Protein Alignment ClC-b and clcn5a

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_001920783.2
• Gene: clcn5a / 562336
• ZFINID: ZDB-GENE-091113-15
• Length: 811
• Species: Danio rerio
• Alignment Length: 824
• Identity: 230/824 - (27%)
• Similarity: 369/824 - (44%)
• Gaps: 182/824 - (22%)

  Fly    84 GSAGSPNRNINSSEPIFHLRSRTAAASTPNYESLDYEVCENTLFQDEQR--------------KR 134
            |..|.|.......||:      ....:..::.::|: |.|.:..:|..|              ||
Zfish    57 GPNGIPKLMDLLDEPV------PGVGTYEDFNTIDW-VREKSKDRDRHREIAIKSKESTWALLKR 114

  Fly   135 LTERFSLRKDIIRWIIFIQIGIITALIACTIDI-------IIEELSIRKYTFLYNSVKENVPLSD 192
            :::.||      .|::.:.:|:::..:|..|||       :.|.:.:..:.|.:.....|...:.
Zfish   115 ISDAFS------GWLLMLLVGLMSGALAGGIDISAHWMTDLKEGVCLNGFWFNHEHCCWNSNETT 173

  Fly   193 ASDRD----------LLI-----PYLY---------W-LLFSIVPVAFGAAMVTYIEPITAGSGI 232
            ..:||          |::     |:.|         | ||||.:.|    ::|....|...||||
Zfish   174 FQERDKCPKWKSWAELIVGTNSGPFAYIMNYLMYVSWALLFSFLAV----SLVRAFAPYACGSGI 234

  Fly   233 PQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLK 297
            |::|:.|:|..|...:...||.:|.|.::.:|..||:.|||||::|.....|..:.
Zfish   235 PEIKTILSGFIIRGYLGKWTLMIKTITLVLAVSSGLSLGKEGPLVHVACCCANILC--------- 290

  Fly   298 DFRIFKAFRDDHEKRDFVLGGGAA-GVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISV 361
              .:|..:|.:..||..||...|| |||.||||||||:||||||.:.::....:||:..|::::.
Zfish   291 --HLFTKYRRNEAKRREVLSAAAAVGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA 353

  Fly   362 FTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKIN 424
            |||       ..:|.|  :...||.: :|.:|  :...||..|::||:.||:.||.:...|....
Zfish   354 FTL-------RSINPFGNSRLVLFYV-EFHSP--WHLLELIPFILLGIFGGIWGAFFIRANIWWC 408

  Fly   425 KFRKRFIPWKIG--KVLEAVVVAMMGVTLAC-----------LMIYFINDCRPLGNDPTNNPVQL 476
            :.||   ..::|  .|||.:||..:...||.           |:....|||..|.:....|
Zfish   409 RRRK---TTRLGHYPVLEVLVVTAVTAVLAFPNSYTRMSTSELISELFNDCGLLDSSQLCN---- 466

  Fly   477 FCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILT----LALFTVVYYVLSCATFGLNVSLGV 537
                  |:.|:.    |..::  ....|.|....:.|    |:|..:...:::..|||:.:..|:
Zfish   467 ------YSNVSV----TKSSS--DALPDRPAGPDVYTAMWQLSLALIFKMLITVVTFGMKLPSGL 519

  Fly   538 FIPTALVGAAWGRLLAM----LTYY-----VF-----PQAEFLHPGKYALIGAAANLGGVLRMTI 588
            |||:..|||..||||.:    |.||     :|     |.|:.:.||.||::||.|.||||.|||:
Zfish   520 FIPSMAVGAIAGRLLGVGMEQLAYYHHDWVIFRGWCSPGADCITPGLYAMVGATACLGGVTRMTV 584

  Fly   589 SLSVILMETTGVETSFFFPLIIALISAKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKA 652
            ||.||:.|.|| ...:..||:.|.:::|||.|.. .||||:..|::|..|.|..:....:|.| |
Zfish   585 SLVVIMFELTG-GLEYIVPLMAATMTSKWVADALGREGIYEAHIRLNGYPFLESKEEFSHKTL-A 647

  Fly   653 REIL----SKPVICIKIRDSANY--IYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIV 711
            .:::    |.|.:.:..:|..|.  :..::.:..::|||||..     ....|:.|.:.|..|::
Zfish   648 MDVMRPRRSDPPLSVITQDGMNVEEVESLIAETSYSGFPVVVS-----HESQRLVGFVQRRDLVI 707

  Fly   712 ILLKSLYVENKRFWLPETSIQTFRDLYPRF---------PSIKSVRKLDEKINYTVDLSMFMNPS 767
                  .::|.| ...|..:...|..:..:         |.:|              |...|:.|
Zfish   708 ------SIDNAR-QRQEGVVSASRIFFTEYTPPQPPNSPPPLK--------------LRGIMDLS 751

  Fly   768 PIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            |..|..|.::..:..|||.||||..|| .|..|:.||||::|.:
Zfish   752 PFTVTDHTAMDIVVDIFRKLGLRQCLV-THNGRLLGIITKKDIL 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	180/604 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	42/175 (24%)
		CBS repeat	657..763	CDD:341367	20/116 (17%)
		CBS repeat	769..812	CDD:341367	18/43 (42%)
clcn5a	XP_001920783.2	ClC_3_like	129..635	CDD:239656	170/550 (31%)
		CBS_pair_voltage-gated_CLC_euk_bac	646..796	CDD:341367	43/177 (24%)
		CBS repeat	652..747	CDD:341367	20/120 (17%)
		CBS repeat	753..795	CDD:341367	18/43 (42%)