLRKDIIRWIIF 151
            |..:..|::.|..|.|........|  ||||||.||..:::||  |.:|...:.:   .::|...
plant    21 PESDDTSTDDITLLNSHRDGDGGVN--SLDYEVIENYAYREEQAHRGKLYVGYYV---AVKWFFS 80

  Fly   152 IQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFG 216
            :.|||.|.|.|..|::.:|..:..|:...:..::          :.....::.:||.::|.|...
plant    81 LLIGIGTGLAAVFINLSVENFAGWKFALTFAIIQ----------KSYFAGFIVYLLINLVLVFSS 135

  Fly   217 AAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGA 281
            |.::|...|..||||||::|.||||:.||..:..:||..|..|.|.||.||||.|||||::|.||
plant   136 AYIITQFAPAAAGSGIPEIKGYLNGIDIPGTLLFRTLIGKIFGSIGSVGGGLALGKEGPLVHTGA 200

  Fly   282 VVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWN 346
            .:|:.:.||.||.:..:.|..:.|:.|.::||.|..|.||||:|||.||:||:||:|||..|:|.
plant   201 CIASLLGQGGSTKYHLNSRWPQLFKSDRDRRDLVTCGCAAGVAAAFRAPVGGVLFALEEVTSWWR 265

  Fly   347 QNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKF------DTPLKFDYFELPIFMIL 405
            ..|:||....|.|    :.:|:....|.......|.|..|.|      |....:.:.||....::
plant   266 SQLMWRVFFTSAI----VAVVVRTAMGWCKSGICGHFGGGGFIIWDVSDGQDDYYFKELLPMAVI 326

  Fly   406 GVTGGLLGAAWNSLNTKINKFRKRFIPWKIG--KVLEAVVVAMM--GVTLACLMIYFINDC---- 462
            ||.||||||.:|.|...:..:|:..:..|..  |::||.:::.:  .::....::...:.|
plant   327 GVIGGLLGALFNQLTLYMTSWRRNSLHKKGNRVKIIEACIISCITSAISFGLPLLRKCSPCPESV 391

  Fly   463 --------RPLGNDPTNNPVQLFCE-DNEYNAVAALWFQTPEATVRSLFHDPPGSHKIL------ 512
                    ||.|  ...|.|..||: |||||.:|.::|.|.:..:|:||     |.|.:
plant   392 PDSGIECPRPPG--MYGNYVNFFCKTDNEYNDLATIFFNTQDDAIRNLF-----SAKTMREFSAQ 449

  Fly   513 TLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQAEFLHPGKYALIGAA 577
            :|..|..::|.|:..|||..|..|.|:|..::|:.:|||:.|.....:.:.. :..|.|||:|||
plant   450 SLLTFLAMFYTLAVVTFGTAVPAGQFVPGIMIGSTYGRLVGMFVVRFYKKLN-IEEGTYALLGAA 513

  Fly   578 ANLGGVLRMTISLSVILMETTGVETSFFFPLI-IALISAKWVGDYFNEGIYDTQIQVNHVPMLTW 641
            :.|||.:|||:||.||::|.|  ......||| :.|:.:|.|||.||||:|:.|.::..:|:|
plant   514 SFLGGSMRMTVSLCVIMVEIT--NNLKLLPLIMLVLLISKAVGDAFNEGLYEVQARLKGIPLL-- 574

  Fly   642 EPLPQY--------KGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRSEG 698
            |..|:|        :..::::::|.|.: |::.|.|:    :|....||||||:|..   |..|.
plant   575 ESRPKYHMRQMIAKEACQSQKVISLPRV-IRVADVAS----ILGSNKHNGFPVIDHT---RSGET 631

  Fly   699 RVCGIILRSQLIVILLKSLYVENKRFWLP-ETSIQTFRDLYPRFPS--------IKSVRKLDEKI 754
            .|.|::|||.|:|:|...  |:.:...|| :.|.:..|..:..|..        |:.:....:.:
plant   632 LVIGLVLRSHLLVLLQSK--VDFQHSPLPCDPSARNIRHSFSEFAKPVSSKGLCIEDIHLTSDDL 694

  Fly   755 NYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            ...:||:.|:||||..|....|:.:::.:||.||||||.|:...:|:.|:|||:|.:
plant   695 EMYIDLAPFLNPSPYVVPEDMSLTKVYNLFRQLGLRHLFVVPRPSRVIGLITRKDLL 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	191/555 (34%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	54/169 (32%)
		CBS repeat	657..763	CDD:341367	32/114 (28%)
		CBS repeat	769..812	CDD:341367	17/43 (40%)
CLC-D	NP_197996.1	ClC_6_like	45..574	CDD:239657	192/557 (34%)
		CBS_pair_voltage-gated_CLC_euk_bac	593..751	CDD:341367	54/167 (32%)
		CBS repeat	593..703	CDD:341367	32/119 (27%)
		CBS repeat	709..751	CDD:341367	17/41 (41%)