DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and clcn2c

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001306200.1	Gene:	clcn2c / 563453	ZFINID:	ZDB-GENE-050506-73	Length:	810	Species:	Danio rerio

Alignment Length:	762	Identity:	178/762 - (23%)
Similarity:	329/762 - (43%)	Gaps:	163/762 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 WIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVP 212
            ||..:.:|.|...|:..:||.: :|....:.::|.||         :|..:::.||.|:.:|::.
Zfish    59 WIFLMILGFILGTISFLMDIFV-DLFTDAHRWIYYSV---------ADYHVVVQYLVWVSYSMIL 113

  Fly   213 VAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGG-LAGGKEGPM 276
            :.|.|.....:.|...|||||::|:.|.||.:...:..:||..|.:. :|.|:|. |..|||||.
Zfish   114 MCFAAGFANIVSPQAVGSGIPEMKTALRGVVMQEYLTFRTLVSKVVS-LTCVLGSELPVGKEGPF 177

  Fly   277 IHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEA 341
            :|.|::.|:.:.:     |:..|.  ..::::...::.:..|.|.|:...|.:||||.|||:|..
Zfish   178 VHIGSLCASLLCK-----FMALFS--NIYKNEARNKELLTVGCAVGIGCCFASPIGGALFSIEVT 235

  Fly   342 ASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKFDTPLKFDYFELPIFMILG 406
            |.::.....||..:::........: |..:| ..:.|...|: ..|:.....||..|||:|:.:|
Zfish   236 AMYYLPRNYWRAFLSATFGAIIFRL-LPVWH-REEETLMALY-ATKYRLDFPFDLQELPVFVAMG 297

  Fly   407 VTGGLLGAAWNSLNTKINKF------------RKRFIPWKIGKVLEAVVVAMMG--------VTL 451
            :..||.||.:..|..||..|            |..|....:..||.:.:....|        :|.
Zfish   298 IVCGLGGAFFVFLYGKITLFVKEKKASNSLLMRNCFYYSALTSVLISTLTFPPGFGQFMAGKLTQ 362

  Fly   452 ACLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLAL 516
            ...:|.|.:|     ...:|:.:....:||::   .|.| :.|.|.|            .:.|.:
Zfish   363 RYSLISFFDD-----RTWSNHSIVKDFDDNDH---LAAW-KHPYANV------------FVVLFV 406

  Fly   517 FTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLL--AMLTYY---------VFPQAEFLHPGK 570
            |.::.:.:|..:..|.:..|.|:|..::||.:|||:  .|.|.:         ::|    :.||.
Zfish   407 FVIMKFWMSALSITLPIPCGSFVPIFVIGAGFGRLIGEGMATLFPEGFNTDGHIYP----IVPGA 467

  Fly   571 YALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVN- 634
            ||::||||...||.. |:|.:||:||.|| ..|:..|::|::|.:..|.......||||.|::.
Zfish   468 YAVVGAAALTAGVTH-TMSTAVIMMELTG-HLSYSLPILISVILSNMVSQSLQPSIYDTVIRIKR 530

  Fly   635 --HVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRSE 697
              ::|:|.|......| :...:.:::.|..|.:..:...::::|...:....|:|      :.:|
Zfish   531 LPYLPLLRWGQRENSK-IHVEDFMNRDVRFITLNSTYRDVFKILCSGNLKTVPMV------KSTE 588

  Fly   698 GR-VCGIILRSQLIVILL-KSLYVENKRFWLP-----------ETSIQTFRDLYPRFPSIKSVRK 749
            .. :.|.|.|:||:.:|: ::.|:....:.:|           |.|......:.|..| :||..|
Zfish   589 SMLLLGSIERAQLLALLIERTQYLRGGAYSIPARSKVHFQTATEDSSSASAQVSPSTP-LKSALK 652

  Fly   750 -------------------------------------------------------LDEKINYTVD 759
                                                                   |||::|:.
Zfish   653 RPTADEEQLNNNVYDSGLSFKTFFCSRPDTDAMKNDPDAHDDMILQEIEKWEEQQLDEQVNFN-- 715

  Fly   760 LSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIIT 806
             |..::|:|.::....::.:...:|..|.|.:..|.: ..|:.|:::
Zfish   716 -SCQIDPAPFQLVDRTTLHKTHSMFSVLNLDYAFVTS-VGRLVGVVS 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	32/201 (16%)
		ClC_6_like	115..639	CDD:239657	141/525 (27%)
		Voltage_CLC	213..620	CDD:279048	119/438 (27%)
		CBS	653..811	CDD:223591	34/222 (15%)
clcn2c	NP_001306200.1	ClC_1_like	58..535	CDD:239655	140/523 (27%)
		Voltage_CLC	116..515	CDD:279048	119/436 (27%)
		CBS_pair_EriC_assoc_euk_bac	<719..767	CDD:239964	8/43 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810