Protein Alignment ClC-b and clcn4

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001070786.1
• Gene: clcn4 / 768175
• ZFINID: ZDB-GENE-061013-353
• Length: 768
• Species: Danio rerio
• Alignment Length: 854
• Identity: 238/854 - (27%)
• Similarity: 391/854 - (45%)
• Gaps: 222/854 - (25%)

  Fly    72 GNNSVPPDIPINGSAG------SPNRNINSSEPIFHLRSRTAAASTPNYESLDY--EVCENTLFQ 128
            |.:|..|...:||:..      .|..::.:.|               ::.::|:  |..::|
Zfish     6 GISSATPTEEMNGAGNLMDFLDEPFPDVGTYE---------------DFHTIDWLREKSKDT--- 52

  Fly   129 DEQRKRLTER-----FSLRKDII----RWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSV 184
             ::.:::|.:     :...|.::    .|::.:.||:::..:|..||:.::.::         .:
Zfish    53 -DRHRKITSKSKESIWEFIKSLLDAWSGWLVMLLIGLLSGTLAGVIDLAVDWMT---------DL 107

  Fly   185 KENVPLS----------------DASDRD----------------------LLIPYLY--W-LLF 208
            ||.|.||                ..:|||                      :|..:||  | |.|
Zfish   108 KEGVCLSAFWYSHEQCCWTSNETTFADRDKCPQWQKWAELVTGYTEGAGVYVLNYFLYVLWALFF 172

  Fly   209 SIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKE 273
            |.:.|    ::|....|...|||||::|:.|:|..|...:...||.:|.:.::.:|..||:.|||
Zfish   173 SFLAV----SLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLAVSSGLSLGKE 233

  Fly   274 GPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSL 338
            ||::|.....        ...|...|.  |..:::.::|:.:....|||||.||||||||:||||
Zfish   234 GPLVHVACCC--------GNLFCSLFS--KYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSL 288

  Fly   339 EEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTG-----LFNLGKFDTPLKFDYFE 398
            ||.:.::....:||:..|::::.|||       ..:|.|   |     ||.: ::.||  :...|
Zfish   289 EEVSYYFPLKTLWRSFFAALVAAFTL-------RSINPF---GNNRLVLFYV-EYHTP--WYMAE 340

  Fly   399 LPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPW-------KIGK--VLEAVVVAMMGVTLAC- 453
            |..|::|||.|||    |.:|..:.|      |.|       ::||  |||  |:|:.|:|...
Zfish   341 LVPFILLGVFGGL----WGTLFIRCN------IAWCRRRKTTRLGKYPVLE--VLAVTGITAVLA 393

  Fly   454 ------------LMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEAT--VRSLFHD 504
                        |:....|||..|.:.      || |:          :..:|..|  |..:...
Zfish   394 FPNPYTRRSTSELISELFNDCGALESS------QL-CD----------YINSPNMTRPVDDIPDR 441

  Fly   505 P--PGSHKI---LTLAL-FTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY- 558
            |  ||.:..   ||||| |.:   :::..|||:.:..|:|||:..|||..||::.:    :.|:
Zfish   442 PAGPGVYSALWQLTLALAFKI---IITIFTFGMKIPSGLFIPSMAVGAIAGRIVGIAVEQMAYHH 503

  Fly   559 ----VF-----PQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALIS 614
                :|     |.|:.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.::
Zfish   504 HDWIIFKNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAVT 567

  Fly   615 AKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRDSANY--I 672
            :|||.|.| .||||:..||:|..|.|..:.. .::.| |.:::    |:|.:.:..:||:..  .
Zfish   568 SKWVADAFGKEGIYEAHIQLNGYPYLDQDEF-THRTL-ATDVMRPRRSEPPLSVLTQDSSTLEEA 630

  Fly   673 YEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDL 737
            ..::...|:||||||    ..|.|| |:.|.:.|..||:.:..:   ..|:..:...|:..|.:.
Zfish   631 EALITHTDYNGFPVV----VSRESE-RLIGFVQRRDLILAIKNA---RQKQDGVVSNSVVYFTED 687

  Fly   738 YPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIA 802
            .|:.|:..:         ..:.|...:|.||..|..|..:..:..|||.||||..|| ....|:.
Zfish   688 APQLPASNT---------QPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLV-TRSGRLL 742

  Fly   803 GIITRRDFI 811
            ||||::|.:
Zfish   743 GIITKKDVL 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	183/625 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	46/166 (28%)
		CBS repeat	657..763	CDD:341367	25/107 (23%)
		CBS repeat	769..812	CDD:341367	17/43 (40%)
clcn4	NP_001070786.1	ClC_3_like	87..593	CDD:239656	176/574 (31%)
		CBS_pair_voltage-gated_CLC_euk_bac	603..753	CDD:341367	47/168 (28%)
		CBS repeat	609..704	CDD:341367	25/111 (23%)
		CBS repeat	710..752	CDD:341367	17/43 (40%)