Protein Alignment ClC-b and clcn7

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_012825963.1
• Gene: clcn7 / 733969
• XenbaseID: XB-GENE-995168
• Length: 800
• Species: Xenopus tropicalis
• Alignment Length: 797
• Identity: 379/797 - (47%)
• Similarity: 514/797 - (64%)
• Gaps: 56/797 - (7%)

  Fly    50 LARRATLSGNNHLLDD--SQPLLMGNNSVPPDIPINGSAGSP----------------NRNINSS 96
            :|::.:.||...|.:|  |.|||.|.:|.... |:.....||                |:.:..:
 Frog     4 VAKKVSWSGREQLEEDGESTPLLNGTSSAGAQ-PLRQQYSSPKLYRIGQLSTVDLTDENQELEET 67

  Fly    97 EPIFHLRSRTAAASTPN--------YESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQ 153
            |     .|.|.....|:        ||||||:..||.||.:|:| |:........::.||:|...
 Frog    68 E-----LSTTFTKEIPHNENLLSLKYESLDYDNSENQLFMEEER-RINHAAFRTVEVTRWVICGM 126

  Fly   154 IGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDR-----DLLIPYLYWLLFSIVPV 213
            |||.|.||||.|||::|:|:..|    |..:|:|:      |:     .|....|.|...:...|
 Frog   127 IGIFTGLIACFIDIMVEKLAGVK----YQVIKDNI------DKFTEKGGLSFSLLLWAALNCAFV 181

  Fly   214 AFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIH 278
            ..|:.:|.:|||:.|||||||:|.:|||||||.:||:|||.||.:|||.||.||||.||||||||
 Frog   182 MVGSLIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLMVKVVGVILSVSGGLAVGKEGPMIH 246

  Fly   279 AGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAAS 343
            :|||||||||||:||:..|||:||:.||.|.||||||..|.|||||||||||:||:||||||.||
 Frog   247 SGAVVAAGISQGRSTSLKKDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGAS 311

  Fly   344 FWNQNLIWRTLVASIISVFTLNIVLSAYHGL-NDFTFTGLFNLGKFDT-PLKFDYFELPIFMILG 406
            ||||.|.||...||:||.||||..||.|:.. .|.:..||.|.|:||| ...:.||||||||.:|
 Frog   312 FWNQLLTWRIFFASMISTFTLNFFLSIYNQKPGDLSNPGLINFGRFDTDENSYQYFELPIFMFMG 376

  Fly   407 VTGGLLGAAWNSLNTKINKFRKRFIPWKIGKVLEAVVVAMMGVTLACLMIYFINDCRPLGNDPTN 471
            ..||:|||.:|:||..:..||.|:|..:..:|:||::||.:..|:|.:.||:..||:||..|.|:
 Frog   377 AVGGMLGALFNALNHCLTTFRIRYIHRRFLQVIEAMLVAAVTATVAFVTIYYSTDCQPLRQDDTD 441

  Fly   472 NPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLG 536
            .|:||||.|.||||:|:.:|.|||.:||.||||||||....||.:||::|:.|:|.|:||.||.|
 Frog   442 YPLQLFCADGEYNAMASAFFTTPEKSVRRLFHDPPGSFNPQTLGVFTILYFFLACWTYGLTVSAG 506

  Fly   537 VFIPTALVGAAWGRLLAMLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVE 601
            ||||:.|:|||||||..:|...|.....:..||||||:||||.|||::|||:||:||::|.|| .
 Frog   507 VFIPSLLLGAAWGRLFGILLTIVPNGVSWADPGKYALMGAAAQLGGIVRMTLSLTVIMVEATG-N 570

  Fly   602 TSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIR 666
            .::.||:::.||:||.|||||.||:||..|::..||.|.||.......|.|||::|.||:.::.|
 Frog   571 VTYGFPIMLVLITAKLVGDYFVEGLYDLHIKLQSVPFLHWEAPVTSHSLTAREVMSTPVVWLRRR 635

  Fly   667 DSANYIYEMLK--KCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPE- 728
            :....|.::|.  ..:|||||||::.. |.....|:||:||||||||:|...::||.:...|.:
 Frog   636 EKVGVIVDILSDTSSNHNGFPVVENTV-DSSRPSRLCGMILRSQLIVLLKHKVFVERENLSLVQR 699

  Fly   729 -TSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHL 792
             ..::.|||.|||||.|:|:....::....:||:.||||:|..|....|:||:|::|||||||||
 Frog   700 RLKLKDFRDAYPRFPPIQSIHVSQDERECQMDLTEFMNPTPYTVPQDASLPRVFKLFRALGLRHL 764

  Fly   793 LVINHENRIAGIITRRD 809
            :|:::.||:.|::||:|
 Frog   765 VVVDNHNRVVGLVTRKD 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	285/530 (54%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	70/162 (43%)
		CBS repeat	657..763	CDD:341367	41/109 (38%)
		CBS repeat	769..812	CDD:341367	21/41 (51%)
clcn7	XP_012825963.1	ClC_6_like	89..614	CDD:239657	288/536 (54%)
		CBS_pair_voltage-gated_CLC_euk_bac	620..785	CDD:341367	70/163 (43%)
		CBS repeat	626..735	CDD:341367	41/109 (38%)
		CBS repeat	741..784	CDD:341367	21/41 (51%)